Aminophylline
- CAS No.
- 317-34-0
- Chemical Name:
- Aminophylline
- Synonyms
- aminophyllin;ethophylline;THEOPHYLLINE ETHYLENEDIAMINE;theomin;euufilin;grifomin;miofilin;theodrox;theolone;cardiomin
- CBNumber:
- CB8145350
- Molecular Formula:
- C9H16N6O2
- Molecular Weight:
- 240.27
- MOL File:
- 317-34-0.mol
- Modify Date:
- 2024/4/25 17:59:01
| Melting point | 269-270 °C |
|---|---|
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
| solubility | H2O: 3.7 mg/mL solutions should be freshly prepared. |
| form | powder |
| pka | pKa 5.0 (Uncertain) |
| color | white to off-white |
| Water Solubility | soluble |
| Merck | 14,465 |
| InChI | InChI=1S/C7H8N4O2.C2H8N2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13;3-1-2-4/h3H,1-2H3,(H,8,9);1-4H2 |
| InChIKey | LHRHXWBJUQKYEL-UHFFFAOYSA-N |
| SMILES | O=C1N(C(=O)N(C)C2NC=NC1=2)C.C(N)CN |
| LogP | -0.175 (est) |
| CAS DataBase Reference | 317-34-0(CAS DataBase Reference) |
| EPA Substance Registry System | 1H-Purine-2,6-dione, 3,7-dihydro-1,3-dimethyl-, compd. with 1,2-ethanediamine (2:1) (317-34-0) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301 | |||||||||
| Precautionary statements | P301+P310 | |||||||||
| Hazard Codes | Xn,C | |||||||||
| Risk Statements | 22-42/43-34-36/37/38-20/21/22 | |||||||||
| Safety Statements | 45-36/37/39-26-23-36 | |||||||||
| RIDADR | UN 2811 6.1/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | XH5600000 | |||||||||
| F | 10-23 | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29339900 | |||||||||
| Toxicity | LD50 orally in mice: 540 mg/kg (Thompson, Warren) | |||||||||
| NFPA 704 |
|
Aminophylline Chemical Properties,Uses,Production
Description
Aminophylline is a 2/1 mixture of theophylline and ethylenediamine. It caused contact dermatitis in industrial plants, in pharmacists, and in nurses. Ethylenediamine is the sensitizer, and patch testing is generally positive to both ethylenediamine and aminophylline, but negative to theophylline.
Chemical Properties
white to slightly yellowish powder
Uses
Aminophylline is a bronchodilator and a non-selective phosphodiesterase (PDE) inhibitor.
World Health Organization (WHO)
Aminophylline, the ethylenediamine salt of theophylline, was introduced many years ago as a treatment for asthma and is listed in the 8th WHO Model List of Essential Drugs. It has been recognized for some 10 years that aminophylline preparations are not interchangeable because bioavailability can vary considerably. The resulting variability in drug absorption can lead to adverse effects including irritation of the mucosa. Allergic reation can also be an adverse effect of aminophylline. Theophylline functions similarly but is considered less of an irritant.
Hazard
Cardiovascular and respiratory collapse.
Contact allergens
This drug is a 2:1 mixture of the alkaloid theophylline and ethylenediamine (see below). It caused contact dermatitis in industrial plants, pharmacists, and nurses. Ethylenediamine is the sensitizer and patch testing is generally positive to both ethylenediamine and aminophylline and negative to theophylline.
Aminophylline Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Aarti Industries Limited (AIL) | +91-84596144931 +91-9920899935 | Maharashtra, India | 235 | 58 | Inquiry |
| Bajaj Healthcare Ltd | +91-2266177400 +91-2266177400 | Maharashtra, India | 86 | 58 | Inquiry |
| S S Pharmachem | +91-9324209894 +91-9702111022 | Maharashtra, India | 20 | 58 | Inquiry |
| Bakul Pharma Private Limited | +91-2261697900 +91-2261697900 | Maharashtra, India | 66 | 58 | Inquiry |
| KPS Chemicals And Pharmaceuticals | +91-9870076629 +91-8469484608 | Gujarat, India | 33 | 58 | Inquiry |
| AKASH PHARMA EXPORTS | +91-9388123451 +91-9846039283 | Kerela, India | 470 | 58 | Inquiry |
| OCEAN TRADING CORPORATION | +91(22) 24921669 | New Delhi, India | 6211 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Aquatic Remedies Private Limited | 09819801980 | Mumbai, India | 4 | 58 | Inquiry |