N-Methylbenzamide
- CAS No.
- 613-93-4
- Chemical Name:
- N-Methylbenzamide
- Synonyms
- 1MVR;N-Methylbenzenamide;Benzamide, N-methyl-;n-methyl-benzamid;N-METHYLBENZAMIDE;N-METHYLBENZAMIDE, 99+%;n-methylbenzenecarboxamide;N-MethylbenzaMide, 99+% 10GR;Benzamide, N-methyl- (6CI,7CI,8CI,9CI)
- CBNumber:
- CB0273752
- Molecular Formula:
- C8H9NO
- Molecular Weight:
- 135.16
- MOL File:
- 613-93-4.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/8/21 22:41:43
| Melting point | 76-78 °C (lit.) |
|---|---|
| Boiling point | 167 °C/11 mmHg (lit.) |
| Density | 1.1031 (rough estimate) |
| refractive index | 1.5589 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | ethanol: soluble50mg/mL, clear, yellow-green |
| pka | 15.00±0.46(Predicted) |
| form | Solid |
| color | White to off-white |
| Water Solubility | Insoluble in water. |
| InChI | InChI=1S/C8H9NO/c1-9-8(10)7-5-3-2-4-6-7/h2-6H,1H3,(H,9,10) |
| InChIKey | NCCHARWOCKOHIH-UHFFFAOYSA-N |
| SMILES | C(NC)(=O)C1=CC=CC=C1 |
| CAS DataBase Reference | 613-93-4(CAS DataBase Reference) |
| EPA Substance Registry System | N-Methylbenzamide (613-93-4) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 20/21/22-22 | |||||||||
| Safety Statements | 24/25 | |||||||||
| WGK Germany | 1 | |||||||||
| RTECS | CV5570000 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29242990 | |||||||||
| NFPA 704 |
|
N-Methylbenzamide price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 222798 | N-Methylbenzamide ≥99% | 613-93-4 | 5G | ₹7112.03 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 222798 | N-Methylbenzamide ≥99% | 613-93-4 | 5G | ₹7112.03 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 222798 | N-Methylbenzamide ≥99% | 613-93-4 | 10G | ₹10803.35 | 2022-06-14 | Buy |
| ALFA India | ALF-A18057-22 | N-Methylbenzamide, 99% | 613-93-4 | 100g | ₹61590 | 2022-05-26 | Buy |
| ALFA India | ALF-A18057-14 | N-Methylbenzamide, 99% | 613-93-4 | 25g | ₹8479 | 2022-05-26 | Buy |
N-Methylbenzamide Chemical Properties,Uses,Production
Chemical Properties
N-methylbenzamide is an off-white crystalline solid.
Uses
N-Methylbenzamide is an important pesticide intermediate. It acts as a potent PDE10A (phosphodiesterase with a remarkable localization as the protein is abundant only in brain tissue) inhibitor.
Air & Water Reactions
Insoluble in water.
Reactivity Profile
N-METHYLBENZAMIDE is an amide. Amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).
Fire Hazard
Flash point data concerning N-METHYLBENZAMIDE are not available, however, N-METHYLBENZAMIDE is probably combustible.
Synthesis
Add benzoic acid (977 mg, 8 mmol), dry DCM (20 mL) and catalytic amount of DMF in a 100 mL round-bottom flask. Cool the reaction mixture to 0°C and stir for 5 minutes. Add (COCl)2 (0.89 mL, 1.3 equiv.) dropwise to the reaction mixture and stir at room temperature for 4 hours. Concentrate the resulting mixture under reduced pressure to obtain acid chloride. Add catalytic amount of 4-dimethylaminopyridine, dry DCM (15 mL), MeNH2 (2 (M) in THF) (5.19 mL, 1.3 equiv.) and Et3N (1.56 mL, 1.4 equiv.) to the mixture in a 100 mL round-bottom flask. Cool the reaction mixture to 0°C. Add acid chloride (1.0 equiv.) dropwise at 0°C. Stir the reaction mixture at room temperature for 12 hours. Add water (40 mL) and seperate the organic layer. Extract the aqueous layer with DCM (3 x 30 mL). Wash the combined organic layer with saturated aqueous NaHCO3 (30 mL) solution followed by water (30 mL). Dry the organic layer over Na2SO4 and concentrated under reduced pressure. Purify the crude mass by silica gel column chromatography (20% ethyl acetate in hexane as eluent) to obtain N-methylbenzamide. DOI: 10.1002/anie.202203539
N-Methylbenzamide Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| JSK Chemicals | +919879767970 | Gujarat, India | 3756 | 58 | Inquiry |
| ALS INDIA LIFE SCIENCES | +91-8977036379 +91-8977036379 | Hyderabad, India | 1879 | 58 | Inquiry |
| CHEMSWORTH | +91-261-2397244 | New Delhi, India | 6707 | 30 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| Alfa Aesar | 1 800 209 7001 | Maharashtra, India | 6913 | 58 | Inquiry |
| Anand Agencies | 91-20-24454597 | Maharashtra, India | 2337 | 58 | Inquiry |
| Metropolitan Eximchem Pvt., Ltd. (Metropolitan Group) | 91-22-24081528 | Maharashtra, India | 70 | 58 | Inquiry |
| ASM Organics | 91-9866122393 | Andhra Pradesh, India | 1188 | 58 | Inquiry |
| Metropolitan Eximchem Ltd. | 91 22 408 1529 | New Delhi, India | 148 | 38 | Inquiry |
| Avra Synthesis Pvt Ltd | +914027175796 | New Delhi, India | 1606 | 30 | Inquiry |
| Supplier | Advantage |
|---|---|
| JSK Chemicals | 58 |
| ALS INDIA LIFE SCIENCES | 58 |
| CHEMSWORTH | 30 |
| A.J Chemicals | 58 |
| Alfa Aesar | 58 |
| Anand Agencies | 58 |
| Metropolitan Eximchem Pvt., Ltd. (Metropolitan Group) | 58 |
| ASM Organics | 58 |
| Metropolitan Eximchem Ltd. | 38 |
| Avra Synthesis Pvt Ltd | 30 |
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