1,6-BIS(CYCLOHEXYLOXIMINOCARBONYLAMINO)HEXANE
- CAS No.
- 83654-05-1
- Chemical Name:
- 1,6-BIS(CYCLOHEXYLOXIMINOCARBONYLAMINO)HEXANE
- Synonyms
- U-57908;Rg 80267;RHC-80267;RXSVYGIGWRDVQC-UHFFFAOYSA-N;RHC-80267 - CAS 83654-05-1 - Calbiochem;1,6-bis(cyclohexyloximinocarbonyl)hexane;1,6-BIS(CYCLOHEXYLOXIMINOCARBONYLAMINO)HEXANE;1,6-Di(o-(carbamoyl)cyclohexanone oxime)hexane;1,6-bis(Cyclohexyloximinocarbonylamino)hexane, U 57908;O,O'-[1,6-Hexanediylbis(iminocarbonyl)]dioximecyclohexanone
- CBNumber:
- CB9686432
- Molecular Formula:
- C20H34N4O4
- Molecular Weight:
- 394.52
- MDL Number:
- MFCD00210844
- MOL File:
- 83654-05-1.mol
| Melting point | 118-121℃ |
|---|---|
| Density | 1.21±0.1 g/cm3(Predicted) |
| RTECS | GW1485000 |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO: 9 mg/mL |
| form | solid |
| pka | 13.81±0.46(Predicted) |
| color | white |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months |
| EWG's Food Scores | 1 |
| FDA UNII | 9VB68H5WIT |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Safety Statements | 22-24/25 |
| WGK Germany | 3 |
1,6-BIS(CYCLOHEXYLOXIMINOCARBONYLAMINO)HEXANE price More Price(32)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | R2028 | RHC 80267 ≥98% (HPLC), solid | 83654-05-1 | 5mg | $117 | 2024-03-01 | Buy |
| Sigma-Aldrich | 554994 | RHC-80267 | 83654-05-1 | 10mg | $159 | 2024-03-01 | Buy |
| Alfa Aesar | J67323 | RHC-80267, 98% | 83654-05-1 | 10mg | $138 | 2023-06-20 | Buy |
| Cayman Chemical | 16432 | RHC-80267 ≥95% | 83654-05-1 | 5mg | $33 | 2024-03-01 | Buy |
| Cayman Chemical | 16432 | RHC-80267 ≥95% | 83654-05-1 | 10mg | $53 | 2024-03-01 | Buy |
1,6-BIS(CYCLOHEXYLOXIMINOCARBONYLAMINO)HEXANE Chemical Properties,Uses,Production
Description
RHC-80267 (83654-05-1) inhibits DAG Lipase activity in a variety of cell types and tissues, including canine platelets, bovine adrenal chromaffin cells, human adrenal glomerulosa cells, rat thyroid lobes and pancreatic minilobules. IC50 in canine platelets is 4 μM.1
Uses
RHC-80267 is a selective inhibitor of DAG lipase, which plays an important role in the production of arachidonic acid.
Definition
ChEBI: N-[6-[[(cyclohexylideneamino)oxy-oxomethyl]amino]hexyl]carbamic acid (cyclohexylideneamino) ester is a carbamate ester and an organonitrogen compound.
General Description
Selective inhibitor of DAG lipase activity in canine platelets (IC50 = 4 nM) and in a variety of mammalian cells. Also inhibits glucose- and carbachol-induced insulin release from intact islets. An inhibitor of Angiotensin II (Cat. No. 05-23-0101) and ATP-induced synthesis of 6-keto-prostaglandin F1α.
Biological Activity
Inhibitor of diacylglycerol lipase (IC 50 values are 1.1 and 4 μ M in rat cardiac myocytes and canine platelets respectively). Weakly inhibits phospholipases C and A 2 . Potentiates acetylcholine evoked relaxation in mesenteric arteries by the inhibition of cholinesterase activity (IC 50 = 4 μ M).
Biochem/physiol Actions
Product does not compete with ATP.
storage
Store at +4°C
References
1) Southerland and Amin (1982), Anthranilic acid amides: a novel class of antiangiogenic VEGF receptor kinase inhibitors; J. Biol. Chem., 257 14006 2) Rindlisbacher et al. (1990), Advances in the structural biology, design and clinical development of VEGF-R kinase inhibitors for the treatment of angiogenesis; J. Neurochem., 54 1247 3) Chandra Sekar et al. (1987), Anthranilic acid amides: a novel class of antiangiogenic VEGF receptor kinase inhibitors; Arch. Biochem. Biophys., 256 509 4) Levasseur et al. (1984), Advances in the structural biology, design and clinical development of VEGF-R kinase inhibitors for the treatment of angiogenesis; Prostaglandins, 27 673 5) Natarajan et al. (1988), Anthranilic acid amides: a novel class of antiangiogenic VEGF receptor kinase inhibitors; Biochem. Biophys. Res. Commun., 156 717
1,6-BIS(CYCLOHEXYLOXIMINOCARBONYLAMINO)HEXANE Preparation Products And Raw materials
Raw materials
Preparation Products
1,6-BIS(CYCLOHEXYLOXIMINOCARBONYLAMINO)HEXANE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32165 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 22883 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49734 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38632 | 58 | |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57505 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15839 | 69 |
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4428 | 55 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8447 | 60 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9806 | 58 |
View Lastest Price from 1,6-BIS(CYCLOHEXYLOXIMINOCARBONYLAMINO)HEXANE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-19 | RHC 80267
83654-05-1
|
US $31.00-108.00 / mg | 99.54% | 10g | TargetMol Chemicals Inc. | ||
 |
2022-08-20 | 1,6-BIS(CYCLOHEXYLOXIMINOCARBONYLAMINO)HEXANE
83654-05-1
|
US $1.10 / g | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited |
-
- RHC 80267
83654-05-1
- US $31.00-108.00 / mg
- 99.54%
- TargetMol Chemicals Inc.
-
- 1,6-BIS(CYCLOHEXYLOXIMINOCARBONYLAMINO)HEXANE
83654-05-1
- US $1.10 / g
- 99.00%
- Dideu Industries Group Limited