Hippuric acid
- CAS No.
- 495-69-2
- Chemical Name:
- Hippuric acid
- Synonyms
- hippurate;BENZOYLGLYCINE;hippuric;AKOS B029712;Hippursaeure;Benzamidoacetic acid;CPD-425;NSC 9982;BZ-GLY-OH;BZO-GLY-OH
- CBNumber:
- CB0483177
- Molecular Formula:
- C9H9NO3
- Molecular Weight:
- 179.17
- MOL File:
- 495-69-2.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/8/24 19:19:26
| Melting point | 187-191 °C (lit.) |
|---|---|
| Boiling point | 311.69°C (rough estimate) |
| Density | 1,371 g/cm3 |
| refractive index | 1.5600 (estimate) |
| storage temp. | Store below +30°C. |
| solubility | 3.26g/l |
| pka | 3.62(at 25℃) |
| form | Crystalline Powder |
| color | White to almost white |
| PH | 2.5-3.5 (10g/l, H2O, 20℃)(slurry) |
| Water Solubility | Soluble in water. |
| Merck | 14,4716 |
| BRN | 1073987 |
| Stability | Stable. Incompatible with oxidizing agents. |
| InChIKey | QIAFMBKCNZACKA-UHFFFAOYSA-N |
| LogP | 0.771 |
| CAS DataBase Reference | 495-69-2(CAS DataBase Reference) |
| EPA Substance Registry System | Glycine, N-benzoyl- (495-69-2) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H315-H318-H335-H319 | |||||||||
| Precautionary statements | P280a-P304+P340-P405-P501a-P264-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P261-P280-P305+P351+P338 | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 22-37/38-41-36/37/38 | |||||||||
| Safety Statements | 26-39-36/37-22 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | MR8150000 | |||||||||
| F | 3-10 | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29242990 | |||||||||
| NFPA 704 |
|
Hippuric acid price More Price(14)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 8.20649 | Hippuric acid for synthesis | 495-69-2 | 100G | ₹5350 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 112003 | Hippuric acid 98% | 495-69-2 | 5G | ₹2045.93 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 8.20649 | Hippuric acid for synthesis | 495-69-2 | 500G | ₹9850.01 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 112003 | Hippuric acid 98% | 495-69-2 | 100G | ₹5444.98 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 112003 | Hippuric acid 98% | 495-69-2 | 500G | ₹5672.3 | 2022-06-14 | Buy |
Hippuric acid Chemical Properties,Uses,Production
Chemical Properties
White crystalline powder
Uses
N-Benzoylglycine also known as Hippuric Acid is the glycine conjugate of benzoic acid commonly found in ruminant urine. It is synthesized in the liver and its production is greatly increased following consuption of benzoic acid. In itself it does not have a direct biological function, however p-hydroxy-hippurica acid can be used as an inhibitor of Ca2+ ATPase.
Definition
ChEBI: An N-acylglycine in which the acyl group is specified as benzoyl.
Preparation
Preparation of Hippuric acid from Glycine.
Principle: The hydroxy and amino functions can be easily benzoylated using Benzoyl chloride in aqueous alkaline conditions. This reaction is known as Schotten-Baumann reaction.
Reaction:
Procedure: Dissolve 0.5 g of glycine in 5 ml of 10% NaOH solution in a 25 ml conical flask. Add 0.9 ml of benzoyl chloride in five portions to the solution. Stopper the flask and shake vigorously after each addition until all the benzoyl chloride is reacted. Transfer the solution to a beaker and add few grams of ice and add conc. HCl slowly with stirring until the solution is acidic to litmus paper. Filter the crystalline precipitate of the product on a Buchner funnel, wash with cold water and drain well. Place the solid in a conical flask with 10 ml CCl4 and boil gently for 10 min. Allow the mixture to cool slightly, filter under gentle suction and wash with 10-20 ml CCl4. Record the practical yield and re-crystallize it.
Re-crystallization: Dissolve the crude product from boiling water (5 ml), with addition of decolorizing charcoal if necessary, filter the hot solution and cool the filtrate. The crystals of the product separate out. Filter, dry and record the melting point and TLC [using Butanal : acetic acid: water (4 : 1 : 1) as solvent or CHCl3:methanol (9 : 1) or toluene].
Purification Methods
Crystallise the acid from boiling H2O. Dry it over P2O5. Also purify it by dissolving 135-140g in 2L of boiling H2O, filtering through a steam-heated funnel and allowing to crystallise at ~20o (yield 115-122g first crop, m 186-187o). [Ingersoll & Babcock Org Synth Coll Vol II 328 1943, Beilstein 9 225, I 100.]
Hippuric acid Preparation Products And Raw materials
Raw materials
Preparation Products
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chevron_right| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| GLR Innovations | +91 9891111994 | New Delhi, India | 4542 | 58 | Inquiry |
| NSR Laboratories Pvt. Ltd. | +91-9866989891 +91-9000457345 | Hyderabad, India | 196 | 58 | Inquiry |
| SVH BIOSCIENCES | +91-6303499280 +91-6303499280 | Hyderabad, India | 478 | 58 | Inquiry |
| AMINO ORGANICS | +919866989891 | Hyderabad, India | 275 | 58 | Inquiry |
| Paras Intermediates Private Limited | +91-2228202847 +91-9820230660 | Maharashtra, India | 11 | 58 | Inquiry |
| Aditya Chemicals | +91-9825237294 +91-9909971523 | Gujarat, India | 38 | 58 | Inquiry |
| Santo Righello Pvt. Ltd | 91-9885571757 | Hyderabad, India | 919 | 58 | Inquiry |
| Clearsynth Labs | 91-22-45045900 | Maharashtra, India | 3889 | 58 | Inquiry |
| Thomas Baker (Chemicals) Pvt. Ltd. (TBCPL) | 91-22-22811264 | Maharashtra, India | 74 | 58 | Inquiry |
| VASIN BIO LIFE SCIENCES PVT LTD | 9491644688 | Hyderabad, India | 2096 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| GLR Innovations | 58 |
| NSR Laboratories Pvt. Ltd. | 58 |
| SVH BIOSCIENCES | 58 |
| AMINO ORGANICS | 58 |
| Paras Intermediates Private Limited | 58 |
| Aditya Chemicals | 58 |
| Santo Righello Pvt. Ltd | 58 |
| Clearsynth Labs | 58 |
| Thomas Baker (Chemicals) Pvt. Ltd. (TBCPL) | 58 |
| VASIN BIO LIFE SCIENCES PVT LTD | 58 |
Related articles
- Physiology of Hippuric acid
- Hippuric Acid is an acyl glycine produced by the conjugation of benzoic acid and glycine, found as a normal component in urine....
- Apr 14，2022
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