1-[4-(1,2,3,4-TETRAHYDROXYBUTYL)-1H-IMIDAZOL-2-YL]ETHANONE
![1-[4-(1,2,3,4-TETRAHYDROXYBUTYL)-1H-IMIDAZOL-2-YL]ETHANONE Structure](CAS/GIF/94944-70-4.gif)
- CAS No.
- 94944-70-4
- Chemical Name:
- 1-[4-(1,2,3,4-TETRAHYDROXYBUTYL)-1H-IMIDAZOL-2-YL]ETHANONE
- Synonyms
- 2-Athbi;Inhibitor,inhibit,2 ATHBI,2ATHBI;2-Acetyl-5-tetrahydroxybutyl Imidazole;2-acetyl-4(5)-tetrahydroxybutylimidazole;2-Acetyl-5-tetrahydroxybutyl iMidazole (THI);2-Acetyl-4-tetrahydroxybutylimidazole Standard;2-Acetyl-4-(1,2,3,4-tetrahydroxybutyl)iMidazole, 97%;2-Acetyl-4-(1,2,3,4-tetrahydroxybutyl)imidazole, 97%,;(R,S,R)-2-Acetyl-4-(1,2,3,4-tetrahydroxybutyl)-imidazole;2-ACETYL-4(5)-(1,2,3,4-TETRAHYDROXYBUTYL)-IMIDAZOLE (THI)
- CBNumber:
- CB0371535
- Molecular Formula:
- C9H14N2O5
- Molecular Weight:
- 230.22
- MOL File:
- 94944-70-4.mol
- Modify Date:
- 2024/10/31 18:15:48
| Melting point | approximate 230℃ (dec.) |
|---|---|
| Boiling point | 613.5±65.0 °C(Predicted) |
| Density | 1.536±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: soluble2mg/mL, clear (warmed) |
| form | Powder |
| pka | 10.63±0.10(Predicted) |
| color | white to light brown |
| Water Solubility | Soluble in distilled water, DMSO (>5 mg/ml), clear (warmed), and PBS pH 7.2 (~0.15 mg/ml). |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 3 months. |
| CAS DataBase Reference | 94944-70-4 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312a-P330-P501a | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 29332900 | |||||||||
| NFPA 704 |
|
1-[4-(1,2,3,4-TETRAHYDROXYBUTYL)-1H-IMIDAZOL-2-YL]ETHANONE price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | T6330 | THI | 94944-70-4 | 1MG | ₹20762.35 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | T6330 | THI | 94944-70-4 | 5MG | ₹85528.33 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | T6330 | THI | 94944-70-4 | 25MG | ₹224294 | 2022-06-14 | Buy |
| ALFA India | ALF-H63416-MD | 2-Acetyl-4-(1,2,3,4-tetrahydroxybutyl)imidazole, 97% | 94944-70-4 | 250mg | ₹206502 | 2022-05-26 | Buy |
1-[4-(1,2,3,4-TETRAHYDROXYBUTYL)-1H-IMIDAZOL-2-YL]ETHANONE Chemical Properties,Uses,Production
Uses
Sphingosine-1-phosphate (S1P) lyase catalyzes the irreversible decomposition of S1P to hexadecanaldehyde and phosphoethanolamine. 2-Acetyl-5-tetrahydroxybutyl imidazole (THI) is an inhibitor of S1P lyase. Because S1P lyase is primarily expressed in lymphatic tissue, treatment of mice with THI (50 μg/ml in drinking water) increases lymphoid tissue S1P concentrations 100-fold, reducing lymphocyte egress from thymus and peripheral lymphoid organs. The resulting lymphopenia is reversible following cessation of THI treatment. Reducing S1P lyase activity results in therapeutic levels of immunosuppression without the non-lymphoid lesions that result from synthetic S1P receptor agonists.
Biochem/physiol Actions
2-Acetyl-5-tetrahydroxybutyl imidazole (THI) can block S1P lyase in vivo and up-regulates circulatory and tissue S1P levels. It has the ability to repress dystrophic muscle degeneration.
1-[4-(1,2,3,4-TETRAHYDROXYBUTYL)-1H-IMIDAZOL-2-YL]ETHANONE Preparation Products And Raw materials
Raw materials
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1-[4-(1,2,3,4-TETRAHYDROXYBUTYL)-1H-IMIDAZOL-2-YL]ETHANONE Suppliers
Global( 56)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Alfa Aesar | 1 800 209 7001 | Maharashtra, India | 6905 | 58 | Inquiry |
| BOC Sciences | +1-631-485-4226 | United States | 19553 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 32038 | 58 | Inquiry |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | China | 33338 | 58 | Inquiry |
| SHANGHAI KEAN TECHNOLOGY CO., LTD. | +8613817748580 | China | 40066 | 58 | Inquiry |
| TargetMol Chemicals Inc. | 4008200310 | China | 24649 | 58 | Inquiry |
| Shanghai Kewel Chemical Co., Ltd. | 021-64609169 18901607656 | China | 9906 | 50 | Inquiry |
| Auonsi (Shanghai) Biology Technology Co., Ltd. | 400-1107768 15058188853 | China | 8552 | 58 | Inquiry |
| Shanghai Saikerui Biotechnology Co. , Ltd. | 021-58000709 13052382393 | China | 9264 | 58 | Inquiry |
| Shanghai Maclean Biochemical Technology Co., LTD | 021-50706066 15221275939 | China | 29794 | 58 | Inquiry |
94944-70-4(1-[4-(1,2,3,4-TETRAHYDROXYBUTYL)-1H-IMIDAZOL-2-YL]ETHANONE)Related Search:
1-[4-(1,2,3,4-TETRAHYDROXYBUTYL)-1H-IMIDAZOL-2-YL]ETHANONE
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2-ACETYL-4(5)-(1,2,3,4-TETRAHYDROXYBUTYL)-IMIDAZOLE (THI)
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Inhibitor,inhibit,2 ATHBI,2ATHBI
94944-70-4