2-[1,2-Bis-(4-fluoro-phenyl)-2-oxo-ethyl]-4-methyl-3-oxo-pentanoic acid phenylamide

2-[1,2-Bis-(4-fluoro-phenyl)-2-oxo-ethyl]-4-methyl-3-oxo-pentanoic acid phenylamide Structure
CAS No.
693793-82-7
Chemical Name:
2-[1,2-Bis-(4-fluoro-phenyl)-2-oxo-ethyl]-4-methyl-3-oxo-pentanoic acid phenylamide
Synonyms
Atorvastatin calcium-19;Atorvastatin Impurity 5;Atorvastatin Impurity 24;Atorvastatin Impurity 178;2-(1,2-bis(4-fluorophenyl);Atorvastatin Difluoro Impurity;Atorvastatin calcium impurity 27;Atorvastatin Calcium Hydrate impurity 37;2-(1,2-bis(4-fluorophenyl)-2-oxoethyl)-4-methyl-3-oxo-N-phenylpentanamide;2-[1,2-Bis-(4-fluoro-phenyl)-2-oxo-ethyl]-4-methyl-3-oxo-pentanoic acid phenylamide
CBNumber:
CB03312504
Molecular Formula:
C26H23F2NO3
Molecular Weight:
435.46
MOL File:
693793-82-7.mol

2-[1,2-Bis-(4-fluoro-phenyl)-2-oxo-ethyl]-4-methyl-3-oxo-pentanoic acid phenylamide Properties

Boiling point 633.7±55.0 °C(Predicted)
Density 1.248±0.06 g/cm3(Predicted)
pka 11.49±0.59(Predicted)

2-[1,2-Bis-(4-fluoro-phenyl)-2-oxo-ethyl]-4-methyl-3-oxo-pentanoic acid phenylamide Chemical Properties,Uses,Production

Uses

4-Fluoro-β-(4-fluorophenyl)-α-(2-methyl-1-oxopropyl)-γ-oxo-N-phenylbenzenebutanamide is an intermediate in the synthesis of Difluoro Atorvastatin Acetonide tert-Butyl Ester (D445455), a useful synthetic intermediate in the synthesis of Difluoro Atorvastatin (D445660); an Atorvastatin impurity.

2-[1,2-Bis-(4-fluoro-phenyl)-2-oxo-ethyl]-4-methyl-3-oxo-pentanoic acid phenylamide Preparation Products And Raw materials

Raw materials

Preparation Products

2-[1,2-Bis-(4-fluoro-phenyl)-2-oxo-ethyl]-4-methyl-3-oxo-pentanoic acid phenylamide Atorvastatin Impurity 24 2-(1,2-bis(4-fluorophenyl)-2-oxoethyl)-4-methyl-3-oxo-N-phenylpentanamide Atorvastatin Impurity 5 Atorvastatin impurity 18/2-(1,2-bis(4-fluorophenyl)-2-oxoethyl)-4-methyl-3-oxo-N- phenylpentanamide (3R,5R)-tert-butyl 7-(2-(2-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate Atorvastatin Calcium Hydrate impurity 37 2-(1,2-bis(4-fluorophenyl) Atorvastatin calcium-19 Benzenebutanamide, 4-fluoro-β-(4-fluorophenyl)-α-(2-methyl-1-oxopropyl)-γ-oxo-N-phenyl- Atorvastatin Impurity 178 4-Fluoro-β-(4-fluorophenyl)-α-(2-methyl-1-oxopropyl)-γ-oxo-N-phenylbenzenebutanamide Atorvastatin Difluoro Impurity Atorvastatin calcium impurity 27 693793-82-7 C26H23F2NO3