GANAXOLONE
- CAS No.
- 38398-32-2
- Chemical Name:
- GANAXOLONE
- Synonyms
- Fampridine Impurity 80;5α-PREGNAN-3β-METHYL-3α-;5α-PREGNAN-3β-METHYL-3α-OL-20-ONE;3α-hydroxy-3β-methyl-5α-pregnan-20-one;3α-hydroxy-3β-methyl-5α-pregnan-20-one;(3α,5α)-3-Hydroxy-3-methylpregnan-20-one;(3α,5α)-3-Hydroxy-3-methyl-pregnan-20-one;Pregnan-20-one, 3-hydroxy-3-methyl-, (3α,5α)-;1-((3R,5S,8R,9S,10S,13S,14S,17S)-3-Hydroxy-3,10,13-trimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)ethanone;1-[(3R,5S,8R,9S,10S,13S,14S,17S)-3-hydroxy-3,10,13-trimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]ethanone
- CBNumber:
- CB8498146
- Molecular Formula:
- C22H36O2
- Molecular Weight:
- 332.52
- MOL File:
- 38398-32-2.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/6/30 15:45:59
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302+H312+H332 |
| Safety Statements | 22-24/25 |
| WGK Germany | 3 |
| RTECS | TU4384700 |
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GANAXOLONE Chemical Properties,Uses,Production
Description
Ganaxolone is a 3β-methylated synthetic analog of the neurosteroid allopregnanolone that allosterically enhances GABAA receptor current. At nanomolar concentrations, it can potentiate GABA-evoked currents at GABAA receptor complexes containing α1, α2, α3, β2, and γ2L subunits expressed in Xenopus oocytes. Ganaxolone has been shown to have a broad range of antiseizure activity in animal epilepsy models and human clinical trials.
Uses
Ganaxolone, is synthetic neuroactive steroid, which possess sedative, anxiolytic, and anticonvulsant properties. It is also a potent and selective positive allosteric modulator of GABAA receptors. It is also shown to be used for the treatment of epilepsy.
Biological Activity
Potent positive allosteric modulator of GABA A receptors. Enhances GABA-evoked chloride currents in Xenopus oocytes expressing GABA A receptors (EC 50 values are 94, 122 and 213 nM for α 2 β 1 γ 2 L , α 3 β 1 γ 2 L and α 1 β 1 γ 2 L receptors respectively). Exerts anticonvulsive effects in a broad range of animal seizure models.
GANAXOLONE Preparation Products And Raw materials
Raw materials
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GANAXOLONE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| Hunan Yuanye Pharmaceutical Co., Ltd. | +8615857615745 | China | 87 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29825 | 58 | Inquiry |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | China | 10522 | 58 | Inquiry |
| InvivoChem | +1-708-310-1919 +1-13798911105 | United States | 6393 | 58 | Inquiry |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | China | 49739 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 | United States | 19973 | 58 | Inquiry |