TMS

CAS No.: 24144-92-1

Chemical Name:: TMS

Synonyms: CS-961;SMB 00388;TMS, >=98%;5'-tetramethoxystilbene;3,5,2’,4’-Tetramethoxystilbene;2,3',4,5'-TETRAMETHOXYSTILBENE;(E)-2,3',4,5'-TETRAMETHOXYSTILBENE;TMS - Trans-2,3',4,5'-tetramethoxystilbene;(E)-1-(3,5-Dimethoxystyryl)-2,4-dimethoxybenzene;1-[2,(3,5-DIMETHOXYPHENYL)ETHENYL]-2,4-DIMETHOXYBENZENE

CBNumber:: CB0347220

Molecular Formula:: C18H20O4

Molecular Weight:: 300.35

MOL File:: 24144-92-1.mol

MSDS File:: SDS

Modify Date:: 2024/7/2 8:54:58

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TMS Properties

Melting point	78-79 °C
Boiling point	459.9±40.0 °C(Predicted)
Density	1.117±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Store in freezer, under -20°C
solubility	DMF: 30 mg/ml; DMF:PBS (pH 7.2) (1:1): 500 μg/ml; DMSO: 20 mg/ml; Ethanol: 400 μg/ml
form	Powder
color	Light yellow to yellow

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302

Precautionary statements

P280-P305+P351+P338

NFPA 704

	0
2		0

TMS Chemical Properties,Uses,Production

Uses

CYP1B1 is mainly an extrahepatic enzyme which oxidatively metabolizes both endogenous (steroids; eicosanoids) and exogenous xenobiotics such aspolyaromatic hydrocarbons. TMS is a potent and selective inhibitor of CYP1B1, with an IC50 of 6 nM. It is 50-fold selective for the inhibition of CYP1B1 versus CYP1A1, making it a useful tool to differentiate between various CYP450 families. In cultured human colon cancer cells, TMS induces apoptosis and inhibits cell growth with an IC50 of 0.8 μg/ml.

Biological Activity

Potent, selective and competitive inhibitor of cytochrome P450 1B1, an enzyme overexpressed in certain tumors (IC 50 = 6 nM). 50- and 520-fold selective over P450 1A1 and 1A2 respectively. Inhibits cancer cell growth in vitro .

TMS Preparation Products And Raw materials

Raw materials

Preparation Products

TMS Suppliers

Global( 84)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	China	32760	60	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29826	58	Inquiry
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	China	10522	58	Inquiry
InvivoChem	+1-708-310-1919 +1-13798911105	United States	6393	58	Inquiry
LEAP CHEM CO., LTD.	+86-852-30606658	China	24738	58	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354	United States	19973	58	Inquiry
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	China	11681	58	Inquiry
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	China	8474	58	Inquiry

Supplier	Advantage
CLEARSYNTH LABS LTD.	58
A.J Chemicals	58
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Zhejiang J&C Biological Technology Co.,Limited	58
InvivoChem	58
LEAP CHEM CO., LTD.	58
TargetMol Chemicals Inc.	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	58
Wuhan Topule Biopharmaceutical Co., Ltd	58

24144-92-1(TMS)Related Search:

4-NITROSTYRENE TOLUENE-D8, 99 ATOM % D (CONTAINS 1% V/V TMS) N-METHYL-N-TRIMETHYLSILYLHEPTAFLUOROBUTYRAMIDE (TMS REAGENT FOR GC USING FID) 95+% Methanol-d4 DIMETHYL SULFOXIDE-D6

1-TMS-1H-BENZOTRIAZOLE POLY(DIMETHYLSILOXANE-CO-METHYLHYDRO-SIL OXANE), TMS TERM, VISC CA. 260 CST Acetonitrile-d3 Benzene-D6 Tetrakis(trimethylsilyl)silane ((TMS)4Si )

Pyridine-d5, contains 1 v/v% TMS, 99 atom % D, for NMR,Pyridine-d5, with 0.03% TMS, 100.0 atom% D, for NMR Chloroform-d ACETONE-D6 TMS-BA [=N,O-BIS(TRIMETHYLSILYL)ACETAMIDE] 25% IN ACETONITRILE [FOR GAS CHROMATOGRAPHY] N,N-DIMETHYLFORMAMIDE-D7, 99.5 ATOM % D (CONTAINS 1% V/V TMS)

1-(TMS)ETHYNYLCYCLOHEXENE 1-TMS-1H-BENZOTRIAZOLE Cytochrome P450 1B1 Inhibitor, TMS

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(E)-2,3',4,5'-TETRAMETHOXYSTILBENE 2,3',4,5'-TETRAMETHOXYSTILBENE 1-[(1E)-2-(3,5-DIMETHOXYPHENYL)ETHENYL]-2,4-DIMETHOXY-BENZENE 1-[2,(3,5-DIMETHOXYPHENYL)ETHENYL]-2,4-DIMETHOXYBENZENE 3,5,2’,4’-Tetramethoxystilbene Benzene, 1-[(1E)-2-(3,5-diMethoxyphenyl)ethenyl]-2,4-diMethoxy- (E)-1-(3,5-Dimethoxystyryl)-2,4-dimethoxybenzene TMS, >=98% TMS - Trans-2,3',4,5'-tetramethoxystilbene CS-961 5'-tetramethoxystilbene SMB 00388 24144-92-1 Antitumour