ML414(NGI-1)
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- $68 - $1700
- Product name: ML414(NGI-1)
- CAS: 790702-57-7
- MF: C17H22N4O3S2
- MW: 394.51
- EINECS:-0
- MDL Number:MFCD06358908
- Synonyms:Benzamide, 5-[(dimethylamino)sulfonyl]-N-(5-methyl-2-thiazolyl)-2-(1-pyrrolidinyl)-;NGI-1 >=95% (HPLC);
5-(dimethylsulfamoyl)-N-(5-methyl-1,3-thiazol-2-yl)-2-(pyrrolidin-1-yl)benz amide;ML414(NGI-1);ML414;NGI-1;NGI-1; NGI1; NGI 1; ML414; ML 414; ML-414、;NGI-1 (ML414)
17 prices
Selected condition：
Brand
- AK Scientific
- American Custom Chemicals Corporation
- Biorbyt Ltd
- Biosynth Carbosynth
- Crysdot
- DC Chemicals
- Sigma-Aldrich
- Tocris
- TRC
Package
- 5
- 5MG
- 25
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 1g
- ManufacturerAK Scientific
- Product number0238CH
- Product description5-(Dimethylsulfamoyl)-N-(5-methyl-1,3-thiazol-2-yl)-2-pyrrolidin-1-ylbenzamide
- Packaging10mg
- Price$178
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0009737
- Product descriptionNGI1 95.00%
- Packaging5MG
- Price$451.85
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb546210
- Product descriptionNGI-1 >98%
- Packaging10mg
- Price$190.4
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb546210
- Product descriptionNGI-1 >98%
- Packaging50mg
- Price$513.4
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberBN164083
- Product descriptionNGI1 NEW
- Packaging10mg
- Price$95
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31004980
- Product descriptionML414 99%
- Packaging100mg
- Price$480
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31004980
- Product descriptionML414 99%
- Packaging50mg
- Price$284
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31004980
- Product descriptionML414 99%
- Packaging25mg
- Price$222
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31004980
- Product descriptionML414 99%
- Packaging10mg
- Price$93
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31004980
- Product descriptionML414 99%
- Packaging5mg
- Price$68
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC11281
- Product descriptionNGI-1(ML414) >98%
- Packaging250mg
- Price$850
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC11281
- Product descriptionNGI-1(ML414) >98%
- Packaging1g
- Price$1700
- Updated2021-12-16
- Buy
- ManufacturerSigma-Aldrich
- Product numberSML1620
- Product descriptionNGI-1 ≥95% (HPLC)
- Packaging25mg
- Price$261
- Updated2024-03-01
- Buy
- ManufacturerSigma-Aldrich
- Product numberSML1620
- Product descriptionNGI-1 ≥95% (HPLC)
- Packaging5mg
- Price$108
- Updated2024-03-01
- Buy
- ManufacturerTocris
- Product number6652
- Product descriptionNGI1 ≥98%(HPLC)
- Packaging5
- Price$78
- Updated2021-12-16
- Buy
- ManufacturerTocris
- Product number6652
- Product descriptionNGI1 ≥98%(HPLC)
- Packaging25
- Price$181
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 0238CH | 5-(Dimethylsulfamoyl)-N-(5-methyl-1,3-thiazol-2-yl)-2-pyrrolidin-1-ylbenzamide | 10mg | $178 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0009737 | NGI1 95.00% | 5MG | $451.85 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb546210 | NGI-1 >98% | 10mg | $190.4 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb546210 | NGI-1 >98% | 50mg | $513.4 | 2021-12-16 | Buy |
| Biosynth Carbosynth | BN164083 | NGI1 NEW | 10mg | $95 | 2021-12-16 | Buy |
| Crysdot | CD31004980 | ML414 99% | 100mg | $480 | 2021-12-16 | Buy |
| Crysdot | CD31004980 | ML414 99% | 50mg | $284 | 2021-12-16 | Buy |
| Crysdot | CD31004980 | ML414 99% | 25mg | $222 | 2021-12-16 | Buy |
| Crysdot | CD31004980 | ML414 99% | 10mg | $93 | 2021-12-16 | Buy |
| Crysdot | CD31004980 | ML414 99% | 5mg | $68 | 2021-12-16 | Buy |
| DC Chemicals | DC11281 | NGI-1(ML414) >98% | 250mg | $850 | 2021-12-16 | Buy |
| DC Chemicals | DC11281 | NGI-1(ML414) >98% | 1g | $1700 | 2021-12-16 | Buy |
| Sigma-Aldrich | SML1620 | NGI-1 ≥95% (HPLC) | 25mg | $261 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML1620 | NGI-1 ≥95% (HPLC) | 5mg | $108 | 2024-03-01 | Buy |
| Tocris | 6652 | NGI1 ≥98%(HPLC) | 5 | $78 | 2021-12-16 | Buy |
| Tocris | 6652 | NGI1 ≥98%(HPLC) | 25 | $181 | 2021-12-16 | Buy |
Properties
Density :1.372±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :Soluble in DMSO (up to 5 mg/ml)
pka :7.48±0.50(Predicted)
form :powder
color :white to beige
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
storage temp. :2-8°C
solubility :Soluble in DMSO (up to 5 mg/ml)
pka :7.48±0.50(Predicted)
form :powder
color :white to beige
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Safety Information
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Description
NGI-1 (790702-57-7) is a cell-permeable inhibitor of oligosaccharyltransferase (OST) – IC50 = 1.1 μM.1 It blocks cell-surface localization and signaling of the epidermal growth factor receptor (EGFR) glycoprotein and selectively arrests proliferation only in cells dependent on EGFR for survival. NGI-1 caused G1 arrest and senescence in RTK-dependent NSCLC cells (PC9, HCC827, H3255,H1581). NGI-1 displays antiviral behavior against various flaviviruses (Dengue, West Nile, Yellow fever and Zika).2 It also was able to overcome resistance to EGFR tyrosine kinase inhibitors in mutant NSCLC cells3 and enhance radiosensitivity and cytotoxic effects of chemotherapy in glioma cells with high levels of RTK activation4.Related product price
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