(R)-(+)-1-(4-Methylphenyl)ethylamine
- CAS No.
- 4187-38-6
- Chemical Name:
- (R)-(+)-1-(4-Methylphenyl)ethylamine
- Synonyms
- Tolylethylamine;(R)-1-P-TOLYLETHANAMINE;Methyl phenyl-ethylamine;(+)-p,α-Dimethylbenzylamine;alpha,4-dimethylbenzylamine;(R)-1-(p-tolyl)ethan-1-amine;(R)-(+)-1-(P-TOLYL)ETHYLAMINE;(R)-(+)-A-(P-TOLYL)ETHYLAMINE;(R)-(+)-4-(1-AMINOETHYL)TOLUENE;(R)-alpha,p-Dimethylbenzylamine
- CBNumber:
- CB9311444
- Molecular Formula:
- C9H13N
- Molecular Weight:
- 135.21
- MOL File:
- 4187-38-6.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/11/20 10:14:03
| Melting point | <-20°C |
|---|---|
| Boiling point | 205 °C (lit.) |
| alpha | 37 º (NEAT) |
| Density | 0.919 g/mL at 25 °C (lit.) |
| refractive index |
n |
| Flash point | 180 °F |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| pka | 9.20±0.10(Predicted) |
| Specific Gravity | 0.919 |
| optical activity | [α]20/D +37°, neat |
| Sensitive | Air Sensitive |
| BRN | 3195425 |
| CAS DataBase Reference | 4187-38-6(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302+H312+H332-H314 | |||||||||
| Precautionary statements | P261-P280-P301+P312-P303+P361+P353-P304+P340+P310-P305+P351+P338 | |||||||||
| Hazard Codes | C | |||||||||
| Risk Statements | 20/21/22-34 | |||||||||
| Safety Statements | 16-26-27-36/37/39-45 | |||||||||
| RIDADR | UN 2619 8/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 2921490090 | |||||||||
| NFPA 704 |
|
(R)-(+)-1-(4-Methylphenyl)ethylamine price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 726664 | (R)-(+)-α,4-Dimethylbenzylamine ChiPros?, produced by BASF, 99% | 4187-38-6 | 5G | ₹5066.1 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 726664 | (R)-(+)-α,4-Dimethylbenzylamine ChiPros?, produced by BASF, 99% | 4187-38-6 | 25G | ₹20080.38 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 405248 | (R)-(+)-α,4-Dimethylbenzylamine 98% | 4187-38-6 | 1G | ₹6700.68 | 2022-06-14 | Buy |
(R)-(+)-1-(4-Methylphenyl)ethylamine Chemical Properties,Uses,Production
Chemical Properties
Colorless to light yellow liquid
Uses
(R)-(+)-α,4-Dimethylbenzylamine can be used as a chiral salt of keto acid, employed in the solid-state photolysis studies of α-mesitylacetophenone derivatives.
Application
(R)-(+)-α,4-Dimethylbenzylamine reacts with 1,5-difluoro-2,4-dinitrobenzene (DFDNB) to form a chiral derivative reagent(CDR) via substitution of one fluorine atom.
General Description
(R)-(+)-α,4-Dimethylbenzylamine is a chiral amine.
Synthesis
(R)-(+)-1-(4-methylphenyl)ethylamine was synthesized via a series of chemical reactions with (R)-N-[1-(4-methylphenyl)ethyl]acetamide. The steps are as follows:
1 g of the compound obtained in the previous stage will be used. 2 g of n-butanol was added, 0.63 g of potassium hydroxide was added, and the temperature was raised to 100 ° C. After 24 hours of heat preservation, cool down to 10 to 20 ℃. After adding water and stirring for 0.5 hours, the mixture was allowed to stand for separation, and the organic layer was concentrated to n-butanol, and then subjected to vacuum distillation (80-100 ℃ packed column) to obtain (R)-1-(4-methylphenyl)ethylamine 0.63 g. The yield was 82%, the HPLC purity was 96.3%, and the enantiomer was 0.8%.
structure and hydrogen bonding
(R)-(+)-1-(4-Methylphenyl)ethylamine is a chiral molecule studied in the context of crystallographic analysis and optimization. Through X-ray diffraction analysis, the crystal structure of (R)-(+)-1-(4-Methylphenyl)ethylamine was determined, revealing the presence of a significant hydrogen bond between the amine group and one of the carbonyl groups. This hydrogen bond plays a crucial role in stabilizing the (R)-(+)-1-(4-Methylphenyl)ethylamine molecule, which is a recurring pattern observed in structurally similar compounds. Furthermore, the (S)-(+)-enantiomer of (R)-(+)-1-(4-Methylphenyl)ethylamine was synthesized using an enantiopure precursor, establishing an efficient method to obtain this desired form of the molecule.
(R)-(+)-1-(4-Methylphenyl)ethylamine Preparation Products And Raw materials
(R)-(+)-1-(4-Methylphenyl)ethylamine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| BASF India Limited | +91-2262785600 +91-2262785600 | Maharashtra, India | 209 | 58 | Inquiry |
| Stereokem Pvt Ltd | +91-4029706929 +91-9394224843 | Telangana, India | 350 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| Clearsynth Labs | 91-22-45045900 | Maharashtra, India | 3889 | 58 | Inquiry |
| BASF India Limited | 91-22-67127600 | Maharashtra, India | 138 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Stereokem, Inc. | 500039 | New Delhi, India | 293 | 58 | Inquiry |
| Shanghai Jinli Pharmaceutical Co.,Ltd | +86-21-57256005 +86-15921811235 | China | 20 | 58 | Inquiry |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | China | 7353 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| BASF India Limited | 58 |
| Stereokem Pvt Ltd | 58 |
| CLEARSYNTH LABS LTD. | 58 |
| A.J Chemicals | 58 |
| Clearsynth Labs | 58 |
| BASF India Limited | 58 |
| TCI Chemicals (India) Pvt. Ltd. | 58 |
| Stereokem, Inc. | 58 |
| Shanghai Jinli Pharmaceutical Co.,Ltd | 58 |
| Jinan Carbotang Biotech Co.,Ltd. | 58 |