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ChemicalBook >> CAS DataBase List >> ML414(NGI-1)

ML414(NGI-1)

ML414(NGI-1) price.
  • $68 - $1700
  • Product name: ML414(NGI-1)
  • CAS: 790702-57-7
  • MF: C17H22N4O3S2
  • MW: 394.51
  • EINECS:-0
  • MDL Number:MFCD06358908
  • Synonyms:Benzamide, 5-[(dimethylamino)sulfonyl]-N-(5-methyl-2-thiazolyl)-2-(1-pyrrolidinyl)-;NGI-1 >=95% (HPLC);
    5-(dimethylsulfamoyl)-N-(5-methyl-1,3-thiazol-2-yl)-2-(pyrrolidin-1-yl)benz amide;ML414(NGI-1);ML414;NGI-1;NGI-1; NGI1; NGI 1; ML414; ML 414; ML-414、;NGI-1 (ML414)
Price17 Properties Safety Information Description
17 prices
Selected condition：
Brand
  • AK Scientific
  • American Custom Chemicals Corporation
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • Crysdot
  • DC Chemicals
  • Sigma-Aldrich
  • Tocris
  • TRC
Package
  • 5
  • 5MG
  • 10mg
  • 25mg
  • 25
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • ManufacturerAK Scientific
  • Product number0238CH
  • Product description5-(Dimethylsulfamoyl)-N-(5-methyl-1,3-thiazol-2-yl)-2-pyrrolidin-1-ylbenzamide
  • Packaging10mg
  • Price$178
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0009737
  • Product descriptionNGI1 95.00%
  • Packaging5MG
  • Price$451.85
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb546210
  • Product descriptionNGI-1 >98%
  • Packaging10mg
  • Price$190.4
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb546210
  • Product descriptionNGI-1 >98%
  • Packaging50mg
  • Price$513.4
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberBN164083
  • Product descriptionNGI1 NEW
  • Packaging10mg
  • Price$95
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31004980
  • Product descriptionML414 99%
  • Packaging5mg
  • Price$68
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31004980
  • Product descriptionML414 99%
  • Packaging10mg
  • Price$93
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31004980
  • Product descriptionML414 99%
  • Packaging25mg
  • Price$222
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31004980
  • Product descriptionML414 99%
  • Packaging50mg
  • Price$284
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31004980
  • Product descriptionML414 99%
  • Packaging100mg
  • Price$480
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC11281
  • Product descriptionNGI-1(ML414) >98%
  • Packaging250mg
  • Price$850
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC11281
  • Product descriptionNGI-1(ML414) >98%
  • Packaging1g
  • Price$1700
  • Updated2021-12-16
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberSML1620
  • Product descriptionNGI-1 ≥95% (HPLC)
  • Packaging5mg
  • Price$108
  • Updated2024-03-01
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberSML1620
  • Product descriptionNGI-1 ≥95% (HPLC)
  • Packaging25mg
  • Price$261
  • Updated2024-03-01
  • Buy
  • ManufacturerTocris
  • Product number6652
  • Product descriptionNGI1 ≥98%(HPLC)
  • Packaging5
  • Price$78
  • Updated2021-12-16
  • Buy
  • ManufacturerTocris
  • Product number6652
  • Product descriptionNGI1 ≥98%(HPLC)
  • Packaging25
  • Price$181
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 0238CH 5-(Dimethylsulfamoyl)-N-(5-methyl-1,3-thiazol-2-yl)-2-pyrrolidin-1-ylbenzamide 10mg $178 2021-12-16 Buy
American Custom Chemicals Corporation INB0009737 NGI1 95.00% 5MG $451.85 2021-12-16 Buy
Biorbyt Ltd orb546210 NGI-1 >98% 10mg $190.4 2021-12-16 Buy
Biorbyt Ltd orb546210 NGI-1 >98% 50mg $513.4 2021-12-16 Buy
Biosynth Carbosynth BN164083 NGI1 NEW 10mg $95 2021-12-16 Buy
Crysdot CD31004980 ML414 99% 5mg $68 2021-12-16 Buy
Crysdot CD31004980 ML414 99% 10mg $93 2021-12-16 Buy
Crysdot CD31004980 ML414 99% 25mg $222 2021-12-16 Buy
Crysdot CD31004980 ML414 99% 50mg $284 2021-12-16 Buy
Crysdot CD31004980 ML414 99% 100mg $480 2021-12-16 Buy
DC Chemicals DC11281 NGI-1(ML414) >98% 250mg $850 2021-12-16 Buy
DC Chemicals DC11281 NGI-1(ML414) >98% 1g $1700 2021-12-16 Buy
Sigma-Aldrich SML1620 NGI-1 ≥95% (HPLC) 5mg $108 2024-03-01 Buy
Sigma-Aldrich SML1620 NGI-1 ≥95% (HPLC) 25mg $261 2024-03-01 Buy
Tocris 6652 NGI1 ≥98%(HPLC) 5 $78 2021-12-16 Buy
Tocris 6652 NGI1 ≥98%(HPLC) 25 $181 2021-12-16 Buy
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Properties

Density :1.372±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :Soluble in DMSO (up to 5 mg/ml)
pka :7.48±0.50(Predicted)
form :powder
color :white to beige
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

NGI-1 (790702-57-7) is a cell-permeable inhibitor of oligosaccharyltransferase (OST) – IC50 = 1.1 μM.1 It blocks cell-surface localization and signaling of the epidermal growth factor receptor (EGFR) glycoprotein and selectively arrests proliferation only in cells dependent on EGFR for survival. NGI-1 caused G1 arrest and senescence in RTK-dependent NSCLC cells (PC9, HCC827, H3255,H1581). NGI-1 displays antiviral behavior against various flaviviruses (Dengue, West Nile, Yellow fever and Zika).2 It also was able to overcome resistance to EGFR tyrosine kinase inhibitors in mutant NSCLC cells3 and enhance radiosensitivity and cytotoxic effects of chemotherapy in glioma cells with high levels of RTK activation4.

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