Biapenem

Biapenem Properties

Melting point	265-271°C (dec.)
alpha	D20 -32.9° (c = 0.5)
storage temp.	-20°C
solubility	H2O: ≥5mg/mL (warmed)
form	powder
color	white to beige
Water Solubility	H2O: ≥5mg/mL (warmed)
InChI	InChI=1/C15H18N4O4S/c1-7-11-10(8(2)20)14(21)19(11)12(15(22)23)13(7)24-9-3-17-5-16-6-18(17)4-9/h5-11,20H,3-4H2,1-2H3/t7-,8-,10-,11-/s3
InChIKey	MRMBZHPJVKCOMA-YJFSRANCSA-N
SMILES	C(C1=C([C@H](C)[C@]2([H])[C@@]([H])([C@H](O)C)C(=O)N12)SC1C[N+]2=CN=CN2C1)(=O)[O-] \|&1:3,5,7,9,r\|
CAS DataBase Reference	120410-24-4(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P313-P337+P313-P362-P403+P233-P405-P501
WGK Germany	3
HS Code	2941.90.5000

Biapenem price More Price(4)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	SML0306	Biapenem ≥98% (HPLC)	120410-24-4	10MG	₹8021.33	2022-06-14	Buy
Sigma-Aldrich(India)	SML0306	Biapenem ≥98% (HPLC)	120410-24-4	50MG	₹31987.88	2022-06-14	Buy
TCI Chemicals (India)	B5522	Biapenem	120410-24-4	25MG	₹3500	2022-05-26	Buy
TCI Chemicals (India)	B5522	Biapenem	120410-24-4	100MG	₹8800	2022-05-26	Buy

Product number	Packaging	Price	Buy
SML0306	10MG	₹8021.33	Buy
SML0306	50MG	₹31987.88	Buy
B5522	25MG	₹3500	Buy
B5522	100MG	₹8800	Buy

Biapenem Chemical Properties,Uses,Production

Description

Biapenem was introduced in Japan as a parenteral treatment for bacterial infections. This new 1-β-methylcarbapenem can be prepared by reaction of commercially available 4-nitrobenzyl protected β-methylcarbapenem enolphosphate with mercapto bicyclotriazolium chloride, obtained in 11 steps starting from hydrazine, followed by deprotection of the carboxylic acid function. Biapenem is a bacterial cell wall synthesis inhibitor with a broad spectrum in vitro antibacterial activity encompassing many Gramnegative and Gram-positive aerobic and anaerobic bacteria, including species producing β-lactamases. Like imipenem, biapenem is moderately active against fnferococcus faecalis and E. faecuirn and is inactive against methicillin-resistant Staphylococcus aureus. Biapenem is stable to hydrolysis by human renal dihydropeptidase I (DHP-I) and therefore does not require the coadministration of a DHP-I inhibitor. In clinical trials, biapenem showed good clinical and microbiological efficacy in the treatment of patients with intraabdominal, lower respiratory tract and complicated urinary tract infections. After intravenous administration, the drug is widely distributed, has linear pharmacokinetics and is mainly excreted in the urine with an elimination half-life of approximately 1 h. Biapenem is generally well tolerated, the most common adverse events being skin eruptions/rashes, nausea and diarrhea.

Chemical Properties

Off-White Solid

Uses

Biapenem is a carbapenem antibiotic. It has in vitro activity against anaerobes. Biapenem is a new parenteral carbapenem antibacterial agent with a broad spectrum of in vitro antibacterial activity encompassing many Gram-negative and Gram-positive aerobic

Antimicrobial activity

A semisynthetic carbapenem with a 2-substituted triazolium moiety. It has broad-spectrum activity against most aerobic and anaerobic Gram-positive and Gram-negative organisms. It is equivalent to, or slightly more active than, imipenem against Gram-negative aerobic bacteria and slightly less active than imipenem against Gram-positive organisms. It is stable to hydrolysis by dehydropeptidase. It is not hydrolyzed by most serine β-lactamases, but like all carbapenems and penems is readily hydrolyzed by carbapenemases. It penetrates into bronchial epithelial lining fluid with peak concentrations of 2.4–4.4 mg/L. The plasma half-life is 1.5–1.9 h. The potential for neurotoxicity is less than that of imipenem.

Clinical Use

Biapenem is a newer second-generation carbapenem withchemical and microbiological properties similar to those ofmeropenem. Thus, it has broad-spectrum antibacterial activitythat includes most aerobic Gram-negative and Grampositivebacteria and anaerobes. Biapenem is stable toDHP-I67 and resistant to most β-lactamases. It is claimedto be less susceptible to metallo-β-lactamases than eitherimipenem or meropenem. It is not active orally.

Biapenem Preparation Products And Raw materials

Raw materials

Preparation Products

Biapenem Suppliers

Global( 407)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
Honour Lab Limited	+919845977466	Telangana, India	164	58	Inquiry
Hetero Drugs Limited	+91-4023704923 +91-4023704923	Telangana, India	296	58	Inquiry
Kopran Ltd	+91-9920289074 +91-9820220525	Maharashtra, India	21	58	Inquiry
BDR Pharmaceuticals International Pvt Ltd	+91-2240560560 +91-7718884418	Maharashtra, India	206	58	Inquiry
BDR Pharmaceuticals International Pvt., Ltd.	91-22-40560560	Maharashtra, India	91	58	Inquiry
TCI Chemicals (India) Pvt. Ltd.	1800 425 7889	New Delhi, India	6768	58	Inquiry
Excel International	08048957044	Mumbai, India	36	58	Inquiry
Hetero Drugs Limited	08048372500Ext 439	Hyderabad, India	174	58	Inquiry
Pharma Affiliates	172-5066494	Haryana, India	6754	58	Inquiry
Manus Aktteva Biopharma LLP	08048250218Ext 800	Ahmedabad, India	655	58	Inquiry

Supplier	Advantage
Honour Lab Limited	58
Hetero Drugs Limited	58
Kopran Ltd	58
BDR Pharmaceuticals International Pvt Ltd	58
BDR Pharmaceuticals International Pvt., Ltd.	58
TCI Chemicals (India) Pvt. Ltd.	58
Excel International	58
Hetero Drugs Limited	58
Pharma Affiliates	58
Manus Aktteva Biopharma LLP	58

Biapenem Spectrum

Biapenem(120410-24-4)MS

120410-24-4(Biapenem)Related Search:

Thiophanate-methyl METSULFURON METHYL Tribenuron methyl Methyl acetate 2-(METHYLSULFONYL)ETHANOL

Methyl salicylate Kresoxim-methyl Methyl BIAPENEM SIDE CHAIN Carboxy styrene-butadiene latex

Methyl bromide (AZETIDIN-3-YL)METHANOL Thienamycin beta-Methyl vinyl phosphate (MAP) (+/-)-4-Methyl-2-azetidinone

ISO-BUTYL ISO-PROPYL SULFIDE 4-Isopropyl-2-azetidinone Biapenem

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6-[[(4r,5s,6s)-2-carboxy-6-[(1r)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-en-3-yl]thio]-6,7-dihydro-5h-pyrazolo[1,2-a][1,2,4]triazol-4-ium inner salt BIAPENEM (4R,5S,6S)-3-(6,7-dihydro-5H-pyrazolo[1,2-a][1,2,4]triazol-4-ium-6-ylthio)-6-((R)-1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate 6-[[(4R,5S,6S)-2-Carboxylato-6β-[(1R)-1-hydroxyethyl]-4α-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-en-3-yl]thio]-6,7-dihydro-5H-pyrazolo[1,2-a]-s-triazol-4-ium 6-[[(4R,5S,6S)-2-Carboxylato-6β-[(R)-1-hydroxyethyl]-4α-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-en-3-yl]thio]-6,7-dihydro-5H-pyrazolo[1,2-a][1,2,4]triazol-4-ium 6-[[(4R,5β)-2-Carboxylato-4α-methyl-6β-[(R)-1-hydroxyethyl]-7-oxo-1-azabicyclo[3.2.0]hept-2-en-3-yl]thio]-6,7-dihydro-5H-pyrazolo[1,2-a][1,2,4]triazol-4-ium L-627 LJC-10627 protected biapenum protected biapenem Biapenem ,98% Crude Grade 6-{[(4R,5S,6S)-2-carboxylato-6-[(1R)-1-hydroxyethyl]-4-Methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-en-3-yl]sulfanyl}-5H,6H,7H-2,4000000$l^{5},8000000-pyrazolo[1,2-a][1$l^{5},2,4]triazol-4-yliuM 6-[[(4R,5S,6S)-2-Carboxylato-6β-[(1R)-1-hydroxyethyl]-4α-Methyl-7-oxo-1-azabicyclo[3.2.0]he Biapenern OMegacin BiapeneM Crude CL 186815 CL 186-815 BiapeneM USP 5H-Pyrazolo[1,2-a][1,2,4]triazol-4-ium, 6-[[(4R,5S,6S)-2-carboxy-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-en-3-yl]thio]-6,7-dihydro-, inner salt Biapenem, >=99% Biapenem CAS:120410-24-4 L-627; LJC 10627 Biapenem (GMP) CS-1393 Biapenem for Injection (155835-09-9) biapenem 6-(7-oxo-1-azabicyclo[3.2.0]hept-2-en-6-yl)-1-azabicyclo[3.2.0]hept-2-en-7-one Biapenem Biapenem CLI 86815 Biapenem USP/EP/BP Biapenem Impurity 13 Biapenem (CLI 86815) BiapenemQ: What is Biapenem Q: What is the CAS Number of Biapenem Q: What is the storage condition of Biapenem Q: What are the applications of Biapenem Biapenem Powder Biapenem Powder USP Standard Biapenem AKSci M048 120410-24-4 153835-09-9 120410-42-4 20410-24-4 C15H18N4O4S Inhibitors L-627, LJC 10627 Chiral Compounds Intermediates & Fine Chemicals Pharmaceuticals Sulfur & Selenium Compounds Pharmaceutical intermediate Pharmaceutical raw material pharmaceutical intermediates API chiral Antibacterial APIs