N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE
![N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE Structure](CAS/GIF/136132-67-7.gif)
- CAS No.
- 136132-67-7
- Chemical Name:
- N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE
- Synonyms
- CPSB;CTSB;z-rr-amc;APP secretase;Z-RR-AMC, 2HCL;Z-ARG-ARG-MCA.HCL;Z-ARG-ARG-AMC 2HCL;Z-Arg-Arg-AMC/Z-RR-AMC;Cathepsin B Active human;Z-ARG-ARG-MCA HYDROCHLORIDE
- CBNumber:
- CB0188887
- Molecular Formula:
- C30H40ClN9O6
- Molecular Weight:
- 658.15
- MOL File:
- 136132-67-7.mol
- Modify Date:
- 2024/7/2 8:54:57
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() ![]() GHS07,GHS08 |
---|---|
Signal word | Danger |
Hazard statements | H315-H319-H360D |
Precautionary statements | P201-P302+P352-P305+P351+P338-P308+P313 |
Hazard Codes | Xi |
Risk Statements | 36/37/38 |
Safety Statements | 26-36 |
WGK Germany | 3 |
N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE price More Price(3)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich(India) | C5429 | Z-Arg-Arg-7-amido-4-methylcoumarin hydrochloride | 136132-67-7 | 5MG | ₹8486.8 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | SRP0289 | Cathepsin B Active human recombinant, expressed in FreeStyle? 293-F cells, ≥90% (SDS-PAGE) | 136132-67-7 | 10μG | ₹60250.8 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | C5429 | Z-Arg-Arg-7-amido-4-methylcoumarin hydrochloride | 136132-67-7 | 25MG | ₹28025.93 | 2022-06-14 | Buy |
N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE Chemical Properties,Uses,Production
Uses
Z-Arg-Arg-7-amido-4-methylcoumarin hydrochloride has been used:
- as a cathepsin B substrate in zymography analysis of protease in feces extract.
- in cathepsin B activity assay.
- as a fluorogenic peptide substrate to determine the matrix metalloproteinase enzyme activity.
General Description
Human cathepsin B (GenBank Accession No. NM_001908), CD33 signal peptide(amino acids 1-16) + Cathepsin B (amino acids 18-339), with C-terminal HIS tag, MW = 43 kDa, expressed in FreeStyle 293-F cells. Cathepsin B is a cysteine protease, found in the lysosome of normal cells and tissues. Cathepsin B active human is encoded by the gene CTSB, located on human chromosome 8p23.1.
Biochem/physiol Actions
Cathepsin B Active human primarily is a preproenzyme, glycosylated on rough endoplasmic reticulum. Processing of procathepsin B to a 31 kDa, single chain active form occurs in the lysosome. It is further processed to double chain form with a 25/26 kDa heavy chain and 5 kDa heavy chain in lysosome. Cathepsin B, functions as an exopeptidase at low pH. At higher pH in endosomes or neutral pH, cathepsin B functions as endopeptidase. Cathepsin B expression is upregulated in malignant tumors and facilitates tumor invasion. Cathepsin B might reduce the production of amyloid-β peptide associated with Alzheimerβs disease. It also plays a key role in neuroprotective functions.
N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE Suppliers
Supplier | Tel | Country | ProdList | Advantage | Inquiry |
---|---|---|---|---|---|
career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29825 | 58 | Inquiry |
Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | China | 8744 | 58 | Inquiry |
Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | China | 10522 | 58 | Inquiry |
Zhengzhou Anbu Chem Co.,Ltd | +86-0371-88006763; +8615988602810 | China | 3000 | 58 | Inquiry |
Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | China | 33350 | 58 | Inquiry |
DONBOO AMINO ACID COMPANY | +8613063595538 | China | 9365 | 58 | Inquiry |
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66113011 18112977050 | China | 10529 | 58 | Inquiry |
Wuxi Helen Biotechnology Co., Ltd., | 0510-85629785 18013409632 | China | 14081 | 58 | Inquiry |
Shanghai Macklin Biochemical Co.,Ltd. | 15221275939 15221275939 | China | 16168 | 55 | Inquiry |
Hangzhou Beiputai Biopharmaceutical Co., Ltd | 0571-85350119 13305819357 | China | 3850 | 58 | Inquiry |
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