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ChemicalBook > Product Catalog >Inorganic chemistry >Inorganic salts >Hydrides, nitrides, azides >Hydride >5α-Pregnane-3,20-dione

5α-Pregnane-3,20-dione

5α-Pregnane-3,20-dione Structure
CAS No.
566-65-4
Chemical Name:
5α-Pregnane-3,20-dione
Synonyms
Pregnane-3,20-dione;5α-dihydroprogesterone;5α-Dihydroprogesterone;5α-pregnane-3,20-dione;ALLOPREGNANDIONE;Allopregnanedione;Pregnane-3,20-dlone;Estrone Impurity 23;5A-PREGNAN-3,20-DIONE;5A-DIHYDROPROGESTERONE
CBNumber:
CB0377209
Molecular Formula:
C21H32O2
Molecular Weight:
316.48
MOL File:
566-65-4.mol
Modify Date:
2024/3/22 17:12:53
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5α-Pregnane-3,20-dione Properties

Melting point 200 °C
Boiling point 429.2±38.0 °C(Predicted)
Density 1.048±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
solubility Chloroform (Slightly), Ethyl Acetate (Slightly)
form Solid
color White to Off-White
InChI InChI=1S/C21H32O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h14,16-19H,4-12H2,1-3H3/t14?,16-,17+,18-,19-,20-,21+/m0/s1
InChIKey XMRPGKVKISIQBV-CVHNGYJVSA-N
SMILES C1(=O)CC2[C@](C)(CC1)[C@]1([H])[C@]([H])([C@@]3([H])[C@@](CC1)(C)[C@@H](C(=O)C)CC3)CC2
CAS DataBase Reference 566-65-4(CAS DataBase Reference)
NIST Chemistry Reference 3,20-Allopregnanedione(566-65-4)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07,GHS08
Signal word  Warning
Hazard statements  H312-H302-H332-H351-H361fd
Precautionary statements  P280-P302+P352-P312-P322-P363-P501-P264-P270-P301+P312-P330-P501-P201-P202-P281-P308+P313-P405-P501-P261-P271-P304+P340-P312
WGK Germany  3
RTECS  TU4157150
HS Code  2937.29.9095

5α-Pregnane-3,20-dione price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) P7754 5α-Pregnane-3,20-dione (allo) progesterone metabolite 566-65-4 500MG ₹5250.13 2022-06-14 Buy
Sigma-Aldrich(India) P7754 5α-Pregnane-3,20-dione (allo) progesterone metabolite 566-65-4 1G ₹8746.6 2022-06-14 Buy
TCI Chemicals (India) P2423 5α-Pregnane-3,20-dione min. 98.0 % 566-65-4 1G ₹5000 2022-05-26 Buy
TCI Chemicals (India) P2423 5α-Pregnane-3,20-dione min. 98.0 % 566-65-4 5G ₹11800 2022-05-26 Buy
Product number Packaging Price Buy
P7754 500MG ₹5250.13 Buy
P7754 1G ₹8746.6 Buy
P2423 1G ₹5000 Buy
P2423 5G ₹11800 Buy

5α-Pregnane-3,20-dione Chemical Properties,Uses,Production

Uses

(5α)-Pregnane-3,20-dione exerts neuroprotective effects in chronic autoimmune encephalomyelitis (EAE). The neuroactivity of the steroid acts as a therapeutic agent for multiple sclerosis.

Definition

ChEBI: 5alpha-pregnane-3,20-dione is a C21-steroid hormone that is 5alpha-pregnane substituted by oxo groups at positions 3 and 20. It is a metabolite of progestrone. It has a role as a human metabolite and a progestogen. It is a 20-oxo steroid, a C21-steroid hormone and a 3-oxo-5alpha-steroid. It is functionally related to a progesterone. It derives from a hydride of a 5alpha-pregnane.

Biological Activity

Digestive gland subcellular fractions readily converted P4 into 5-pregnane-3,20-dione and minor amounts of a second metabolite and then 5-pregnane-3,20-dione was further metabolized to 3-hydroxy-5-pregnane-20-one (3,20-one) by 3β-HSD. This reaction was significantly inhibited by trilostane which is a 3β-HSD inhibitor[1-2].

References

[1] Dimastrogiovanni G, et al. Progesterone is actively metabolized to 5-pregnane-3,20-dione and 3-hydroxy-5-pregnan-20-one by the marine mussel Mytilus galloprovincialis. Aquatic Toxicology, 2015; 73-100.
[2] Ankley G, et al. Effects?of?progesterone?on?sperm motility?in?fathead?minnow. Aquatic Toxicology, 2011; 104: 121-125.

5α-Pregnane-3,20-dione Preparation Products And Raw materials

Raw materials

PREGNANEDIONE Progesterone

Preparation Products

Pregnan-20-one, 3-hydroxy-3-methyl-, (3β,5α)- GANAXOLONE Pregnan-20-one, (5alpha)-

5α-Pregnane-3,20-dione Suppliers

Global( 166)Suppliers
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JIVICHEM SYNTHESIS PVT LTD +91-7028392790 +91-7028392790 Maharashtra, India 337 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
TCI Chemicals (India) Pvt. Ltd. 1800 425 7889 New Delhi, India 6778 58 Inquiry
Pharmaceuticals Group Corp., Ltd. +8613004379774 China 33 58 Inquiry
Wuhan Han Sheng New Material Technology Co.，Ltd +8617798174412 China 2118 58 Inquiry
Nanjing Shizhou Biotechnology Co., Ltd +86-15850508050 +86-15850508050 China 323 58 Inquiry
Nantong Guangyuan Chemicl Co,Ltd +undefined17712220823 China 616 58 Inquiry
Capot Chemical Co.,Ltd. 571-85586718 +8613336195806 China 29798 60 Inquiry
Shanghai Daken Advanced Materials Co.,Ltd +86-371-66670886 China 16221 58 Inquiry
Henan Tianfu Chemical Co.,Ltd. +86-0371-55170693 +86-19937530512 China 21677 55 Inquiry
Supplier Advantage
JIVICHEM SYNTHESIS PVT LTD 58
CLEARSYNTH LABS LTD. 58
TCI Chemicals (India) Pvt. Ltd. 58
Pharmaceuticals Group Corp., Ltd. 58
Wuhan Han Sheng New Material Technology Co.，Ltd 58
Nanjing Shizhou Biotechnology Co., Ltd 58
Nantong Guangyuan Chemicl Co,Ltd 58
Capot Chemical Co.,Ltd. 60
Shanghai Daken Advanced Materials Co.,Ltd 58
Henan Tianfu Chemical Co.,Ltd. 55

566-65-4(5α-Pregnane-3,20-dione)Related Search:

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5-ALPHA-DIHYDROCORTISONE 5-ALPHA-DIHYDROCORTICOSTERONE 17-ALPHA-HYDROXY-5-ALPHA-PREGNANE-3,20-DIONE 5-ALPHA-DIHYDRO SUBSTANCE 'S' ALLOPREGNANETRIONE
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ALLOPREGNANE-3,20-DIONE ALLOPREGNAN-3,20-DIONE ALLOPREGNANDIONE (5S,8R,9S,10S,13S,14S,17S)-17-ACETYL-10,13-DIMETHYL-HEXADECAHYDRO-CYCLOPENTA[A]PHENANTHREN-3-ONE 5 A-PREGNANE-3 20-DIONE 5A-PREGNAN-3,20-DIONE 5ALPHA-PREGNANE-3,20-DIONE (ALLO) 5ALPHA-DIHYDROPROGESTERONE 5-ALPHA-PREGNAN-3,20-DIONE 5A-DIHYDROPROGESTERONE (5-alpha)-pregnane-20-dione 3,20-Allopregnanedione 3,20-Dioxo-5alpha-pregnane 5alpha-Pregnane-3,20-dione 5-beta-pregnane-3,20-dione Pregnane-3,20-dione, (5alpha)- 5A-pregnane-3-20-dione-allo 5alpha-Pregnan-3,20-dione-1,2,4,5,6,7-D6 5α-pregnane-3,20-dione (allo) (5S,8R,9S,10S,13R,14S,17S)-17-acetyl-10,13-dimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-3-one 4-07-00-02199 (Beilstein Handbook Reference) 5 A-PREGNANE-3 20-DIONE 99% 5α-Pregnan-3,20-dione-1,2,4,5,6,7-D6 5α-Dihydroprogesterone, Allopregnane-3,20-dione (5S,8R,9S,10S,13S,14S,17S)-17-Acetyl-10,13-dimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-3-one Allopregnanedione ALLOPREGNENDIONE(RG)(CALL) 5α-Pregnane-3,20-dione (allo),5α-Dihydroprogesterone, Allopregnane-3,20-dione Hydrogenated progesterone 5alpha-Pregnane-3,20-dione (allo) progesterone metabolite (8R,9S,10S,13S,14S,17S)-17-acetyl-10,13-dimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-3-one (8R,9S,10S,13S,14S,17S)-17-ethanoyl-10,13-dimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-3-one 5-Alpha-Dihydro Progesterone-d8 Pregnane-3,20-dlone Pregnane-3,20-dione, (5α)- PREGNANE-3,20-DIONE CAS NO 566-65-4 5-alpha-Dihydroprogesterone ISO 9001：2015 REACH Estrone Impurity 23 566-65-4 5-alpha-Dihydroprogesterone Pregnane-3,20-dione 5α-dihydroprogesterone 5α-pregnane-3,20-dione 5α-Dihydroprogesterone 5a-Pregnane-3,20-Dione（Dihydroprogesterone） (5S,8R,9S,10S,13S,14S,17S)-17-Acetyl-10,13-dimethyltetradecahydro-1H-cyclopenta[a]phenanthren-3(2H)-one Pregnenolone Impurity 13 5α-PREGNAN-3, 20-DIONE 566-65-4 Steroids 566-65-4