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ChemicalBook > Product Catalogue >API >Antipyretic analgesics >Nonsteroidal Anti-Inflammatory Drugs (NSAIDS) >Leflunomide

Leflunomide

Leflunomide Structure
  • ₹2000 - ₹28848.63
  • Product name: Leflunomide
  • CAS: 75706-12-6
  • MF: C12H9F3N2O2
  • MW: 270.21
  • EINECS:616-254-6
  • MDL Number:MFCD00867593
  • Synonyms:LEFLUNOMIDE;HWA 486;ALPHA,ALPHA,ALPHA-TRIFLUORO-5-METHYL-4-ISOXAZOLECARBOXY-P-TOLUIDIDE;5-METHYLISOXAZOLE-4-(4-TRIFLUOROMETHYLCARBOXANILIDE);5-METHYL-N-[4-(TRIFLUOROMETHYL)PHENYL]-4-ISOXAZOLECARBOXAMIDE;N-(4-TRIFLUOROMETHYLPHENYL)-5-METHYLISOXAZOL-4-CARBOXAMIDE;5-methylisoxazole-4-carboxylicacid(4-trifluoromethyl)anilide ;5-methyl-n-(4-(trifluoromethyl)phenyl)-4-isoxazolecarboxamid
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Brand

  • TCI Chemicals (India)
  • Sigma-Aldrich(India)

Package

  • 25MG
  • 100MG
  • 200MG
  • 1G
  • ManufacturerTCI Chemicals (India)
  • Product numberL0250
  • Product descriptionLeflunomide
  • Packaging200MG
  • Price₹2000
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberL0250
  • Product descriptionLeflunomide
  • Packaging1G
  • Price₹7400
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberL5025
  • Product descriptionLeflunomide Immunosuppressant
  • Packaging25MG
  • Price₹8952.28
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberPHR1378
  • Product descriptionLeflunomide Pharmaceutical Secondary Standard; Certified Reference Material
  • Packaging1G
  • Price₹9093
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberL5025
  • Product descriptionLeflunomide Immunosuppressant
  • Packaging100MG
  • Price₹28848.63
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) L0250 Leflunomide 200MG ₹2000 2022-05-26 Buy
TCI Chemicals (India) L0250 Leflunomide 1G ₹7400 2022-05-26 Buy
Sigma-Aldrich(India) L5025 Leflunomide Immunosuppressant 25MG ₹8952.28 2022-06-14 Buy
Sigma-Aldrich(India) PHR1378 Leflunomide Pharmaceutical Secondary Standard; Certified Reference Material 1G ₹9093 2022-06-14 Buy
Sigma-Aldrich(India) L5025 Leflunomide Immunosuppressant 100MG ₹28848.63 2022-06-14 Buy

Properties

Melting point :166.5 °C
Boiling point :289.3±40.0 °C(Predicted)
Density :1.392±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :Practically insoluble in water, freely soluble in methanol, sparingly soluble in methylene chloride.
form :Solid
pka :10.8(at 25℃)
color :White
Merck :14,5432
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
InChIKey :VHOGYURTWQBHIL-UHFFFAOYSA-N
CAS DataBase Reference :75706-12-6(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Leflunomide is a synthetic isoxazol derivative that regulates T lymphocyte progression through the cell cycle by selectively inhibiting de novo pyrimidine synthesis. As a prodrug, it is rapidly converted to its active open ring metabolite, A-771726 , which inhibits human lymphocyte proliferation with an IC50 value of 12.5 μM, in vitro. Leflunomide has been evaluated in phase II and III clinical trials for efficacy in slowing the disease progression of rheumatoid arthritis. It has also been used as an immunosuppressant agent to prevent rejection of transplant allografts and xenografts.

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