Xanthine
- CAS No.
- 69-89-6
- Chemical Name:
- Xanthine
- Synonyms
- XANTHINE;Xan;Xanthin;ISOXANTHINE;3,7-Dihydro-1H-purine-2,6-dione;7H-xanthine;9H-PURINE-2,6-DIOL;1H-Purine-2,6(3H,7H)-dione;Xanthione;usafcb-17
- CBNumber:
- CB0197999
- Molecular Formula:
- C5H4N4O2
- Molecular Weight:
- 152.11
- MOL File:
- 69-89-6.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/5/23 13:57:25
| Melting point | 300 °C |
|---|---|
| Boiling point | 274.55°C (rough estimate) |
| Density | 1.5452 (rough estimate) |
| vapor density | 5.3 (vs air) |
| refractive index | 1.8500 (estimate) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | NH4OH: freely soluble |
| form | Powder |
| pka | pKa 9.95 (Uncertain) |
| color | White to slightly yellow |
| Odor | Odorless |
| Water Solubility | Soluble in water(0.067g/L). |
| Merck | 14,10059 |
| BRN | 8733 |
| InChIKey | LRFVTYWOQMYALW-UHFFFAOYSA-N |
| LogP | -0.730 |
| CAS DataBase Reference | 69-89-6(CAS DataBase Reference) |
| NIST Chemistry Reference | Xanthine(69-89-6) |
| EPA Substance Registry System | Xanthine (69-89-6) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H317-H319 | |||||||||
| Precautionary statements | P280-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36-43-36/37/38 | |||||||||
| Safety Statements | 36/37-37/39-26 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | ZD7700000 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29335990 | |||||||||
| NFPA 704 |
|
Xanthine price More Price(19)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | X7375 | Xanthine ≥99% | 69-89-6 | 10G | ₹6748.8 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | X7375 | Xanthine ≥99% | 69-89-6 | 25G | ₹14840.7 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | X7375 | Xanthine ≥99% | 69-89-6 | 100G | ₹40759.2 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | X4002 | Xanthine BioUltra, ≥99% | 69-89-6 | 1G | ₹8003.1 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | X4002 | Xanthine BioUltra, ≥99% | 69-89-6 | 5G | ₹15573.3 | 2022-06-14 | Buy |
Xanthine Chemical Properties,Uses,Production
Chemical Properties
White to off-white crystalline powder
Uses
2,6-Dihydroxypurine was fund in animal organs, yeast, patatoes, coffee beans, tea. 2,6-Dihydroxypurine can be used to relax and widen certain breathing passages of the lungs. It is also found that a large number of derivatives have adenoside receptor antagonist properties.
Definition
A poisonous colorless crystalline organic compound that occurs in blood, coffee beans, potatoes, and urine. It is used as a chemical intermediate.
Origin
Xanthines (1H-purine-2,6(3H,7H)-diones) are purine based natural heterocyclic alkaloids. They were first discovered in 1817 by German chemist Emil Fisher and later the name ‘xanthine’ was coined in 1899[1].
Biological Functions
In fact, xanthine and its derivatives act as intermediate molecules in generation of GMP, GDP and GTP via the salvage pathway inside the cells. In addition, xanthine plays imperative role in catabolism of nucleotides and nucleic acids as xanthine acts as precursor of uric acid. Therefore, xanthine contains similar skeleton as that of purines which forms the building blocks of unit of life i.e. ribonucleotides (RNA) and deoxyribonucleotides (DNA). The structural resemblance with two of the important purine derivatives Adenine and Guanine; makes xanthine a good therapeutic molecule[1].
General Description
Xanthine is a purine that can be produced in the purine metabolic pathway via different precursors:
- Guanine deamination by guanine deaminase
- Hypoxanthine conversion by xanthine oxidoreductase
Purification Methods
The monohydrate separates in a microcrystalline form on slow acidification with acetic acid of a solution of xanthine in dilute NaOH. It is also precipitated by addition of conc NH3 to its solution in hot 2N HCl (charcoal). After washing with H2O and EtOH, it is dehydrated by heating above 125o. Its solubility in H2O is 1 in 14,000parts at 16o and 1 in 1,500parts of boiling H2O, and separates as plates . It has no m, but the perchlorate has m 262-264o [Lister Purines Part II, Fused Pyrimidines Brown Ed, Wiley-Interscience pp252-253 1971, ISBN 0-471-38205-1]. [Beilstein 26 H 447, 26 I 131, 26 II 260, 26 III/IV 2327.]
References
[1] Ahlawat, Jyoti Minakshi Sharma and Chandra S. Pundir. “Advances in xanthine biosensors and sensors: A review.” Enzyme and Microbial Technology 69 1 (2023).
Xanthine Preparation Products And Raw materials
Raw materials
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|---|---|---|---|---|---|
| CHEMSWORTH | +91-261-2397244 | New Delhi, India | 6707 | 30 | Inquiry |
| Scientific OEM | +91-22- 2343 7546 / 2341 3094 | New Delhi, India | 1996 | 38 | Inquiry |
| ALPHA CHEMIKA | +91-22-22061123 +91-22-66382501 | Mumbai, India | 1681 | 43 | Inquiry |
| Trignokem International | +91 (40) 2717-0709 | New Delhi, India | 380 | 50 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Triveni chemicals | 08048762458 | New Delhi, India | 6093 | 58 | Inquiry |
| Central Drug House(P) Ltd. | 91-11-49404040 | New Delhi, India | 6160 | 58 | Inquiry |
| LOBA CHEMIE PVT.LTD. | 91-22-6663 6699 | Mumbai, India | 3077 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| CHEMSWORTH | 30 |
| Scientific OEM | 38 |
| ALPHA CHEMIKA | 43 |
| Trignokem International | 50 |
| CLEARSYNTH LABS LTD. | 58 |
| A.J Chemicals | 58 |
| Pharmaffiliates Analytics and Synthetics P. Ltd | 58 |
| Triveni chemicals | 58 |
| Central Drug House(P) Ltd. | 58 |
| LOBA CHEMIE PVT.LTD. | 58 |
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