ChemicalBook > Product Catalog >Biochemical Engineering >Amino Acids and Derivatives >Arginine derivatives >N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE

N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE

CAS No.: 136132-67-7

Chemical Name:: N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE

Synonyms: CPSB;CTSB;z-rr-amc;APP secretase;Z-RR-AMC, 2HCL;Z-ARG-ARG-MCA.HCL;Z-ARG-ARG-AMC 2HCL;Z-Arg-Arg-AMC/Z-RR-AMC;Cathepsin B Active human;Z-ARG-ARG-MCA HYDROCHLORIDE

CBNumber:: CB0188887

Molecular Formula:: C30H40ClN9O6

Molecular Weight:: 658.15

MOL File:: 136132-67-7.mol

Modify Date:: 2025/1/27 9:38:02

Request For Quotation

N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE Properties

storage temp.	-20°C
solubility	DMSO: 5mg/mL water: soluble
form	aqueous solution
color	White to off-white
biological source	human
Water Solubility	water: soluble
Specific Activity	≥2228pmol/min-μg

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07,GHS08
Signal word	Danger
Hazard statements	H315-H319-H360D
Precautionary statements	P201-P302+P352-P305+P351+P338-P308+P313
Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36
WGK Germany	3

N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE price More Price(3)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	C5429	Z-Arg-Arg-7-amido-4-methylcoumarin hydrochloride	136132-67-7	5MG	₹8486.8	2022-06-14	Buy
Sigma-Aldrich(India)	SRP0289	Cathepsin B Active human recombinant, expressed in FreeStyle? 293-F cells, ≥90% (SDS-PAGE)	136132-67-7	10μG	₹60250.8	2022-06-14	Buy
Sigma-Aldrich(India)	C5429	Z-Arg-Arg-7-amido-4-methylcoumarin hydrochloride	136132-67-7	25MG	₹28025.93	2022-06-14	Buy

Product number	Packaging	Price	Buy
C5429	5MG	₹8486.8	Buy
SRP0289	10μG	₹60250.8	Buy
C5429	25MG	₹28025.93	Buy

N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE Chemical Properties,Uses,Production

Uses

Z-Arg-Arg-7-amido-4-methylcoumarin hydrochloride has been used:

as a cathepsin B substrate in zymography analysis of protease in feces extract.
in cathepsin B activity assay.
as a fluorogenic peptide substrate to determine the matrix metalloproteinase enzyme activity.

General Description

Human cathepsin B (GenBank Accession No. NM_001908), CD33 signal peptide(amino acids 1-16) + Cathepsin B (amino acids 18-339), with C-terminal HIS tag, MW = 43 kDa, expressed in FreeStyle 293-F cells. Cathepsin B is a cysteine protease, found in the lysosome of normal cells and tissues. Cathepsin B active human is encoded by the gene CTSB, located on human chromosome 8p23.1.

Biochem/physiol Actions

Cathepsin B Active human primarily is a preproenzyme, glycosylated on rough endoplasmic reticulum. Processing of procathepsin B to a 31 kDa, single chain active form occurs in the lysosome. It is further processed to double chain form with a 25/26 kDa heavy chain and 5 kDa heavy chain in lysosome. Cathepsin B, functions as an exopeptidase at low pH. At higher pH in endosomes or neutral pH, cathepsin B functions as endopeptidase. Cathepsin B expression is upregulated in malignant tumors and facilitates tumor invasion. Cathepsin B might reduce the production of amyloid-β peptide associated with Alzheimerβs disease. It also plays a key role in neuroprotective functions.

N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE Suppliers

Global( 79)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29808	58	Inquiry
Shaanxi Dideu Medichem Co. Ltd	+86-029-89586680 +86-18192503167	China	7859	58	Inquiry
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	China	10473	58	Inquiry
Zhengzhou Anbu Chem Co.,Ltd	+86-0371-88006763; +8615988602810	China	2998	58	Inquiry
Shanghai Acmec Biochemical Technology Co., Ltd.	+86-18621343501; +undefined18621343501	China	33338	58	Inquiry
SHANGHAI KEAN TECHNOLOGY CO., LTD.	+8613817748580	China	40066	58	Inquiry
DONBOO AMINO ACID COMPANY	+8618051385538	China	9363	58	Inquiry
Wuxi Helen Biotechnology Co., Ltd.,	0510-85629785 18013409632	China	14081	58	Inquiry
Hangzhou Beiputai Biopharmaceutical Co., Ltd	0571-85350119 15888826472	China	3851	58	Inquiry
Hubei Chenghai Chemical Co., Ltd	18327245847 18327245847	China	9918	58	Inquiry

Supplier	Advantage
career henan chemical co	58
Shaanxi Dideu Medichem Co. Ltd	58
Zhejiang J&C Biological Technology Co.,Limited	58
Zhengzhou Anbu Chem Co.,Ltd	58
Shanghai Acmec Biochemical Technology Co., Ltd.	58
SHANGHAI KEAN TECHNOLOGY CO., LTD.	58
DONBOO AMINO ACID COMPANY	58
Wuxi Helen Biotechnology Co., Ltd.,	58
Hangzhou Beiputai Biopharmaceutical Co., Ltd	58
Hubei Chenghai Chemical Co., Ltd	58

136132-67-7(N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE)Related Search:

Z-Arg-AMC CATHEPSIN B SUBSTRATE I, COLORIMETRIC N-ALPHA-CBZ-ARG-ARG-PRO-PHE-HIS-STA-ILE-HIS-N-EPSILON-BOC-LYS METHYL ESTER NA-CBZ-ARG-ARG 4-METHOXY-B-NAPHTHYLAMIDE Z-ARG-AMC HCL

Perindopril L-Arginine N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE Z-ARG-ARG-7-AMINO-4-TRIFLUOROMETHYLCOUMARIN BENZYL N-(2-AMINOETHYL)CARBAMATE HYDROCHLORIDE L(+)-Arginine

N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE H-ORN-AMC 2 HCL L-ARGININE 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE H-GLY-GLY-AMC HCL H-ARG-ALA-NH2 2 HCL

L-ARGININE 7-AMIDO-4-METHYLCOUMARIN DIHYDROCHLORIDE 2-(METHYLAMINO)-N-(4-METHYLPHENYL)ACETAMIDE HYDROCHLORIDE H-ALA-ARG-AMC HCL

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N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE Z-ARG-ARG-7-AMIDO-4-METHYL COUMARIN, DIHCL Z-ARG-ARG-AMC 2HCL Z-ARG-ARG-AMC HYDROCHLORIDE SALT Z-ARG-ARG-MCA HYDROCHLORIDE Z-ARG-ARG-MCA(HYDROCHLORIDE FORM) Z-L-ARGINYL-L-ARGININE-7-AMIDO-4-METHYLCOUMARIN 2HCL Z-RR-AMC, 2HCL z-arg-arg-7-amido-4-methylcoumarin hydrochloride z-rr-amc Z-ARG-ARG-MCA.HCL ANTI-CATB (CENTER) antibody produced in rabbit APP secretase CPSB CTSB Cathepsin B Active human BENZYLOXYCARBONYL-L-ARGINYL-L-ARGININE 4-METHYLCOUMARYL-7-AMIDE HYDROCHLORIDE CATHEPSIN B SUBSTRATE III, FLUOROGENIC CATHEPSIN B SUBSTRATE IV, FLUOROGENIC na-cbz-arg-arg 7-amido-4-methylcoumarin hydrochlo NA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORI N-CBZ-ILE-GLU-THR-ASP-7-AMINO-4- TRIFLUO ROMETHYLCOU Z-Arg-Arg-7-amido-4-methylcoumarin hydrochloride,Z-RR-AMC Z-Arg-Arg-AMC/Z-RR-AMC N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE USP/EP/BP Recombinant Mouse Cathepsin B/Ctsb Protein, His Tag Recombinant Human Cathepsin B/CTSB Protein, His Tag Z-Arg-Arg-7-amido-4-methylcoumarin CBZ-Arg-Arg-7-amido-4-methylcoumarin hydrochloride Z-Arg-Arg-AMC hydrochloride Mouse Anti-Caspase 8 antibody 136132-67-7 C30H39N9O6 C30H41Cl2N9O6 C30H39N9O6HCl Cathepsins and Granzymes Cathepsin B Caspases Caspase 8 Cell Signaling and Neuroscience Cell Biology Apoptosis and Cell Cycle BioChemical Substrates Substrates