Forskolin
- CAS No.
- 66575-29-9
- Chemical Name:
- Forskolin
- Synonyms
- HL 362;CS-736;Forsklin;COLEONOL;Boforsin;ForsLean;FORSKOLIN;COLFORSIN;NSC 35708;Forskolii
- CBNumber:
- CB0167677
- Molecular Formula:
- C22H34O7
- Molecular Weight:
- 410.5
- MOL File:
- 66575-29-9.mol
- Modify Date:
- 2024/8/7 19:09:42
| Melting point | 282-232 °C |
|---|---|
| Boiling point | 520℃ |
| alpha | D25 -26.19° (c = 1.68 in CHCl3) |
| Density | 1.23 |
| refractive index | 1.5300 (estimate) |
| Flash point | 172℃ |
| storage temp. | room temp |
| solubility | DMSO: 5 mg/mL stable at least 6 months at room temperature |
| form | powder |
| pka | 11.00±0.70(Predicted) |
| color | off-white |
| Water Solubility | Soluble in ethanol, dimethylsulfoxide and chloroform. Insolule in water. |
| λmax | 305nm(lit.) |
| Merck | 14,2476 |
| BRN | 1692716 |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 4 months. |
| InChIKey | OHCQJHSOBUTRHG-KGGHGJDLSA-N |
| LogP | 2.406 (est) |
| CAS DataBase Reference | 66575-29-9 |
Forskolin price More Price(14)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | F6886 | Forskolin from Coleus forskohlii, ≥98% (HPLC), powder | 66575-29-9 | 10MG | ₹30494.03 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | F6886 | Forskolin from Coleus forskohlii, ≥98% (HPLC), powder | 66575-29-9 | 25MG | ₹57231.78 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | F6886 | Forskolin from Coleus forskohlii, ≥98% (HPLC), powder | 66575-29-9 | 50MG | ₹97793.05 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | F3917 | Forskolin For use in molecular biology applications | 66575-29-9 | 10MG | ₹30634.75 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | F3917 | Forskolin For use in molecular biology applications | 66575-29-9 | 25MG | ₹59028.73 | 2022-06-14 | Buy |
Forskolin Chemical Properties,Uses,Production
Chemical Properties
Colorless Crystalline Solid
Uses
Forskolin is a diterpene isolated from Coleus forskohlii, possessing vasodilating and cardiostimulatory properties. Forskolin resensitizes cell receptors by activating the enzyme adenylyl cyclase and increasing the intracellular levels of cAMP.
General Description
Forskolin, present predominantly in the root of Coleus forskohlii plant, is a potential pharmacological compound. It is used for treating hypertension, respiratory disorders and obesity. Forskolin is a diterpenoid capable of modulating adenylate cyclase enzyme and cyclic adenosine monophosphate (cAMP) levels. Engineering forskolin biosynthetic pathway caters its commercial production for pharmacological use. Forskolin has antioxidant and anti-inflammatory property and reduces hyperglycemia by stimulating insulin release. Forskolin promotes differentiation of hepatoma HepaRG cells and activates farnesoid X receptor (FXR) and pregnane X receptor(PXR).
Biological Activity
Cell-permeable activator of adenylyl cyclase. Hypotensive and vasodilatory agent. Induces neuronal differentiation in stem cells and in several neuroblastoma. Also available as part of the PKA Tocriset™ .
Purification Methods
It is an antihypertensive, a positive ionotropic, a platelet aggregation inhibitor, and it has adenylate cyclase activating properties [Chem Abstr 89 244150 1978, de Souza et al. Med Res Rev 3 201 1983, X-ray: Tandon et al. Indian J Chem 15B 880 1977]. [Beilstein 18/5 V 55.]
Forskolin Preparation Products And Raw materials
Global( 434)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Venbiotech | +91-9344202656 +91-9940417693 | Tamil Nadu, India | 14 | 58 | Inquiry |
| Deccan Nutraceuticals Pvt. Ltd | +91-9822641298 +91-9822641298 | Mumbai, India | 18 | 58 | Inquiry |
| Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
| Ambe Phytoextracts Private Limited | +91-1143764376 +91-1143764376 | New Delhi, India | 37 | 58 | Inquiry |
| Apollo ingredients Pvt Ltd | +91-7219888886 | Maharashtra, India | 31 | 58 | Inquiry |
| The Gwalior Forest Products Ltd | +91-9301541750 +91-9425429994 | Madhya Pradesh, India | 11 | 58 | Inquiry |
| Sris Pharmaceuticals | 91-9989522441 | Telangana, India | 130 | 58 | Inquiry |
| Otto Chemie Pvt. Ltd. | +91 9820041841 | Mumbai, India | 5873 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Health First Trading | 08048361342Ext 159 | Delhi, India | 3 | 58 | Inquiry |
Related articles
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10a-beta,10b-alpha))-10-alph
1-b)pyran-1-one,dodecahydro-5-(acetyloxy)-3-ethenyl-3,4a,7,7,10a-1h-naphtho(
pentamethyl-6,10,10b-trihydroxy-,(3r-(3-alpha,4a-beta,5-beta,6-beta,6a-alpha,
FORSKOLIN FROM COLEUS FORSKOHLII
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FORSKOLIN 98+%
FORSKOLIN, 99+%
Forsklin
1H-Naphtho[2,1-b]pyran-1-one, 5-(acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-, (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-
Forskolin ForsLean Colforsin HL 362 NSC 357088 NSC 375489
BETA-ACETOXY-8,13-EPOXY-1ALPHA,6BETA,9ALPHA-TRIHYDROXY-LABD-14-EN-11-ONE
FORSKOHLIN
FORSKOLIN
FORSKOLIN, COLEUS FORSKOHLII
COLEONOL
COLFORSIN
(3R,4AR,5S,6S,6aS,10S,10aR,10bS)-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-3-vinyldod
Boforsin
(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-(Acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1H-Naphtho[2,1-b]pyran-1-one
ForsLean
HL 362
L 75-1362B
NSC 35708
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NSC 375489
Forskolin (40 mg) (7Beta-acetoxy-8,13-epoxy-1alpha,6Beta,9alpha-trihydroxy-labd-14-en-11-one)
Forskolii
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Forskolin, 98%, from Coleus forskohlii
Forskolin (plant extract)
Forskolin ( Coleus Forskohlii extract)
Forskolin - Coleonol
CS-736
Forskolin, Coleus forskohlii - CAS 66575-29-9 - Calbiochem
Forskolin >
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