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RO-31-8220

RO-31-8220 Structure
RO-31-8220 structure
CAS No.
138489-18-6
Chemical Name:
RO-31-8220
Synonyms
CS-1132;RO-31-8220;Ro31-8220MsOH;Ro 31-8220 Mesylat;Ro 31-8220/Ro318220;RO-31-8220 USP/EP/BP;BisindolylMaleiMide IX Mesylate;BISINDOLYLMALEIMIDE IX, METHANESULFONATE;Ro-31-8220 - CAS 138489-18-6 - Calbiochem;Bisindolylmaleimide IX (Ro 31-8220 Mesylate)
CBNumber:
CB9711637
Molecular Formula:
C25H23N5O2S
Molecular Weight:
457.55
MDL Number:
MFCD03788207
MOL File:
138489-18-6.mol
MSDS File:
SDS
Last updated:2024-11-19 20:33:22
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RO-31-8220 Properties

storage temp. 2-8°C
solubility DMSO:52.77(Max Conc. mg/mL);95.31(Max Conc. mM)
DMF:25.0(Max Conc. mg/mL);45.15(Max Conc. mM)
DMF:PBS (pH 7.2) (1:9):0.1(Max Conc. mg/mL);0.18(Max Conc. mM)
Ethanol:2.77(Max Conc. mg/mL);5.0(Max Conc. mM)
form Red solid
color Red
FDA UNII 3JPC9J3C82

SAFETY

Risk and Safety Statements

HS Code  2933790090

RO-31-8220 price More Price(35)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 557520 Ro-31-8220 - CAS 138489-18-6 - Calbiochem A cell-permeable, reversible, competitive, and selective inhibitor of protein kinase C (PKC; IC?? = 10 nM) over CaM kinase II (IC?? = 17 μM) and protein kinase A (IC?? = 900 nM). 138489-18-6 500μg $159 2024-03-01 Buy
Sigma-Aldrich R136 Ro 31-8220 methanesulfonate salt solid 138489-18-6 1MG $201 2023-06-20 Buy
Sigma-Aldrich R136 Ro 31-8220 methanesulfonate salt solid 138489-18-6 5MG $631 2023-06-20 Buy
Cayman Chemical 13334 Bisindolylmaleimide IX (mesylate) ≥98% 138489-18-6 1mg $44 2024-03-01 Buy
Cayman Chemical 13334 Bisindolylmaleimide IX (mesylate) ≥98% 138489-18-6 5mg $166 2024-03-01 Buy
Product number Packaging Price Buy
557520 500μg $159 Buy
R136 1MG $201 Buy
R136 5MG $631 Buy
13334 1mg $44 Buy
13334 5mg $166 Buy

RO-31-8220 Chemical Properties,Uses,Production

Description

Ro 31-8220 mesylate is a potent PKC inhibitor, inhibits PKCα, PKCβI, PKCβII, PKCγ, PKCε and rat brain PKC with IC50 values of 5, 24, 14, 27, 24 and 23 nM, also inhibits MAPKAP -K1b, MSK1, S6K1 and GSK3β with IC50 of 3, 8, 15, 38 nM.

Uses

Ro 31-8220 Mesylate is a protein kinase C (PKC) inhibitor.

General Description

Ro 31-8220 is a bisindolylmaleimide derivative of staurosporine. Ro 31-8220 blocks MAP kinase phosphatase-1 (MKP-1) expression, induces c-Jun expression and stimulates Jun N-terminal Kinase (JNK1). It has immunosuppressive properties.

Biochem/physiol Actions

Inhibitor of GRK-5 (G protein-coupled receptor kinase); PKC (protein kinase C); MAPKAP kinase 1β and p70 S6 kinase.

storage

+4°C

RO-31-8220 Preparation Products And Raw materials

Raw materials

Preparation Products

RO-31-8220 Suppliers

Global( 135)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32957 60
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29811 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32165 58
Hubei Ipure Biology Co., Ltd 		+8613367258412 ada@ipurechemical.com China 10319 58
HONG KONG IPURE BIOLOGY CO.,LIMITED 		86 18062405514 18062405514 ada@ipurechemical.com CHINA 3461 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6312 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 22883 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10473 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38632 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
TargetMol Chemicals Inc. 		58
Hubei Ipure Biology Co., Ltd 		58
HONG KONG IPURE BIOLOGY CO.,LIMITED 		58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		58
Dideu Industries Group Limited 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
InvivoChem 		58
TargetMol Chemicals Inc. 		58

View Lastest Price from RO-31-8220 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Ro 31-8220 Mesylate pictures 2024-11-19 Ro 31-8220 Mesylate
138489-18-6
 US $44.00-162.00 / mg 99.18% 10g TargetMol Chemicals Inc.
Bisindolylmaleimide IX mesylate pictures 2020-01-02 Bisindolylmaleimide IX mesylate
138489-18-6
 US $1.00 / KG 1KG Min98% HPLC g/kg/ton Career Henan Chemical Co

RO-31-8220 Spectrum

RO-31-8220(138489-18-6)1HNMR

138489-18-6(RO-31-8220)Related Search:

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BISINDOLYLMALEIMIDE VII 2,2',3,3',4,4'-hexahydroxy-1,1'-biphenyl-6,6'-dimethanol dimethyl ether 3,4-Di-1H-indol-3-yl-1H-pyrrole-2,5-dione RO-31-8220 1-METHYLINDOLE-3-ACETAMIDE
RO-31-8220,RO 31-8220 METHANESULFONATE,RO 31-8220 MESYLATE 3-Isopropenyl-1-methyl-1H-pyrrole RO 31-8220 (BISINDOYLMALEIMIDINE IX)

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RO-31-8220 BISINDOLYLMALEIMIDE IX, METHANESULFONATE 3-[1-[3-(AMIDINOTHIO)PROPYL-1H-INDOL-3-YL]-3-(1-METHYL-1H-INDOL-3-YL)MALEIMIDE BISINDOLYLMALEIMIDE IX METHANESULPHONATE SALT BisindolylMaleiMide IX Mesylate BisindolylMaleiMide IX . Methansulfonate [Ro 31-8220] Carbamimidothioic acid, 3-[3-[2,5-dihydro-4-(1-methyl-1H-indol-3-yl)-2,5-dioxo-1H-pyrrol-3-yl]-1H-indol-1-yl]propyl ester, methanesulfonate (1:1) Ro31-8220MsOH Ro 31-8220 Mesylat Ro 31-8220/Ro318220 Ro-31-8220 - CAS 138489-18-6 - Calbiochem 3-[3-[2,5-Dihydro-4-(1-methyl-1H-indol-3-yl)-2,5-dioxo-1H-pyrrol-3-yl]-1H-indol-1-yl]propyl carbamimidothioic acid ester mesylate RO 31-8220 METHANESULFONATE; BISINDOLYLMALEIMIDE IX MESYLATE;RO318220 CS-1132 Bisindolylmaleimide IX (Ro 31-8220 Mesylate) RO-31-8220 USP/EP/BP 3-(3-(4-(1-methyl-1H-indol-3-yl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl)-1H-indol-1-yl)propyl carbamimidothioate 138489-18-6 C25H23N5O2SCH4O3S C25H23N5O2S C26H27N5O5S2 Smad TGF-beta Inhibitors TGF-beta/Smad inhibitor