Indole-4-carboxaldehyde
- CAS No.
- 1074-86-8
- Chemical Name:
- Indole-4-carboxaldehyde
- Synonyms
- 4-INDOLECARBALDEHYDE;1H-INDOLE-4-CARBALDEHYDE;4-FLUOROINDOLE;1H-INDOLE-4-CARBOXALDEHYDE;NSC 337264;e-4-carboxaL;4-FORMYLINDOLE;INDOLE-4-ALDEHYDE;4-Formyl-1H-indole;RARECHEM AH BS 0110
- CBNumber:
- CB0217303
- Molecular Formula:
- C9H7NO
- Molecular Weight:
- 145.16
- MOL File:
- 1074-86-8.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/1 13:44:44
| Melting point | 139-143 °C(lit.) |
|---|---|
| Boiling point | 339.1±15.0 °C(Predicted) |
| Density | 1.278±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | DMF: 10 mg/ml; DMSO: 3 mg/ml; Ethanol: 10 mg/ml; Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml |
| form | powder to crystal |
| pka | 15.84±0.30(Predicted) |
| color | Light yellow to Brown |
| Water Solubility | Soluble in ethanol and acetone. Insoluble in water. |
| Sensitive | Air Sensitive |
| InChI | InChI=1S/C9H7NO/c11-6-7-2-1-3-9-8(7)4-5-10-9/h1-6,10H |
| InChIKey | JFDDFGLNZWNJTK-UHFFFAOYSA-N |
| SMILES | N1C2=C(C(C=O)=CC=C2)C=C1 |
| CAS DataBase Reference | 1074-86-8(CAS DataBase Reference) |
| NIST Chemistry Reference | 1H-indole-4-carboxaldehyde(1074-86-8) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H317-H319 | |||||||||
| Precautionary statements | P280-P301+P312+P330-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 22-36-43 | |||||||||
| Safety Statements | 26-36/37 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant/Keep Cold | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29333990 | |||||||||
| NFPA 704 |
|
Indole-4-carboxaldehyde price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 632422 | Indole-4-carboxaldehyde 97% | 1074-86-8 | 1G | ₹23999.03 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 632422 | Indole-4-carboxaldehyde 97% | 1074-86-8 | 1G | ₹23999.03 | 2022-06-14 | Buy |
| Sigma-Aldrich | 632422 | Indole-4-carboxaldehyde 97% | 1074-86-8 | 5G | ₹140627.58 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 632422 | Indole-4-carboxaldehyde 97% | 1074-86-8 | 5G | ₹140627.58 | 2022-06-14 | Buy |
| TCI Chemicals (India) | I0712 | Indole-4-carboxaldehyde min. 98.0 % | 1074-86-8 | 1G | ₹11600 | 2022-05-26 | Buy |
Indole-4-carboxaldehyde Chemical Properties,Uses,Production
Chemical Properties
White to dark brown solid
Uses
Indole-4-carboxaldehyde is usually used as reactant in Biginelli reaction,preparation of antitumor agents,intramolecular Friedel-Crafts acylation,preparation of inhibitors of cell division in E. Coli,synthesis of Hantzsch pyridine-containing Schiff bases.
General Description
Indole-4-carboxaldehyde participates in the synthesis of arcyriacyanin A. Synthesis of 4-indole-4-carboxaldehyde has been reported. Intramolecular Friedel-Crafts (FC) acylation of indole-4-carboxaldehyde has been reported.
Synthesis
Tetrapropylammonium perruthenate (0.3 g, 0.85 mmol) was added in portions to a mixture of alcohol product from 1H-Indole-4-Methanol (2.5 g, 17 mmol), N-methylmorpholine N-oxide (3.0 g, 25 mmol) and 4 A molecular sieves (3.0 g) in anhydrous methylene chloride (30 mL) at room temperature. The mixture was stirred at room temperature under nitrogen for 1 h and then filtered. The filtrate was concentrated in vacuo, and the residue was purified by chromatography (SiO2, CH2Cl2) to provide Indole-4-carboxaldehyde as a white powder (2.0 g, 80percent): 1H NMR (300 MHz, CDCl3) δ10.2 (s, 1H), 8.52 (br s, 1H), 7.64-7.69 (m, 2H), 7.31-7.44 (m, 3H), CI MS m/z=146 [C9H7NO+H]+.
Indole-4-carboxaldehyde Preparation Products And Raw materials
Raw materials
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| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| OCEAN TRADING CORPORATION | +91(22) 24921669 | New Delhi, India | 6211 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Hebei Fengmu Trading Co., Ltd. | +8613393234347 | China | 2996 | 58 | Inquiry |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | China | 29798 | 60 | Inquiry |
| Zhejiang ZETian Fine Chemicals Co. LTD | +8618957127338 | China | 2141 | 58 | Inquiry |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | China | 10318 | 58 | Inquiry |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | China | 39916 | 58 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49391 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29826 | 58 | Inquiry |
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