ChemicalBook > Product Catalog >Biochemical Engineering >Amino Acids and Derivatives >Arginine derivatives >N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE

N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE

CAS No.: 136132-67-7

Chemical Name:: N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE

Synonyms: CPSB;CTSB;z-rr-amc;APP secretase;Z-RR-AMC, 2HCL;Z-ARG-ARG-MCA.HCL;Z-ARG-ARG-AMC 2HCL;Z-Arg-Arg-AMC/Z-RR-AMC;Cathepsin B Active human;Z-ARG-ARG-MCA HYDROCHLORIDE

CBNumber:: CB0188887

Molecular Formula:: C30H40ClN9O6

Molecular Weight:: 658.15

MOL File:: 136132-67-7.mol

Modify Date:: 2024/7/2 8:54:57

Request For Quotation

N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE Properties

storage temp.	-20°C
form	aqueous solution
color	White to off-white

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07,GHS08
Signal word	Danger
Hazard statements	H315-H319-H360D
Precautionary statements	P201-P302+P352-P305+P351+P338-P308+P313
Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36
WGK Germany	3

N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE price More Price(3)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	C5429	Z-Arg-Arg-7-amido-4-methylcoumarin hydrochloride	136132-67-7	5MG	₹8486.8	2022-06-14	Buy
Sigma-Aldrich(India)	SRP0289	Cathepsin B Active human recombinant, expressed in FreeStyle? 293-F cells, ≥90% (SDS-PAGE)	136132-67-7	10μG	₹60250.8	2022-06-14	Buy
Sigma-Aldrich(India)	C5429	Z-Arg-Arg-7-amido-4-methylcoumarin hydrochloride	136132-67-7	25MG	₹28025.93	2022-06-14	Buy

Product number	Packaging	Price	Buy
C5429	5MG	₹8486.8	Buy
SRP0289	10μG	₹60250.8	Buy
C5429	25MG	₹28025.93	Buy

N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE Chemical Properties,Uses,Production

Uses

Z-Arg-Arg-7-amido-4-methylcoumarin hydrochloride has been used:

as a cathepsin B substrate in zymography analysis of protease in feces extract.
in cathepsin B activity assay.
as a fluorogenic peptide substrate to determine the matrix metalloproteinase enzyme activity.

General Description

Human cathepsin B (GenBank Accession No. NM_001908), CD33 signal peptide(amino acids 1-16) + Cathepsin B (amino acids 18-339), with C-terminal HIS tag, MW = 43 kDa, expressed in FreeStyle 293-F cells. Cathepsin B is a cysteine protease, found in the lysosome of normal cells and tissues. Cathepsin B active human is encoded by the gene CTSB, located on human chromosome 8p23.1.

Biochem/physiol Actions

Cathepsin B Active human primarily is a preproenzyme, glycosylated on rough endoplasmic reticulum. Processing of procathepsin B to a 31 kDa, single chain active form occurs in the lysosome. It is further processed to double chain form with a 25/26 kDa heavy chain and 5 kDa heavy chain in lysosome. Cathepsin B, functions as an exopeptidase at low pH. At higher pH in endosomes or neutral pH, cathepsin B functions as endopeptidase. Cathepsin B expression is upregulated in malignant tumors and facilitates tumor invasion. Cathepsin B might reduce the production of amyloid-β peptide associated with Alzheimerβs disease. It also plays a key role in neuroprotective functions.

N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE Suppliers

Global( 63)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29825	58	Inquiry
Shaanxi Dideu Medichem Co. Ltd	+86-029-89586680 +86-18192503167	China	8744	58	Inquiry
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	China	10522	58	Inquiry
Zhengzhou Anbu Chem Co.,Ltd	+86-0371-88006763; +8615988602810	China	3000	58	Inquiry
Shanghai Acmec Biochemical Technology Co., Ltd.	+undefined18621343501	China	33350	58	Inquiry
DONBOO AMINO ACID COMPANY	+8613063595538	China	9365	58	Inquiry
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.	025-66113011 18112977050	China	10529	58	Inquiry
Wuxi Helen Biotechnology Co., Ltd.,	0510-85629785 18013409632	China	14081	58	Inquiry
Shanghai Macklin Biochemical Co.,Ltd.	15221275939 15221275939	China	16168	55	Inquiry
Hangzhou Beiputai Biopharmaceutical Co., Ltd	0571-85350119 13305819357	China	3850	58	Inquiry

Supplier	Advantage
career henan chemical co	58
Shaanxi Dideu Medichem Co. Ltd	58
Zhejiang J&C Biological Technology Co.,Limited	58
Zhengzhou Anbu Chem Co.,Ltd	58
Shanghai Acmec Biochemical Technology Co., Ltd.	58
DONBOO AMINO ACID COMPANY	58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.	58
Wuxi Helen Biotechnology Co., Ltd.,	58
Shanghai Macklin Biochemical Co.,Ltd.	55
Hangzhou Beiputai Biopharmaceutical Co., Ltd	58

136132-67-7(N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE)Related Search:

Z-Arg-AMC CATHEPSIN B SUBSTRATE I, COLORIMETRIC N-ALPHA-CBZ-ARG-ARG-PRO-PHE-HIS-STA-ILE-HIS-N-EPSILON-BOC-LYS METHYL ESTER NA-CBZ-ARG-ARG 4-METHOXY-B-NAPHTHYLAMIDE Z-ARG-AMC HCL

Perindopril L-Arginine N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE Z-ARG-ARG-7-AMINO-4-TRIFLUOROMETHYLCOUMARIN BENZYL N-(2-AMINOETHYL)CARBAMATE HYDROCHLORIDE L(+)-Arginine

N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE H-ORN-AMC 2 HCL L-ARGININE 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE H-GLY-GLY-AMC HCL H-ARG-ALA-NH2 2 HCL

L-ARGININE 7-AMIDO-4-METHYLCOUMARIN DIHYDROCHLORIDE 2-(METHYLAMINO)-N-(4-METHYLPHENYL)ACETAMIDE HYDROCHLORIDE H-ALA-ARG-AMC HCL

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N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE Z-ARG-ARG-7-AMIDO-4-METHYL COUMARIN, DIHCL Z-ARG-ARG-AMC 2HCL Z-ARG-ARG-AMC HYDROCHLORIDE SALT Z-ARG-ARG-MCA HYDROCHLORIDE Z-ARG-ARG-MCA(HYDROCHLORIDE FORM) Z-L-ARGINYL-L-ARGININE-7-AMIDO-4-METHYLCOUMARIN 2HCL Z-RR-AMC, 2HCL z-arg-arg-7-amido-4-methylcoumarin hydrochloride z-rr-amc Z-ARG-ARG-MCA.HCL ANTI-CATB (CENTER) antibody produced in rabbit APP secretase CPSB CTSB Cathepsin B Active human BENZYLOXYCARBONYL-L-ARGINYL-L-ARGININE 4-METHYLCOUMARYL-7-AMIDE HYDROCHLORIDE CATHEPSIN B SUBSTRATE III, FLUOROGENIC CATHEPSIN B SUBSTRATE IV, FLUOROGENIC na-cbz-arg-arg 7-amido-4-methylcoumarin hydrochlo NA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORI N-CBZ-ILE-GLU-THR-ASP-7-AMINO-4- TRIFLUO ROMETHYLCOU Z-Arg-Arg-7-amido-4-methylcoumarin hydrochloride,Z-RR-AMC Z-Arg-Arg-AMC/Z-RR-AMC N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE USP/EP/BP Recombinant Mouse Cathepsin B/Ctsb Protein, His Tag Recombinant Human Cathepsin B/CTSB Protein, His Tag Z-Arg-Arg-7-amido-4-methylcoumarin CBZ-Arg-Arg-7-amido-4-methylcoumarin hydrochloride Mouse Anti-Caspase 8 antibody Z-Arg-Arg-AMC hydrochloride 136132-67-7 C30H39N9O6 C30H41Cl2N9O6 C30H39N9O6HCl Cathepsins and Granzymes Cathepsin B Caspases Caspase 8 Cell Signaling and Neuroscience Cell Biology Apoptosis and Cell Cycle BioChemical Substrates Substrates