A77 1726
- CAS No.
- 163451-81-8
- Chemical Name:
- A77 1726
- Synonyms
- Flucyamide;A77 1726 (Teriflunomide);2-Butenamide, 2-cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-, (2Z)-;A 1726;HMR 1726;Teriflunomide(b);Teriflunomide (cGMP);Leflunomide Impurity B;LeflunoMide EP IMpurity B;A-771726;A 771726;A771726
- CBNumber:
- CB02486749
- Molecular Formula:
- C12H9F3N2O2
- Molecular Weight:
- 270.21
- MOL File:
- 163451-81-8.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/5/29 17:48:59
| Melting point | 229-232°C |
|---|---|
| Boiling point | 410.8±45.0 °C(Predicted) |
| Density | 1.424±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | DMSO: soluble5mg/mL, clear (warmed) |
| pka | 5.20±0.50(Predicted) |
| form | powder |
| color | white to beige |
| λmax | 203nm(MeOH)(lit.) |
| Merck | 14,9165 |
| Stability | Hygroscopic |
| InChIKey | UTNUDOFZCWSZMS-YFHOEESVSA-N |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H225-H302+H312+H332-H319 | |||||||||
| Precautionary statements | P210-P280-P301+P312-P303+P361+P353-P304+P340+P312-P305+P351+P338 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 2926.90.4801 | |||||||||
| NFPA 704 |
|
A77 1726 price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | SML0936 | Teriflunomide ≥98% (HPLC) | 163451-81-8 | 10MG | ₹7079.55 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | T-122 | Teriflunomide solution 1?mg/mL in acetonitrile, certified reference material, ampule of 1?mL | 163451-81-8 | 1ML | ₹14337.4 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | SML0936 | Teriflunomide ≥98% (HPLC) | 163451-81-8 | 50MG | ₹29011 | 2022-06-14 | Buy |
| TCI Chemicals (India) | T3287 | Teriflunomide min. 98.0 % | 163451-81-8 | 100MG | ₹5100 | 2022-05-26 | Buy |
| TCI Chemicals (India) | T3287 | Teriflunomide min. 98.0 % | 163451-81-8 | 1G | ₹17400 | 2022-05-26 | Buy |
A77 1726 Chemical Properties,Uses,Production
Description
In September 2012, the US FDA approved teriflunomide (also referred to as HMR-1726) as a therapy for patients with relapsing forms of multiple sclerosis (MS). Teriflunomide is the second approved oral treatment option for MS, after Gilenya? which was approved in 2010. Teriflunomide, which is the active metabolite of leflunomide (a marketed drug for the treatment of rheumatoid and psoriatic arthritis), is a non?competitive and selective inhibitor of dihydroorotate dehydrogenase (DHODH), the rate-limiting enzyme in the de novo synthesis of pyrimidines. Although the net effect of inhibition of DHODH by teriflunomide and its therapeutic effect in MS are not clear, it is hypothesized that by inhibiting de novo pyrimidine synthesis, the effector functions of activated lymphocytes are suppressed, thus dampening the effect of an overactive immune system.
Chemical Properties
White Solid
Uses
The active metabolite of Leflunomide, a potent disease-modifying antirheumatic drug used in the treatment of rheumatoid arthritis. LEF-M interferes with dendritic cell function.
Definition
ChEBI: An enamide obtained by formal condensation of the carboxy group of (2Z)-2-cyano-3-hydroxybut-2-enoic acid with the anilino group of 4-(trifluoromethyl)aniline. Used for the treatment of relapsing forms of multiple sclerosis and rheumatoid arthritis.
General Description
Teriflunomide, marketed under the trade name Aubagio, is the active metabolite of leflunomide, an immunosuppressive disease-modifying antirheumatic drug, used in active moderate-to-severe rheumatoid arthritis and psoriatic arthritis. An analytical reference standard for use in LC/MS or GC/MS applications including clinical and diagnostic testing such as therapeutic drug monitoring assays.
A77 1726 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| KARPSCHEM LABORATORIES | +91-7249203006 +91-7249203006 | Maharashtra, India | 786 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Triveni Interchem Private Limited (Group Of Triveni... | 08046042087 | Gujarat, India | 497 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| Chemicea Pharmaceuticals Pvt Ltd | +91-9881765045/+91-8796656135 | Pune, India | 825 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Hebei Duling International Trade Co. LTD | +8617333973358 | China | 15437 | 58 | Inquiry |