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ChemicalBook > Product Catalog >Organic Chemistry >Amides >Acyclic polyamines and their derivatives >N,N,N',N'-Tetramethylethylenediamine

N,N,N',N'-Tetramethylethylenediamine

N,N,N',N'-Tetramethylethylenediamine Structure
CAS No.
110-18-9
Chemical Name:
N,N,N',N'-Tetramethylethylenediamine
Synonyms
TMEDA;TEMED;TETRAMETHYLETHYLENEDIAMINE;N1,N1,N2,N2-tetraMethylethane-1,2-diaMine;TMED;1,4-DIAMINOBUTANE;TD;1,2-BIS(DIMETHYLAMINO)ETHANE;2,5-DiMethyl-2,5-diazahexane;N,N,N',N'-TETRAMETHYLENEDIAMINE
CBNumber:
CB2446761
Molecular Formula:
C6H16N2
Molecular Weight:
116.2
MOL File:
110-18-9.mol
Modify Date:
2024/8/6 16:32:36
Request For Quotation

N,N,N',N'-Tetramethylethylenediamine Properties

Melting point −55 °C(lit.)
Boiling point 120-122 °C(lit.)
Density 0.775 g/mL at 20 °C(lit.)
vapor density 4 (vs air)
vapor pressure 21 hPa (20 °C)
refractive index n20/D 1.4179(lit.)
Flash point 50 °F
storage temp. Store below +30°C.
solubility H2O: 10 mg/mL at 20 °C, clear, colorless
form Liquid
pka 10.40, 8.26(at 25℃)
Specific Gravity 0.777 (20/4℃)
color Clear colorless to slightly yellow
PH 8.0-8.5 (0.1g/l, H2O, 20℃)
Odor Amine like
explosive limit 1-9%(V)
Water Solubility miscible
Sensitive Hygroscopic
Merck 14,9134
BRN 1732991
Stability Stable. Highly flammable. Incompatible with strong oxidizing agents, acids, acid chlorides, acid anhydrides, copper, mercury.
InChIKey DMQSHEKGGUOYJS-UHFFFAOYSA-N
LogP -0.13 at 20.2℃
CAS DataBase Reference 110-18-9(CAS DataBase Reference)
NIST Chemistry Reference 1,2-Ethanediamine, N,N,N',N'-tetramethyl-(110-18-9)
EPA Substance Registry System Tetramethylethylenediamine (110-18-9)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS02,GHS05,GHS06
Signal word  Danger
Hazard statements  H225-H301+H331-H314
Precautionary statements  P210-P233-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338
Hazard Codes  F,C,Xi
Risk Statements  11-20/22-34-20/21/22
Safety Statements  16-26-36/37/39-45
RIDADR  UN 2372 3/PG 2
WGK Germany  1
RTECS  KV7175000
F  3-8-10-34
Autoignition Temperature 145 °C
Hazard Note  Irritant
TSCA  Yes
HazardClass  3
PackingGroup  II
HS Code  29212900
NFPA 704
3
3 0

N,N,N',N'-Tetramethylethylenediamine price More Price(34)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) T9281 N,N,N′,N′-Tetramethylethylenediamine BioReagent, suitable for electrophoresis, ~99% 110-18-9 25ML ₹5315.08 2022-06-14 Buy
Sigma-Aldrich(India) T9281 N,N,N′,N′-Tetramethylethylenediamine BioReagent, suitable for electrophoresis, ~99% 110-18-9 100ML ₹6343.45 2022-06-14 Buy
Sigma-Aldrich(India) T9281 N,N,N′,N′-Tetramethylethylenediamine BioReagent, suitable for electrophoresis, ~99% 110-18-9 50ML ₹9233.73 2022-06-14 Buy
Sigma-Aldrich(India) T7024 N,N,N′,N′-Tetramethylethylenediamine BioReagent, for molecular biology, ≥99% (GC) 110-18-9 100ML ₹5315.08 2022-06-14 Buy
Sigma-Aldrich(India) T7024 N,N,N′,N′-Tetramethylethylenediamine BioReagent, for molecular biology, ≥99% (GC) 110-18-9 25ML ₹5921.28 2022-06-14 Buy
Product number Packaging Price Buy
T9281 25ML ₹5315.08 Buy
T9281 100ML ₹6343.45 Buy
T9281 50ML ₹9233.73 Buy
T7024 100ML ₹5315.08 Buy
T7024 25ML ₹5921.28 Buy

N,N,N',N'-Tetramethylethylenediamine Chemical Properties,Uses,Production

Chemical Properties

Colorless to slightly yellow liquid

Uses

N,N,N',N'-Tetramethylethylenediamine is used as polymerization accelerator in gel electrophoresis, solvent and oxidizing reagent. It is also used for the separation of proteins or nucleic acids. Further, it is employed as a ligand for metal ions like zinc and copper. It is actively involved in the formation of anionic organometallic complex.

Definition

ChEBI: N,N,N',N'-tetramethylethylenediamine is an ethylenediamine derivative in which each nitrogen carries two methyl substituents. It is widely employed both as a ligand for metal ions and as a catalyst in organic polymerisation. It has a role as a chelator and a catalyst.

General Description

1,2-di-(dimethylamino)ethane appears as a water-white colored liquid with a fishlike odor. Flash point 68 °F. Less dense than water. Vapors heavier than air. Used to make other chemicals.

Air & Water Reactions

Highly flammable. Slightly soluble in water. Sensitive to heat and may be sensitive to air .

Reactivity Profile

N,N,N',N'-Tetramethylethylenediamine neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

Health Hazard

May cause toxic effects if inhaled or absorbed through skin. Inhalation or contact with material may irritate or burn skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.

Fire Hazard

HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.

Safety Profile

Moderately toxic by ingestion. Mddly toxic by slun contact. A skin and severe eye irritant. Flammable when exposed to heat or flame; can react with oxidizing materials. When heated to decomposition it emits toxic fumes of NOx. See also MINES.

Purification Methods

Dry TMEDA partially with molecular sieves (Linde type 4A), then distil it in a vacuum from butyl lithium. This treatment removes all traces of primary and secondary amines and water. [Hay et al. J Chem Soc, Faraday Trans 1 68 1 1972.] Or dry it with KOH pellets, reflux for 2hours with one-sixth its weight of n-butyric anhydride (to remove primary and secondary amines) and fractionally distil it. Reflux it with fresh KOH, and distil it under nitrogen. [Cram & Wilson J Am Chem Soc 85 1245 1963.] It was also distilled from Na. Store it sealed under N2. The dipicrate has m 263o(dec). [Beilstein 4 H 250, 4 I 415, 4 II 690, 4 III 512, 4 IV 1172.]

N,N,N',N'-Tetramethylethylenediamine Preparation Products And Raw materials

Raw materials

Oxalic acid dihydrate Ethylenediamine Formaldehyde Formic acid Paraformaldehyde

Preparation Products

4,5-Bis(diphenylphosphino)-9,9-dimethylxanthene 2,3-DIHYDROBENZOFURAN-7-CARBOXYLIC ACID 1,1'-Bis (di-t-butylphosphino)ferrocene palladium dichloride, 2-(TRIFLUOROMETHOXY)BENZAMIDE 1,1'-FERROCENEDICARBOXALDEHYDE
1 1'-BIS(DIPHENYLPHOSPHINO)FERROCENE 5-ETHYL-2-FURALDEHYDE 5-AMINO-2-METHOXY-ISONICOTINIC ACID 3-METHYLBENZO[B]THIOPHENE 1,1'-Bis(diphenylphosphino)ferrocene
5-[(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOROISONICOTINIC ACID (OXYDI-2,1-PHENYLENE)BIS(DIPHENYLPHOSPHINE) 1,1'-Bis(di-tert-butylphosphino)ferrocene 2-ACETYL-3-METHYLBENZO[B]THIOPHENE 2-MORPHOLINO-5-(TRIFLUOROMETHYL)BENZALDEHYDE
N-(4-FORMYL-PYRIDIN-3-YL)-2,2-DIMETHYL-PROPIONAMIDE 5-ACETYL-2-THIOPHENECARBALDEHYDE 2,3-Dimethoxyphenylboronic acid 1,1'-DIMETHYLFERROCENE 1-DIPHENYLPHOSPHINO-1'-(DI-TERT-BUTYLPH&
5-AMINO-2-CHLOROPYRIDINE-4-CARBOXYLIC ACID 1,1'-Bis(diisopropylphosphino)ferrocene 4,6-DIMETHYLDIBENZOTHIOPHENE 5-(METHYLTHIO)THIOPHENE-2-CARBOXYLIC ACID 3-METHYLBENZO[B]THIOPHENE-2-CARBOXALDEHYDE
5-AMINO-2-FLUORO-ISONICOTINIC ACID
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N,N,N',N'-Tetramethylethylenediamine Suppliers

Global( 584)Suppliers
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Tulasi Labs +91-8106722317 +91-8106722317 Telangana, India 44 58 Inquiry
Raising Sun Pharma +91-9399941155 +91-9399941155 Telangana, India 127 58 Inquiry
JSK Chemicals +919879767970 Gujarat, India 3756 58 Inquiry
Maas Pharma Chemicals +91-9958666224 Delhi, India 1607 58 Inquiry
Spectrochem Private Limited 08048372608Ext 246 Maharashtra, India 1056 58 Inquiry
VASIN BIO LIFE SCIENCES PVT LTD 9491644688 Hyderabad, India 2096 58 Inquiry
Molychem 08048372666Ext 559 Mumbai, India 577 58 Inquiry
Dr Prem's Molecules Pvt. Ltd. +91 9825310038 New Delhi, India 547 50 Inquiry
S. Nihar Exports 91 22 208 5632 New Delhi, India 232 50 Inquiry
ALPHA CHEMIKA +91-22-22061123 +91-22-66382501 Mumbai, India 1681 43 Inquiry
Supplier Advantage
Tulasi Labs 58
Raising Sun Pharma 58
JSK Chemicals 58
Maas Pharma Chemicals 58
Spectrochem Private Limited 58
VASIN BIO LIFE SCIENCES PVT LTD 58
Molychem 58
Dr Prem's Molecules Pvt. Ltd. 50
S. Nihar Exports 50
ALPHA CHEMIKA 43

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N,N,N',N'-Tetramethylethane-1,2-diamine, electrophoresis grade Four MethylEthylenediaMine N,N,N',N'-TetraMethylethylenediaMine >=99.5%, purified by redistillation N,N,N',N'-TetraMethylethylenediaMine ReagentPlus(R), 99% (CH3)2NCH2CH2N(CH3)2 1,2-Diaminoethane, N,N,N',N'-tetramethyl- 1,2-Ethanediamine,N,N,N’,N’-tetramethyl- 2-Ethanediamine,N,N,N’,N’-tetramethyl-1 dimethyl(2-(dimethylamino)ethyl)amine Dimethyl[2-(dimethylamino)ethyl]amine Ethylenediamine, N,N,N',N'-tetramethyl- N,N,N',N'-Tetramethyl-1,2-ethanediamine N,N,N',N'-Tetramethylethanediamine N,N,N',N'-Tetramethylethenediamine N,N,N’,N’-Tetramethyl-1,2-ethanediamine n,n,n’,n’-tetramethyl-2-ethanediamine N,N,N’,N’-Tetramethyl-ethane-1,2-diamine 1,2-Bis(dimethylamino)ethane~TEMED~TMEDA N,N,N,N-TetramethylAV12537 NNNN-Tetramethyl-ethylenediamine 99+ % (GLC) temed electrophoresis TEMED, Molecular Biology Grade N,N,N,N-Tetramethylethylenediamine, Molecular Biology Grade CN,N,N',N'-Tetramethylethylenediamine N,N,N',N'-TETRAMETHYLETHYLENEDIAMINE, AB SOLUTE N,N,N',N'-TETRAMETHYLETHYLENEDIAMINE, RE DISTILLED, 99.5+% TEMED MOLECULAR BIOLOGY REAGENT N,N,N',N'-TETRAMETHYLETHYLENEDIAMINE, FO R MOL. BIOLOGY N,N,N',N'-TETRAMETHYLETHYLENEDIAMINE, FO R ELECTROPHORESIS TEMED ELECTROPHORESIS REAGENT N,N,N',N'-TETRAMETHYLETHYLENEDIAMINE, REAGENTPLUS, 99% N N N' N'-TETRAMETHYLETHYLENEDIAMINE R& N,N,N',N'-Tetramethylethylenediamine>99% 1,2-did(dimethylamino)ethane N,N,N',N'-Tetramethylethylenediamine, extra pure, 99% N,N,N',N'-Tetramethylethylenediamine, For electrophoresis, for biochemistry, 99% N,N,N',N'-Tetramethylethylenediamine,99%TMEDA TEMED (N,N,N'',N''-TETRAMETHYLETHYLENDIAMINE) N,N,N′,N′-Tetramethylethylendiamin N,N,N',N'-TETRAMETHYL ETHYLENEDIAMINE pure N,N,N',N'-Tetramethylethylenediamine, 99%, extra pure Temed(N,N,NTetramethylethyleneDiamene) N,N,N',N'-Tetramethylethylenediamine,99%,forbiochemistry,For electrophoresis N,N,N',N'-Tetramethylethylenediamine Vetec(TM) reagent grade, >=99% AZINPHOS METHYL NEAT N,N,N′,N′-Tetramethylethylenediamine(TEMED、TMEDA) N,N,N'',N''-TETRAMETHYLETHYLENEDIAMI N,N,N1,N1-Tetramethylethylenediamine n,n,ni,ni-tetramethylethylenediamine Propamine D propamined Tetrameen Tetramethyldiaminoethane BIS(DIMETHYLAMINO)ETHANE 1,2-DI(DIMETHYLAMINO)ETHANE ,N,N',N'-Tetramethylethylenediamine N,N,N'N'-TETRAMETHYETHYLENEDIAMINE NNN'N'-TETRAMETHYL-1,2-DIAMINOETHANE NNN'N-TETRAMETHYL-1,2-DIAMINOETHANE