Uric acid
- CAS No.
- 69-93-2
- Chemical Name:
- Uric acid
- Synonyms
- 7,9-Dihydro-1H-purine-2,6,8(3H)-trione;TRIKETOPURINE;2,6,8-TRIHYDROXYPURINE;Uric aci;NSC 3975;URIC ACID;URIC OXIDE;UricAcidGr;LITHIC ACID;URIC ACID(RG)
- CBNumber:
- CB9681462
- Molecular Formula:
- C5H4N4O3
- Molecular Weight:
- 168.11
- MOL File:
- 69-93-2.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/6/29 13:26:38
| Melting point | >300 °C (lit.) |
|---|---|
| Boiling point | 297.02°C (rough estimate) |
| Density | 1,9 g/cm3 |
| refractive index | 1.9900 (estimate) |
| storage temp. | Sealed in dry,2-8°C |
| solubility | Aqueous Base (Sparingly, Heated) |
| form | crystalline |
| pka | 3.89(at 12℃) |
| color | White to off-white |
| Odor | Odorless |
| Water Solubility | Soluble in 1M sodium hydroxide solution. Slightly soluble in water. Insoluble in ether and alcohol. |
| Merck | 14,9875 |
| BRN | 156158 |
| Stability | Stable. Incompatible with acids, bases, oxidising agents. |
| LogP | -1.730 (est) |
| CAS DataBase Reference | 69-93-2(CAS DataBase Reference) |
| EPA Substance Registry System | Uric acid (69-93-2) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H332-H335 | |||||||||
| Precautionary statements | P261-P280-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 33-36/37/38 | |||||||||
| Safety Statements | 24/25-36-26 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | YU7050080 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29339900 | |||||||||
| Toxicity | A nitrogenous end product and the principal excretory product of purine metabolism in mammals. In birds and reptiles, it is the principal end product of nitrogen metabolism in general. Defects in uric acid metabolism and excretion appear to be associated with a number of disease states, and it frequently occurs as a component of renal calculi. It has not been associated closely with toxic insults except in the case of lead poisoning. Lead causes an elevation in blood uric acid concentration (uric acidemia) and a decrease in uric acid excretion. | |||||||||
| NFPA 704 |
|
Uric acid price More Price(19)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | U2625 | Uric acid ≥99%, crystalline | 69-93-2 | 25G | ₹4600 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | U2625 | Uric acid ≥99%, crystalline | 69-93-2 | 100G | ₹13310 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | U2625 | Uric acid ≥99%, crystalline | 69-93-2 | 1KG | ₹50949 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | U0881 | Uric acid BioXtra, ≥99% (HPLC) | 69-93-2 | 10G | ₹5383.5 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | U0881 | Uric acid BioXtra, ≥99% (HPLC) | 69-93-2 | 25G | ₹6648.9 | 2022-06-14 | Buy |
Uric acid Chemical Properties,Uses,Production
Chemical Properties
Uric acid (C5H4O3N4) is a white solid that is insoluble in cold water, alcohol, or ether and sparingly soluble in hot water. It acts as a weak dibasic acid, creating two series of salts, with most being very slightly soluble in water (except for lithium urate, which is soluble).
Occurrence
Uric acid is found in the urine, blood, and muscle juices of carnivorous animals (herbivorous animals secrete hippuric acid), in the excrement of birds, serpents and insects, and is an oxidation product of the complex nitrogenous compounds of the animal organism.
Uses
Uric Acid is a heterocyclcic compound that is created when purine nucleotides are broken down of by the human body. High blood concetration of Uric Acid is known as hyperuricemia and is often associated with a wide range of disorders and medical conditions such as gout, diabetes and metabolic syndrome. Uric acid may be a marker of oxidative stress and may have a potential therapeutic role as an antioxidant.
Definition
A nitrogen compound produced from purines. In certain animals (e.g. birds and reptiles), it is the main excretory product resulting from breakdown of amino acids. In humans, uric acid crystals in the joints are the cause of gout.
Safety Profile
Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.
Purification Methods
Crystallise uric acid from hot distilled H2O (the solubility in H2O is 1part/39,000parts at 18o and 1part/2,000parts at 100o). It is best purified by dissolving in an alkaline solution and acidifying with dilute HCl and drying it at 100o in a vacuum. [Bergmann & Dikstein J Am Chem Soc 77 691 1955, Lister Purines Part II, Fused Pyrimidines Brown Ed, Wiley-Interscience pp256-257 1971, ISBN 0-471-38205-1, Beilstein 26 H 513, 26 I 151, 26 II 293, 26 III/IV 2619.]
References
Regulation of uric acid metabolism and excretion DOI:10.1002/RECL.19881071209
Purification of Laboratory Chemicals, Fourth Edition. By W. L. F. DOI:10.1002/RECL.19881071209
Van Nostrand’s Scientific Encyclopedia DOI:10.1007/978-1-4757-6918-0
The Facts on File Dictionary of Chemistry DOI:10.5860/choice.37-4227
A Dictionary of Chemistry (6th edition) DOI:10.1108/09504120910935291
Uric Acid in Inflammation and the Pathogenesis of Atherosclerosis DOI:10.3390/ijms222212394
Uric acid Preparation Products And Raw materials
Raw materials
Preparation Products
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| Supplier | Advantage |
|---|---|
| CHEMSWORTH | 30 |
| ALPHA CHEMIKA | 43 |
| Scientific OEM | 38 |
| CLEARSYNTH LABS LTD. | 58 |
| Maas Pharma Chemicals | 58 |
| A.J Chemicals | 58 |
| Otto Chemie Pvt. Ltd. | 58 |
| TCI Chemicals (India) Pvt. Ltd. | 58 |
| Sisco Research Laboratories Pvt. Ltd. | 58 |
| Alfa Aesar | 58 |
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