Salicyluric acid
- CAS No.
- 487-54-7
- Chemical Name:
- Salicyluric acid
- Synonyms
- NSC 524135;salicylurate;SALICYLGYCINE;SALICYLGLYCINE;salicyluricaci;SALICYLURIC ACID;Salicyloylglycine;TIMTEC-BB SBB000337;NSC 524135-13C2,15N;n-salicyloyl-glycin
- CBNumber:
- CB0292276
- Molecular Formula:
- C9H9NO4
- Molecular Weight:
- 195.17
- MOL File:
- 487-54-7.mol
- Modify Date:
- 2025/1/27 9:38:02
| Melting point | 164-169 °C |
|---|---|
| Boiling point | 331.83°C (rough estimate) |
| Density | 1.3544 (rough estimate) |
| refractive index | 1.5700 (estimate) |
| storage temp. | Store at 0°C |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Powder, Crystals or Chunks |
| pka | 3.68±0.10(Predicted) |
| color | White to light yellow |
| Stability | Hygroscopic |
| CAS DataBase Reference | 487-54-7(CAS DataBase Reference) |
| EPA Substance Registry System | Glycine, N-(2-hydroxybenzoyl)- (487-54-7) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P233-P260-P261-P264-P271-P280-P302+P352-P304-P304+P340-P305+P351+P338-P312-P321-P332+P313-P337+P313-P340-P362-P403-P403+P233-P405-P501 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 24/25-36/37/39-27-26 |
| RTECS | MR8160000 |
| HS Code | 29242998 |
Salicyluric acid Chemical Properties,Uses,Production
Description
Salicyluric acid is an N-acylglycine in which the acyl group is specified as 2-hydroxybenzoyl. It has a role as a uremic toxin and a human xenobiotic metabolite. It is a N-acylglycine and a secondary carboxamide. It is functionally related to a glycine. It is a conjugate acid of a salicylurate.
Chemical Properties
Light gray crystalline powder
Uses
Metabolite of Salicylic Acid (S088125).
2-Hydroxyhippuric acid is a phenol marker. Can be associated with dietary intake or bacterial overgrowth.
Indicators of Detoxification: A conjugate of the amino acid glycine and hydroxybenzoic acid (salicylic acid). Intake of aspirin (salicylates) or the growth of salicylate-producing gastrointestinal bacteria may elevate levels. Also increased after the ingestion of the artificial sweetener aspartame (Nutrasweet).
Definition
ChEBI: An N-acylglycine in which the acyl group is specified as 2-hydroxybenzoyl.
Synthesis
The synthesis of Salicyluric acid is as follows:
To a solution of 5 g of glycine in 50ml of 10%NaOH was stirred at room temperature upon slowaddition of salicyloyl chloride, and the resultingmixture was stirred overnight. Progress of the reaction was followed by TLC (hexane : ethylacetate, 7 : 3).Then the reaction mixture was treated with crushed iceupon stirring. Concentrated HCl was added dropwiseand stirring was continued until the mixture turnedacidic. For removing the residual benzoic acid the mixture was treated with 10-12 mL of CCl4, boiled and then filtered. A pinkish white solid was obtained, yield 90%, mp 165°C.
Salicyluric acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| OCEAN TRADING CORPORATION | +91(22) 24921669 | New Delhi, India | 6202 | 58 | Inquiry |
| Dhruvtara Chemicals Pvt. Ltd. | 91 40 27154607 | New Delhi, India | 180 | 56 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6100 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6257 | 58 | Inquiry |
| Nicholas Finechem Laboratories | 08048371812Ext 149 | Hyderabad, India | 59 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6514 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29810 | 58 | Inquiry |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | China | 29793 | 60 | Inquiry |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | China | 18940 | 58 | Inquiry |
| Hangzhou FandaChem Co.,Ltd. | +8615858145714 | China | 8771 | 55 | Inquiry |
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