4-Aminohippuric acid
- CAS No.
- 61-78-9
- Chemical Name:
- 4-Aminohippuric acid
- Synonyms
- PAH;P-AMINOHIPPURIC ACID;POLYNUCLEAR AROMATIC HYDROCARBONS;paha;Nefrotest;N-glycine;Aminohippuric;pah(aminoacid);AKOS BBS-00006940;p-amino-hippuricaci
- CBNumber:
- CB5348161
- Molecular Formula:
- C9H10N2O3
- Molecular Weight:
- 194.19
- MOL File:
- 61-78-9.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/4/25 17:59:01
| Melting point | 199-200 °C (dec.)(lit.) |
|---|---|
| Boiling point | 330.62°C (rough estimate) |
| Density | 1.356 |
| refractive index | 1.5600 (estimate) |
| storage temp. | Store below +30°C. |
| solubility | DMF: 33 mg/ml; DMF:PBS (pH7.2) (1:30): 0.03 mg/ml; DMSO: 20 mg/ml |
| pka | pKa 3.8 (Uncertain) |
| form | Crystalline Powder |
| color | Off-white to grayish |
| PH | 3.0-3.5 (20g/l, H2O, 20℃) |
| Water Solubility | Soluble in alcohol, chloroform, benzene, and acetone. Insoluble in water, ether, carbon, and tetrachloride. |
| Merck | 14,442 |
| BRN | 1213676 |
| InChIKey | HSMNQINEKMPTIC-UHFFFAOYSA-N |
| CAS DataBase Reference | 61-78-9(CAS DataBase Reference) |
| EPA Substance Registry System | P-Aminohippuric acid (61-78-9) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 36/37/38-20/21/22 | |||||||||
| Safety Statements | 37/39-26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 8-9-23 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29242990 | |||||||||
| NFPA 704 |
|
4-Aminohippuric acid price More Price(10)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | A1422 | p-Aminohippuric acid ≥99% | 61-78-9 | 10G | ₹5758.9 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | A1422 | p-Aminohippuric acid ≥99% | 61-78-9 | 25G | ₹10413.65 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR3174 | Aminohippuric Acid pharmaceutical secondary standard, certified reference material | 61-78-9 | 500MG | ₹18380.85 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | A1422 | p-Aminohippuric acid ≥99% | 61-78-9 | 100G | ₹28707.9 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | A1422 | p-Aminohippuric acid ≥99% | 61-78-9 | 250G | ₹63088.1 | 2022-06-14 | Buy |
4-Aminohippuric acid Chemical Properties,Uses,Production
Description
4-Aminohippuric acid is a substrate for various renal transporters that has been used in the study of anion uptake in the kidney. It is a substrate for organic anion transporter 1 (OAT1; Km = 14.3 μM in X. laevis oocytes), the human inorganic phosphate transporter (NPT1; Km = 2.66 mM in HEK293 cells), and apical multidrug resistance protein (MDR2; Km = 880 μM in HEK293 cells). 4-Aminohippuric acid is a glycine amide form of 4-aminobenzoic acid . Formulations containing 4-aminohippuric acid have been used as markers to determine renal plasma flow.
Chemical Properties
off-white to greyish crystalline powder
Uses
4-Aminohippuric Acid is used in the measurement of renal plasma flow as a diagnostic tool which may be applied towards kidney disorders.
Definition
ChEBI: P-aminohippuric acid is an N-acylglycine that is the 4-amino derivative of hippuric acid; used as a diagnostic agent in the measurement of renal plasma flow. It has a role as a Daphnia magna metabolite. It is a conjugate acid of a p-aminohippurate.
General Description
Renal tubules secretes para amino hippuric acid/PAH.
Biochem/physiol Actions
Para-aminohippuric acid(PAH) is used as a marker in nutrition studies to measure the flow of blood in pigs, which inturn helps to determine the portal-drained viscera (PDV) flux of nutrients.
Synthesis
4-Aminohippuric acid is prepared by reacting p-nitrobenzoyl chloride with glycine, followed by reducing the p-nitro group with tin and hydrochloric acid.
Purification Methods
Crystallise the acid from H2O. It is soluble in organic solvents. [Cohen & McGilvery J Biol Chem 169 119 1945, 171 121 1947, Meunzen et al. J Biol Chem 26 469 1926, Beilstein 14 III 1069, 14 IV 1152.]
References
[1] B. ZMBOVA . Synthesis of p-aminohippuric acid analog and its labeling by technetium-99m[J]. International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes, 1989, 40 3: Pages 225-234. DOI:10.1016/0883-2889(89)90152-4.
[2] W P DEISS P P C. Studies in para-aminohippuric acid synthesis in the human: its application as a liver function test.[J]. Journal of Clinical Investigation, 1950, 29 8: 1014-1020. DOI:10.1172/JCI102332.
[3] M. SHEAT M. M Zenab F Saeed. Synthesis of Some of Azo, Triazines and Schiff Bases Compounds from 4-Aminohippuric Acid[J]. Journal of Education Science, 2009, 47 1: 1-8. DOI:10.33899/edusj.2009.57930.
[4] T SEKINE. Expression cloning and characterization of a novel multispecific organic anion transporter.[J]. The Journal of Biological Chemistry, 1997, 272 30: 18526-18529. DOI:10.1074/jbc.272.30.18526.
[5] HIROSHI UCHINO . p-Aminohippuric Acid Transport at Renal Apical Membrane Mediated by Human Inorganic Phosphate Transporter NPT1[J]. Biochemical and biophysical research communications, 2000, 270 1: Pages 254-259. DOI:10.1006/bbrc.2000.2407.
4-Aminohippuric acid Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| SVH BIOSCIENCES | +91-6303499280 +91-6303499280 | Hyderabad, India | 478 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Maas Pharma Chemicals | +91-9958666224 | Delhi, India | 1607 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| Reax Chemicals | 08048372701Ext 416 | Hyderabad, India | 4223 | 58 | Inquiry |
| Alfa Aesar | 1 800 209 7001 | Maharashtra, India | 6913 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Clearsynth Labs | 91-22-45045900 | Maharashtra, India | 3889 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| Shambhavi Enterprises | +91 251 2212444 | Mumbai, India | 54 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| SVH BIOSCIENCES | 58 |
| TCI Chemicals (India) Pvt. Ltd. | 58 |
| Maas Pharma Chemicals | 58 |
| A.J Chemicals | 58 |
| Reax Chemicals | 58 |
| Alfa Aesar | 58 |
| Pharmaffiliates Analytics and Synthetics P. Ltd | 58 |
| Clearsynth Labs | 58 |
| Pharma Affiliates | 58 |
| Shambhavi Enterprises | 58 |
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