A77 1726
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- ₹5100 - ₹29011
- Product name: A77 1726
- CAS: 163451-81-8
- MF: C12H9F3N2O2
- MW: 270.21
- EINECS:642-273-4
- MDL Number:MFCD00910058
- Synonyms:A 1726;HMR 1726;(Z)-2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-butenamide;LeflunoMide EP IMpurity B;Leflunomide Impurity 2(Leflunomide EP Impurity B);A-771726;A 771726;A771726;A-771726;A 77-1726;A771726;HMR-1726;(2Z)-2-Cyano-3-hydroxy-N-[4-(triflu
5 prices
Selected condition：
Brand
- TCI Chemicals (India)
- Sigma-Aldrich(India)
Package
- 10MG
- 50MG
- 100MG
- 1G
- 1ML
- ManufacturerTCI Chemicals (India)
- Product numberT3287
- Product descriptionTeriflunomide min. 98.0 %
- Packaging100MG
- Price₹5100
- Updated2022-05-26
- Buy
- ManufacturerTCI Chemicals (India)
- Product numberT3287
- Product descriptionTeriflunomide min. 98.0 %
- Packaging1G
- Price₹17400
- Updated2022-05-26
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberSML0936
- Product descriptionTeriflunomide ≥98% (HPLC)
- Packaging10MG
- Price₹7079.55
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberT-122
- Product descriptionTeriflunomide solution 1?mg/mL in acetonitrile, certified reference material, ampule of 1?mL
- Packaging1ML
- Price₹14337.4
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberSML0936
- Product descriptionTeriflunomide ≥98% (HPLC)
- Packaging50MG
- Price₹29011
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| TCI Chemicals (India) | T3287 | Teriflunomide min. 98.0 % | 100MG | ₹5100 | 2022-05-26 | Buy |
| TCI Chemicals (India) | T3287 | Teriflunomide min. 98.0 % | 1G | ₹17400 | 2022-05-26 | Buy |
| Sigma-Aldrich(India) | SML0936 | Teriflunomide ≥98% (HPLC) | 10MG | ₹7079.55 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | T-122 | Teriflunomide solution 1?mg/mL in acetonitrile, certified reference material, ampule of 1?mL | 1ML | ₹14337.4 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | SML0936 | Teriflunomide ≥98% (HPLC) | 50MG | ₹29011 | 2022-06-14 | Buy |
Properties
Melting point :229-232°C
Boiling point :410.8±45.0 °C(Predicted)
Density :1.424±0.06 g/cm3(Predicted)
storage temp. :-20°C
solubility :DMSO: soluble5mg/mL, clear (warmed)
pka :5.20±0.50(Predicted)
form :powder
color :white to beige
λmax :203nm(MeOH)(lit.)
Merck :14,9165
Stability :Hygroscopic
InChIKey :UTNUDOFZCWSZMS-YFHOEESVSA-N
Boiling point :410.8±45.0 °C(Predicted)
Density :1.424±0.06 g/cm3(Predicted)
storage temp. :-20°C
solubility :DMSO: soluble5mg/mL, clear (warmed)
pka :5.20±0.50(Predicted)
form :powder
color :white to beige
λmax :203nm(MeOH)(lit.)
Merck :14,9165
Stability :Hygroscopic
InChIKey :UTNUDOFZCWSZMS-YFHOEESVSA-N
Safety Information
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| Signal word: | Warning | |||||||||||||||||||||
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Description
A-771726 is the active metabolite of leflunomide, a prodrug approved by the FDA for treatment of rheumatoid arthritis. A-771726 reversibly inhibits dihydroorotate dehydrogenase, the rate-limiting step in the de novo synthesis of pyrimidines. It prevents activated lymphocytes from accumulating sufficient pyrimidines to support DNA synthesis (IC50s = 0.09, 3.5, and 12.5 μM for rat, mouse, and human, respectively). At higher doses, A-771726 inhibits tyrosine kinases responsible for early T cell and B cell signaling in the G0/G1 phase of the cell cycle. A-771726 has also been shown to inhibit the production of prostaglandin E2 in synoviocytes activated by TNF-α and IL-1α (IC50s = 7 and 3 μM, respectively) as well as inhibit MMP-1 and IL-6 production at concentrations >10 μM.More related product prices
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