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Exendin-3 (9-39) amide

Exendin-3 (9-39) amide Structure
CAS No.
133514-43-9
Chemical Name:
Exendin-3 (9-39) amide
Synonyms
EXENDIN (9-39);EXENDIN 3 (9-39);Exendin-4 (9-39);Hexanal Impurity 5;EXENDIN (9-39) AMIDE;EXENDIN FRAGMENT 9-39;EXENDIN-3 (9-39) AMIDE;EXENDIN [9-39] PEPTIDE;Exendin (9-39) Acetate;Exendin 4 (9-39) amide
CBNumber:
CB0109941
Molecular Formula:
C149H234N40O47S
Molecular Weight:
3369.76
MOL File:
133514-43-9.mol
Modify Date:
2024/7/2 8:54:55

Exendin-3 (9-39) amide Properties

Density 1.51
RTECS LF2460000
storage temp. Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility H2O : 50 mg/mL (14.84 mM; Need ultrasonic)
form Solid
color Off-white to pale purple
Water Solubility Soluble in water at 1mg/ml
InChIKey WSEVKKHALHSUMB-UHFFFAOYSA-N

SAFETY

Risk and Safety Statements

WGK Germany  3

Exendin-3 (9-39) amide price More Price(1)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) E7269 Exendin Fragment 9-39 ≥95% (HPLC) 133514-43-9 0.1MG ₹37367.9 2022-06-14 Buy
Product number Packaging Price Buy
E7269 0.1MG ₹37367.9 Buy

Exendin-3 (9-39) amide Chemical Properties,Uses,Production

Description

Exendin-3 (9-39) amide is a truncated form of the exendin-4 peptide that acts as a potent competitive antagonist for the glucagon-like peptide 1 receptor (GLP-1R; Kd = 1.7 nM in CHL cells transfected with cloned human GLP-1). It inhibits exendin-3-induced increases in cAMP levels in guinea pig pancreas cells (IC50 = 20 nM). Exendin-3 (9-39) amide administration in the hypothalamus (10 and 100 μg, i.c.v.) reverses GLP-1 inhibition of feeding behavior in rats.

Uses

Biological probe.

General Description

Exendin Fragment 9-39 is an antagonist of glucagon-like peptide-1 (GLP-1) receptor, and also acts as an inhibitor of glucosedependent insulinotropic polypeptide (GIP)-receptor binding. It also prevents the production of cAMP by GIP. GLP-1, along with GIP, acts as a physiological incretin.

Exendin-3 (9-39) amide Preparation Products And Raw materials

Raw materials

Preparation Products

Exendin-3 (9-39) amide Suppliers

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ASP-LEU-SER-LYS-GLN-MET-GLU-GLU-GLU-ALA-VAL-ARG-LEU-PHE-ILE-GLU-TRP-LEU-LYS-ASN-GLY-GLY-PRO-SER-SER-GLY-ALA-PRO-PRO-PRO-SER-NH2 H-ASP-LEU-SER-LYS-GLN-MET-GLU-GLU-GLU-ALA-VAL-ARG-LEU-PHE-ILE-GLU-TRP-LEU-LYS-ASN-GLY-GLY-PRO-SER-SER-GLY-ALA-PRO-PRO-PRO-SER-NH2 EXENDIN 3 (9-39) EXENDIN-3 (9-39) AMIDE EXENDIN (9-39) EXENDIN (9-39) AMIDE EXENDIN [9-39] PEPTIDE EXENDIN FRAGMENT 9-39 DLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2 M.W. 3369.79 C149H234N40O47S ASP-LEU-SER-LYS-GLN-MET-GLU-GLU-GLU-ALA-VAL-ARG-LEU-PHE-ILE-GLU-TRP-LEU-LYS-ASN-GLY-GLY-PRO-SER-SER-GLY-ALA-PRO-PRO-PRO-SER-NH2: DLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2 Exendin 3 (heloderma horridum), 1-de-L-histidine-2-de-L-serine-3-de-L-aspartic acid-4-deglycine-5-de-L-threonine-6-de-L-phenylalanine-7-de-L-threonine-8-de-L-serine- 9-39-Exendin 3(Heloderma horridum) EXENDIN FRAGMENT 9-39;EXENDIN (9-39) H-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2 Exendin FragMent 9-39Exendin H-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2 acetate salt 9-39-Exendin 3(Heloderma horridum) (9CI) Exendin (9-39) Acetate Exendin 4 (9-39) amide Asp-LEU-SER-LYS-GLN-MET-GLU-GLU-GLU-ALA-VAL-ARG-LEU-PHE-ILE-GLU-TRp-LEU-LYS-ASN-GLY-GLY-PRO-SER-SER-GLY-ALA-PRO-PRO-PRO-SER-NH2, ≥95%(HPLC) L-Serinamide, L-α-aspartyl-L-leucyl-L-seryl-L-lysyl-L-glutaminyl-L-methionyl-L-α-glutamyl-L-α-glutamyl-L-α-glutamyl-L-alanyl-L-valyl-L-arginyl-L-leucyl-L-phenylalanyl-L-isoleucyl-L-α-glutamyl-L-tryptophyl-L-leucyl-L-lysyl-L-asparaginylglycylglycyl-L-prolyl-L-seryl-L-serylglycyl-L-alanyl-L-prolyl-L-p... Exendin Fragment 9-39 >=95% (HPLC) Exendin-3 (9-39) amide USP/EP/BP GCGR,Glucagon Receptor,Avexitide,Inhibitor,inhibit Exendin-3 (9-39) amide/Avexitide Hexanal Impurity 5 Asp-LEU-SER-LYS-GLN-MET-GLU-GLU-GLU-ALA-VAL-ARG-LEU-PHE-ILE-GLU-TR|p|-LEU-LYS-ASN-GLY-GLY-PRO-SER-SER-GLY-ALA-PRO-PRO-PRO-SER-NH2 Exendin-4 (9-39) 133514-43-9 C149H234N40O47S C149H234N40O47S1 Hormones Obesity Research Exendin Cytokines, Growth Factors and Hormones BioChemical Cell Biology Cell Signaling and Neuroscience Peptide GLP-1 Receptor LigandsObesity Research Cytokines Growth Factors and Hormones (Obesity) ExendinPeptides for Cell Biology Hormones Obesity Peptides Obesity Research Other Obesity Research Products Glucagon receptor and related