Diprophylline
- CAS No.
- 479-18-5
- Chemical Name:
- Diprophylline
- Synonyms
- DYPHYLLINE;DIPHYLLIN;Coronarin;Dihydroxypropyl;Dilor;Teofen;Circain;Neotilina;Neutrafil;Corphyllin
- CBNumber:
- CB7177891
- Molecular Formula:
- C10H14N4O4
- Molecular Weight:
- 254.24
- MOL File:
- 479-18-5.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/5/21 21:51:03
| Melting point | 161-162 °C(lit.) |
|---|---|
| Boiling point | 397.46°C (rough estimate) |
| Density | 1.3036 (rough estimate) |
| refractive index | 1.6200 (estimate) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | Freely soluble in water, slightly soluble in ethanol (96 per cent). |
| form | Powder |
| pka | 13.74±0.20(Predicted) |
| color | White |
| Water Solubility | 33 g/100 mL (25 ºC) |
| Merck | 14,3479 |
| BRN | 284563 |
| Stability | Hygroscopic |
| LogP | -1.100 (est) |
| CAS DataBase Reference | 479-18-5(CAS DataBase Reference) |
| NIST Chemistry Reference | Dyphylline(479-18-5) |
| EPA Substance Registry System | Dyphylline (479-18-5) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P301+P312+P330 | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 36-36/37-26 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | XH5100000 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29395900 | |||||||||
| Toxicity | LD50 in mice (mg/kg): 3400 orally; 1430 s.c. (Al'tshuler) | |||||||||
| NFPA 704 |
|
Diprophylline Chemical Properties,Uses,Production
Description
Dyphylline is the N-7 dihydroxypropyl derivative of theophylline and is not a theophylline salt. Dyphylline does not get metabolized to theophylline in vivo, and even though it contains 70% theophylline by molecular weight ratio, the equivalent amount to theophylline is not known. Dosing must be accomplished independently by monitoring dyphylline blood levels. Dyphylline has a diminished bronchodilator effect compared to theophylline, but it may have lower and less serious side effects. Dosage forms available are an elixir and tablets.
Chemical Properties
white to light yellow crystal powder
Uses
PDE inhibitor, bronchodilator, vasodilator
Definition
ChEBI: An oxopurine that is theophylline bearing a 2,3-dihydroxypropyl group at the 7 position. It has broncho- and vasodilator properties, and is used in the treatment of asthma, cardiac dyspnea, and bronchitis. It is also an ingredient in preparations that have been promoted for coughs.
Diprophylline Preparation Products And Raw materials
Raw materials
1of2
chevron_rightPreparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| HRV Global Life Sciences | +91-9820219686 +91-9820219686 | Telangana, India | 379 | 58 | Inquiry |
| Bakul Pharma Private Limited | +91-2261697900 +91-2261697900 | Maharashtra, India | 66 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Swapnroop Drugs & Pharmaceuticals | 08048371984Ext 910 | Maharashtra, India | 20 | 58 | Inquiry |
| Triveni Interchem Private Limited (Group Of Triveni... | 08046042087 | Gujarat, India | 497 | 58 | Inquiry |
| Titan Pharma India Private Limited | -67856931 | Mumbai, India | 84 | 58 | Inquiry |
| Kores (India) Limited | 91-22-27613455 | Maharashtra, India | 17 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |