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tert-Butyl carbazate

tert-Butyl carbazate Structure
tert-Butyl carbazate structure
CAS No.
870-46-2
Chemical Name:
tert-Butyl carbazate
Synonyms
tert-butyl hydrazinecarboxylate;carbazate;BOC-NHNH2;BOC-HYDRAZINE;T-BUTYLCARBAZATE;tert-Butyl N-aminocarbamate;HYDRAZINECARBOXYLIC ACID TERT-BUTYL ESTER;BOC-HYDRAZIDE;TERT-BUTOXYCARBONYL HYDRAZIDE;T-BOC-HYDRAZIDE
CBNumber:
CB9686391
Molecular Formula:
C5H12N2O2
Molecular Weight:
132.16
MDL Number:
MFCD00007593
MOL File:
870-46-2.mol
MSDS File:
SDS
Last updated:2024-11-01 18:09:03
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tert-Butyl carbazate Properties

Melting point 39-42 °C (lit.)
Boiling point 63-65 °C/0.1 mmHg (lit.)
Density 1.02
refractive index 1.4496 (estimate)
Flash point 197 °F
storage temp. Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility Soluble in ethanol and methanol.
pka 10.74±0.20(Predicted)
form Crystalline Lumps
color White to slightly yellow
Sensitive Moisture Sensitive
BRN 1756967
InChIKey DKACXUFSLUYRFU-UHFFFAOYSA-N
CAS DataBase Reference 870-46-2(CAS DataBase Reference)
EPA Substance Registry System Hydrazinecarboxylic acid, 1,1-dimethylethyl ester (870-46-2)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS02
Signal word  Danger
Hazard statements  H228
Precautionary statements  P210
Hazard Codes  T-F,T,F
Risk Statements  48-36/37/38-24/25-11
Safety Statements  45-36/37/39-16-24/25
RIDADR  1325
WGK Germany  3
F  21
TSCA  Yes
HazardClass  4.1
PackingGroup  III
HS Code  29280090
NFPA 704
2
3 0

tert-Butyl carbazate price More Price(54)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich B91005 tert-Butyl carbazate 98% 870-46-2 5g $38.5 2024-03-01 Buy
Sigma-Aldrich B91005 tert-Butyl carbazate 98% 870-46-2 25g $79.4 2024-03-01 Buy
Alfa Aesar A12383 tert-Butyl carbazate, 98+% 870-46-2 25g $74.2 2024-03-01 Buy
Alfa Aesar A12383 tert-Butyl carbazate, 98+% 870-46-2 100g $126.65 2024-03-01 Buy
Sigma-Aldrich B91005 tert-Butyl carbazate 98% 870-46-2 100g $148 2024-03-01 Buy
Product number Packaging Price Buy
B91005 5g $38.5 Buy
B91005 25g $79.4 Buy
A12383 25g $74.2 Buy
A12383 100g $126.65 Buy
B91005 100g $148 Buy

tert-Butyl carbazate Chemical Properties,Uses,Production

Chemical Properties

White to pale yellow lumps

Uses

Starting material for preparing BOC-azide, a reagent to introduce the BOC amino protection.

Uses

tert-Butyl carbazate is used in a palladium-catalyzed cross-coupling with vinyl halides to prepare N-Boc-N-alkenylhydrazines. It is utilized in solid phase peptide synthesis and in the optical purity determination of alfa-amino aldehyde. It reacts with aldehydes to get hydrazones, which finds application as an intermediate in the synthesis of HIV-1 protease inhibitors. In addition to this, it is used as a starting material for the preparation of BOC-azide, sulfonic and carboxylic hydrazides.

Synthesis Reference(s)

Journal of the American Chemical Society, 82, p. 2725, 1960 DOI: 10.1021/ja01496a018
Chemical and Pharmaceutical Bulletin, 18, p. 217, 1970 DOI: 10.1248/cpb.18.217

Purification Methods

Distil it in a Claisen flask with a water or oil bath at ca 80o. After a couple of drops have distilled, the carbazate is collected as an oil which solidifies to a snow white solid. It can be crystallised with 90% recovery from a 1:1 mixture of pet ether (b 30-60o) and pet ether (b 60-70o). [Carpino et al. Org Synth Coll Vol V 166 1973, Caprino et al. Org Synth 44 20 1964, Beilstein 3 IV 175.]

tert-Butyl carbazate synthesis

24424-99-5
870-46-2
Synthesis of tert-Butyl carbazate from Di-tert-butyl dicarbonate

tert-Butyl carbazate Preparation Products And Raw materials

Raw materials

Hydrazinium hydroxide solution Di-tert-butyl dicarbonate Hydrazine hydrate Isopropyl alcohol N-Boc-L-Histidine
N,N'-Di-tert-butoxycarbonyl-L-histidine

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Preparation Products

PYRIDIN-2-YLMETHYL-HYDRAZINE PYRIDIN-3-YLMETHYL-HYDRAZINE (2-METHOXY-1-METHYL-ETHYL)-HYDRAZINE PYRIDIN-4-YLMETHYL-HYDRAZINE CYCLOBUTYLHYDRAZINE
3,5-DIMETHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID DI-TERT-BUTYL HYDRAZODICARBOXYLATE tert-butyl azidoformate 1-N-Boc-2-Methylhydrazine tert-butyl 2-cyano-1H-pyrrol-1-ylcarbaMate
1-Boc-2-isopropylhydrazine Des-N-(methoxycarbonyl)-L-tert-leucine Bis-Boc Atazanavir TERT-BUTYL N-(TERT-BUTOXYCARBONYLOXY)CARBAMATE tert-Butyl 2-methylcarbazate TERT-BUTYL 2-CYCLOHEXYLHYDRAZINECARBOXYLATE

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tert-Butyl carbazate Suppliers

Global( 628)Suppliers
Supplier Tel Email Country ProdList Advantage
GenChem & GenPharm (Changzhou) Co., Ltd. 		+86-86020003 +86-18861157602 sales03@genchem.cn China 104 58
Changzhou Ditong Chemical Co.,Ltd
+86-0519-88299272 info@edengenechem.com China 2158 58
Hebei Mojin Biotechnology Co., Ltd 		+86 13288715578 +8613288715578 sales@hbmojin.com China 12839 58
Hebei Chuanghai Biotechnology Co,.LTD 		+86-13131129325 sales1@chuanghaibio.com China 5892 58
Hebei Weibang Biotechnology Co., Ltd 		+8617732866630 bess@weibangbio.com China 18153 58
Anhui Ruihan Technology Co., Ltd 		+8617756083858 daisy@anhuiruihan.com China 973 58
Hebei Weimiao Import and Export Trade Co., Ltd. 		+86-19948166995 +86-19948166995 sale01@hbweimiao.com China 76 58
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 20287 58
Sigma Audley 		+86-15937194204 +86-18126314766 nova@sh-teruiop.com China 467 58
hebei hongtan Biotechnology Co., Ltd 		+86-86-1913198-3935 +8617331935328 sales03@chemcn.cn China 970 58
Supplier Advantage
GenChem & GenPharm (Changzhou) Co., Ltd. 		58
Changzhou Ditong Chemical Co.,Ltd
58
Hebei Mojin Biotechnology Co., Ltd 		58
Hebei Chuanghai Biotechnology Co,.LTD 		58
Hebei Weibang Biotechnology Co., Ltd 		58
Anhui Ruihan Technology Co., Ltd 		58
Hebei Weimiao Import and Export Trade Co., Ltd. 		58
Henan Fengda Chemical Co., Ltd 		58
Sigma Audley 		58
hebei hongtan Biotechnology Co., Ltd 		58

View Lastest Price from tert-Butyl carbazate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
tert-Butyl carbazate pictures 2024-11-25 tert-Butyl carbazate
870-46-2
 US $6.00 / KG 1KG 99% 20TONS Hebei Longbang Technology Co., Ltd
Tert-Butyl carbazate pictures 2024-11-22 Tert-Butyl carbazate
870-46-2
 US $30.00 / kg 1kg 99% 2000kg hebei hongtan Biotechnology Co., Ltd
tert-Butyl carbazate pictures 2024-11-01 tert-Butyl carbazate
870-46-2
 US $0.00-0.00 / KG 1KG 99% 500000kg Hebei Weibang Biotechnology Co., Ltd

tert-Butyl carbazate Spectrum

tert-Butyl carbazate(870-46-2)MStert-Butyl carbazate(870-46-2)1HNMRtert-Butyl carbazate(870-46-2)13CNMRtert-Butyl carbazate(870-46-2)IR1tert-Butyl carbazate(870-46-2)IR2tert-Butyl carbazate(870-46-2)Raman

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TERT-BUTOXYCARBONYLHYDRAZINE TERT-BOC-HYDRAZIDE TERT-BUTYLOXYCARBAZATE T-BUTOXYCARBONYL HYDRAZIDE T-BUTYLOXYCARBONYL-HYDRAZIDE tert-Butyl hydrazinocarboxylate tert-Butylcarbazate,98+% BOC-HYDRAZIDE 98% TERT-BUTYL CARBAZATE 99% tert-Butyl carbazate, 97+% tert-Butoxycarbonyl hydrazide, Boc-hydrazide N-T-BUTOXYCARBONYL-HYDRAZIDE CustoM-Made product tert-Butyl carbaza 1-Boc hydrazine tert-Butyl carbazate Hydrazinecarboxylic acid-1,1-dimethyl ester BOC-Hydrazine tert-Butyl carbazate Tert-Cutyl Carbazate tert-Butyl hydrazinoformate Boc-hydrazide≥ 99% (GC) Carbazic acid 1,1-dimethylethyl ester N-Aminocarbamic acid tert-butyl ester tert-Butyl carbazate,99% LABOTEST-BB LT00053500 Boc-hydrazine tert-Butoxycarbonylhydrazine Carbazic Acid tert-Butyl Ester TERT-BUTYL CARBAZATE FOR SYNTHESIS hydrazinecarboxylicacid,1,1-dimethylethylester AKOS B028820 Tert-Butyl carbazateCAS BOC-hydrazide（Tert-Butyl carbazate） tert-Butyl carbazate,tert-Butoxycarbonyl hydrazide, Boc-hydrazide tert-Butyl carbazate tert-Butyl carbazate, 99% 100GR tert-Butyl carbazate, 99% 500GR +-BUTYL CARBAZATE CARBONIC ACID TERT-BUTYL ESTER HYDRAZIDE CARBAZINIC ACID TERT-BUTYL ESTER CARBAZIC ACID TERT-BUTYL ESTER Baloxavir Impurity 35 ert-Butyl carbazate tert-Butyl carbazate T-BOC-HYDRAZIDE tert-Butyl carbazate solution tert-Butyl Carbazate > tert-Butyl carbazate, 99%, for synthesis 1-Boc hydrazine(BOC-NHNH2) tert-Butyl Carbazate (TBC) tert-Butyl Carbazate extrapure, 98% TERT-BUTOXYCARBONYL HYDRAZIDE tert-butyloxycarbonyl-hydrazide T-BOC-HYDRAZIDE T-BUTYLCARBAZATE tert-Butyl N-aminocarbamate tert-butyl hydrazinecarboxylate BOC-HYDRAZIDE BOC-HYDRAZINE BOC-NHNH2 carbazate