ChemicalBook > Product Catalog >API >Antineoplastic agents >Antimetabolites, Antineoplastic >6-Mercaptopurine
6-Mercaptopurine
- CAS No.
- 50-44-2
- Chemical Name:
- 6-Mercaptopurine
- Synonyms
- 6mp;THIOPURINE;mercaptopurin;purinethol;7H-PURINE-6-THIOL;Azathioprine EP Impurity B;3,7-dihydro-6H-purine-6-thione;mern;nsc755;u-4748
- CBNumber:
- CB1425059
- Molecular Formula:
- C5H4N4S
- Molecular Weight:
- 152.18
- MOL File:
- 50-44-2.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/2 8:55:00
| Melting point | 241-244°C |
|---|---|
| Boiling point | 498.6±37.0 °C(Predicted) |
| Density | 1.463 (estimate) |
| refractive index | 1.5605 (estimate) |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | DMSO : 35.71 mg/mL (234.66 mM; Need ultrasonic) |
| form | solid |
| pka | 7.77, 11.17(at 25℃) |
| color | Light yellow to yellow |
| Water Solubility | 124mg/L(25 ºC) |
| CAS DataBase Reference | 50-44-2(CAS DataBase Reference) |
| IARC | 3 (Vol. 26, Sup 7) 1987 |
| EPA Substance Registry System | Mercaptopurine (50-44-2) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
| RIDADR | 3249 |
| HazardClass | 6.1(b) |
| PackingGroup | III |
| HS Code | 2933599590 |
| Toxicity | LD50 oral in rat: 277mg/kg |
6-Mercaptopurine Chemical Properties,Uses,Production
Chemical Properties
Yellowish-Greenish Solid
Uses
Has a cytotoxicity effect
Uses
6-Mercaptopurine (6-MP) is a antineoplastic, immonusupressant; inhibits purine nucleotide synthesis and metabolism. 6-MP have been used for several decades in the treatment of leukemia and certain other neoplastic diseases. 6-Mercaptopurine is used for maintenance therapy of acute lymphocytic and acute myelogenous leukemia.
Definition
A sulfurcontaining purine base not found in animal nucleoproteins.
Hazard
Questionable carcinogen.
Safety Profile
Poison by ingestion, intraperitoneal, subcutaneous, parenteral, and intravenous routes. Human systemic effects by ingestion: dermatitis. Experimental teratogenic and reproductive effects. Questionable human carcinogen producing Hodgkin's disease and leukemia. Human mutation data reported. When heated to decomposition it emits very toxic fumes of SOx and NOx. See also MERCAPTANS.
6-Mercaptopurine Preparation Products And Raw materials
Raw materials
chevron_left
1of3
chevron_rightPreparation Products
Global( 331)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Aarti Industries Limited (AIL) | +91-84596144931 +91-9920899935 | Maharashtra, India | 235 | 58 | Inquiry |
| Surajlok Chemicals Pvt Ltd (Neon Laboratories Ltd) | +91-2268107000 +91-9987232509 | Maharashtra, India | 30 | 58 | Inquiry |
| M M Kemicals | +91-7032683572 +91-9989927761 | Telangana, India | 38 | 58 | Inquiry |
| Erevna Pharma Private Limited | +91-9962143988 +91-9884394900 | Telangana, India | 46 | 58 | Inquiry |
| Godavari Drugs Limited | +91-9573282211 +91-9325610564 | Maharashtra, India | 8 | 58 | Inquiry |
| Clickchem Research LLP | +91-8140031133 +91-8140031133 | Gujarat, India | 411 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| Manus Aktteva | +91 (79) 6512-3395 | New Delhi, India | 581 | 34 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
Related articles
- 6-Mercaptopurine: Mechanism of Action and Mechanism of Resistance
- 6-Mercaptopurine has been used as an antineoplastic and immunosuppressive agent for decades, but the precise mechanism by whic....
- Mar 28，2024
50-44-2(6-Mercaptopurine )Related Search:
chevron_left
1of4
chevron_right
mercaptopurine，6-MP
mercapurin
merkaptopuryna
mern
nci-c04886
nsc755
purimethol
MERCAPTOPURINE MONOHYDRATE, 6-(RG)
1,9-Dihydropurine-6-thioneDISCONTINUED, see M225450
6-THIOPURINE 99%
mercaptop
Ismipurine
6-Mercaptopurine-13C1-15N2
1H-Purine-6(9H)-thione
3,7-Dihydro-6H-purine-6-thione, 6-Thiopurine, 6-Thiohypoxanthine, Purine-6-thiol
3H-purine-6(7H)-thione
LEUKERIN
1,7-Dihydro-6H-purine-6-thione
7-mercapto-1,3,4,6-tetrazaindene
6-MERCAPTOPURINE
6-PURINETHIOL
3h-purine-6-thiol
PURINE-6-THIOL
1,7-dihydro-6h-purine-6-thion
6-mercaptopurin
6-mercapto-purin
6-merkaptopurin
6-THIOPURINE
6-thioxopurine
6-THIOHYPOXANTHINE
ismipur
leupurin
mercaleukin
mercapto-6purine
purinethiol
thio-hypoxanthin
u-4748
Mercaptopurine USP
6-Mercaptopurine,>99%
1,9-Dihydropurine-6-thione
6-MP;MERCAPTOPURINE
1H-Purine-6(7H)-thione
6H-Purine-6-thione, 1,9-dihydro-
mere apt opurine
6-Mercaptopurine USP/EP/BP
MercaptopurineQ: What is
Mercaptopurine Q: What is the CAS Number of
Mercaptopurine Q: What is the storage condition of
Mercaptopurine
THIOPURINE
mercaptopurin
7H-PURINE-6-THIOL
6mp
purinethol
Azathioprine EP Impurity B
3,7-dihydro-6H-purine-6-thione
PURINE-6(1H)-THIONE
Isoxaben Impurity 38
6-Mercaptopurine (Azathioprine EP Impurity B)
9H-purine-6-thiol
50-44-2