6-Hydroxypurine
- CAS No.
- 68-94-0
- Chemical Name:
- 6-Hydroxypurine
- Synonyms
- HYPOXANTHINE;9H-PURIN-6-OL;Hypoxanthine-d4;Hypoxanthine,99%;Hypoxanthine, 99.5%;3,7-dihydropurin-6-one;1,7-DIHYDRO-6H-PURIN-6-ONE;Azathioprine EP Impurity F;6H-Purin-6-one, 1,7-dihydro-;6H-Purin-6-one, 1,9-dihydro-
- CBNumber:
- CB5378579
- Molecular Formula:
- C5H4N4O
- Molecular Weight:
- 136.11
- MOL File:
- 68-94-0.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/6/13 17:03:25
| Melting point | >300 °C (lit.) |
|---|---|
| Boiling point | 250.36°C (rough estimate) |
| Density | 1.4295 (rough estimate) |
| refractive index | 1.8500 (estimate) |
| storage temp. | 2-8°C |
| solubility | 1 M NaOH: 25 mg/mL |
| form | powder |
| pka | 8.7(at 25℃) |
| color | Colorless to yellow to brown, darken on storage with no loss of purity |
| Odor | Odorless |
| Water Solubility | practically insoluble |
| Merck | 14,4869 |
| BRN | 5811 |
| InChIKey | FDGQSTZJBFJUBT-UHFFFAOYSA-N |
| LogP | -0.910 (est) |
| CAS DataBase Reference | 68-94-0(CAS DataBase Reference) |
| NIST Chemistry Reference | Hypoxanthine(68-94-0) |
| EPA Substance Registry System | Hypoxanthine (68-94-0) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264b-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P330-P362+P364-P403+P233-P501c | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 36/37/38-22-40 | |||||||||
| Safety Statements | 22-24/25-37/39-26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | UP0791000 | |||||||||
| Hazard Note | Harmful | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29335990 | |||||||||
| Toxicity | LD50 intraperitoneal in mouse: 750mg/kg | |||||||||
| NFPA 704 |
|
6-Hydroxypurine price More Price(19)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | H9636 | Hypoxanthine powder, BioReagent, suitable for cell culture | 68-94-0 | 1G | ₹2652.13 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | H9636 | Hypoxanthine powder, BioReagent, suitable for cell culture | 68-94-0 | 5G | ₹4611.45 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | H9636 | Hypoxanthine powder, BioReagent, suitable for cell culture | 68-94-0 | 25G | ₹12914.23 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | H9377 | Hypoxanthine ≥99.0% | 68-94-0 | 5G | ₹2024.28 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | H9377 | Hypoxanthine ≥99.0% | 68-94-0 | 25G | ₹5380.03 | 2022-06-14 | Buy |
6-Hydroxypurine Chemical Properties,Uses,Production
Description
Hypoxanthine is a naturally occurring purine derivative and intermediate in the synthesis of uric acid. It is elevated in the spinal fluid of patients with Lesch-Nyhan syndrome, a metabolic disorder whose symptoms include cerebral palsy, cognitive deficits, motor dysfunction, self-mutilation, and hyperuricemia. Injection of hypoxanthine (10 μM) increases succinate dehydrogenase and complex II activities and decreases cytochrome c oxidase activity, resulting in neuroenergetic impairment, ATP depletion, and cellular apoptosis in rat striatum. It is also used to induce hyperuricemia in mice for use in the development of hypouricemic agents.
Chemical Properties
White to off-white powder
Uses
A naturally occurring purine derivative. Pharmaceuticals, Intermediates & Fine Chemicals
Definition
ChEBI: A purine nucleobase that consists of purine bearing an oxo substituent at position 6.
General Description
Hypoxanthine (6-hydroxypurine), a purine derivative is a naturally occurring compound. It is the deaminated form of adenine and a breakdown product of adenosine monophosphate (AMP).
Safety Profile
Moderately toxic by intraperitoneal route. An experimental teratogen. When heated to decomposition it emits toxic fumes of Nox
Purification Methods
Crystallise it from hot water and dry it at 105o. [Beilstein 26 II 252, 26 III/IV 2081.]
6-Hydroxypurine Preparation Products And Raw materials
Raw materials
Preparation Products
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| Supplier | Advantage |
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| GLR Innovations | 58 |
| OPULENT PHARMA | 58 |
| Otto Chemie Pvt Ltd | 58 |
| Vijaya Pharma And Life Science | 58 |
| Scientific OEM | 38 |
| S.R.LABORATORIES | 30 |
| Sisco Resech Laboratories Private Limited | 58 |
| Maas Pharma Chemicals | 58 |
| Loba Chemie Pvt Ltd | 58 |
| CHEMSWORTH | 30 |
68-94-0(6-Hydroxypurine)Related Search:
6-Mercaptopurine disulfide
GUANERAN
Ethanone, 1-[6-[(1-methyl-4-nitro-1H-imidazol-5-yl)thio]-9H-purin-9-yl]-
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1H-Imidazol-5-amine,1-methyl-4-nitro-(9CI)
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HYPOXANTHINE ANHYDROUS
Hypoxanthinee
HYPOXANTHINE(RG)
6-HYDROXYPURINE(HYPOXANTHINE)
purine-6(1H)-one
Hypexanthine
6-oxypurine
HYPOXANTHINE extrapure
HYPOXANTHINE (Hyp)
Didanosine Related CoMpound A
Didanosine Related Compound A (25 mg) (Hypoxanthine)
Hypoxanthine, 99.5% 25GR
Hypoxanthine, 99.5% 5GR
1,9-Dihydro-
Hypoxanthine API
Hypoxanthine ,98%
6(1H)-PURINONE
HYPOXANTHINE CELL CULTURE TESTED
HYPOXANTHINE 99%
HypoxanthineForBiochemistry
HypoxanthineForBiochemistry99%
HYPOXANTHINE FOR BIOCHEMISTRY 99%
6H-Purin-6-one, 1,7-dihydro- (9CI)
1,7-dihydro-6h-purin-6-on
1,7-Dihydro-6H-purine-6-one
AKOS BBS-00002144
3H-Purin-6-ol
4-Hydroxy-1H-purine
6-Hydropurine
6-Hydroxy-1H-purine
6-Oxopurine
7H-Purin-6-ol
9H-Purin-6(1H)-one
1H-Purin-6(9H)-one
Hypoxanthine Vetec(TM) reagent grade, 98%
1H-Purin-6(7H)-one
Hypoxanthine, Animal-Free
Hypoxsanthine (1,7-Dihydro-6H-purin-6-one)
hypoxanthineenol
Hypoxathine
Purin-6(3H)-one
Purine-6-ol
Sarkine
Purin-6(1H)-one
PURIN-6-OL
SARCINE
SARKIN
TTGGTTGGGTGGTHGGTGTTGGGG
TIMTEC-BB SBB004203
IFLAB-BB F1386-0269
LABOTEST-BB LT00440805
6-HYDROXYPURINE
Mercaptopurine EP Impurity A
Didanosin Related Compound A
Didanosine Impurity 1（Didanosine EP Impurity A）
Mercaptopurine Impurity 1（Mercaptopurine EP Impurity A）
Hypoxanthine - CAS 68-94-0 - Calbiochem
Didanosine Impurity Ⅰ:6-Hydroxypurine