Incadronic
- CAS No.
- 124351-85-5
- Chemical Name:
- Incadronic
- Synonyms
- Incadronic;((Cycloheptylamino)methylene)diphosphonic acid;((cycloheptylamino)methylene)bis(phosphonic acid);[(cycloheptylamino)-phosphonomethyl]phosphonic acid;Phosphonic acid, P,P'-[(cycloheptylamino)methylene]bis-
- CBNumber:
- CB01178940
- Molecular Formula:
- C8H19NO6P2
- Molecular Weight:
- 287.19
- MOL File:
- 124351-85-5.mol
- Modify Date:
- 2023/7/12 16:57:31
Incadronic Chemical Properties,Uses,Production
Description
Bisphonal, a new third generation drug, was launched in Japan for the treatment of osteoporosis. It can be prepared in two steps by heating cycloheptylamine, triethylorthoformate and diethyl phosphite followed by ester hydrolysis. The mechanism of action is not well understood. Bisphonal has no effect on bone mineralization but tightly binds to calcified bone matrix and inhibits bone resorption. It causes a decrease in the number and activity of osteoclasts (morphology and decrease in H+ secretion). They seem to undergo cell death with an impairment in the process of osteoclast formation. Bisphonal does not induce osteomalacia and its activity is partly mediated through osteoblasts (releases an inhibitor of osteoclast recruitment). It is a potent inhibitor of squalene synthase (50-fold) maybe by Mg2+ chelation or as a pyrophosphate mimic, undergoes practically no metabolism, and stimulates renal production of 1,25-dihydroxyvitamin D.
Uses
Incandronate is a bisphosphonate derivative. Bisphosphonates are most widely used as agents for treating osteoporosis and have also been used for other purposes such as herbicides, anticancer agents, and antiparasitics.
Incadronic Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 13028896684 | China | 56057 | 58 | Inquiry |
| Energy Chemical | 021-58432009 400-005-6266 | China | 44843 | 58 | Inquiry |
| Beijing Comparison Pharmaceutical Technology Co., Ltd | 15801002657 15701683040 | China | 4749 | 58 | Inquiry |
| Aikon International Limited | 025-58851090 13611564524 | China | 15952 | 58 | Inquiry |
| Wuhan Yingnuo Pharmaceutical Technology Co., Ltd. | +86-027-59232304 15387063101 | China | 9903 | 58 | Inquiry |
| ChemStrong Scientific Co.,Ltd | 0755-0755-66853366 13670046396 | China | 18018 | 56 | Inquiry |
| Nantong Hanfang Biotechnology Co. , Ltd. | 18616537568 | China | 30968 | 58 | Inquiry |
| TargetMol Chemicals Inc. | 15002134094 | China | 28118 | 58 | Inquiry |
| Olix (Shanghai) Pharmaceutical Technology Co., Ltd | 17316404525 | China | 9627 | 58 | Inquiry |