Gestrinone
- CAS No.
- 16320-04-0
- Chemical Name:
- Gestrinone
- Synonyms
- ru2323;r-2323;A-46745;Dimetrose;NeMestran;TridoMose;gestrigone;GESTRINONE;Dimetriose;gestinone.
- CBNumber:
- CB3121391
- Molecular Formula:
- C21H24O2
- Molecular Weight:
- 308.41
- MOL File:
- 16320-04-0.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/2 8:55:04
| Melting point | 150-152°C |
|---|---|
| alpha | D20 +84.6° (c = 0.41 in methanol) |
| Boiling point | 388.8°C (rough estimate) |
| Density | 1.1040 (rough estimate) |
| refractive index | 1.4900 (estimate) |
| storage temp. | -20°C Freezer |
| solubility |
DMF:20.0(Max Conc. mg/mL);64.85(Max Conc. mM) DMSO:35.0(Max Conc. mg/mL);113.48(Max Conc. mM) Ethanol:20.0(Max Conc. mg/mL);64.85(Max Conc. mM) Ethanol:PBS (pH 7.2) (1:5):0.25(Max Conc. mg/mL);81.06(Max Conc. mM) Water:1.0(Max Conc. mg/mL);3.24(Max Conc. mM) |
| form | A crystalline solid |
| pka | 12.76±0.40(Predicted) |
| color | Off-white to light yellow |
| Merck | 14,4415 |
| Stability | Hygroscopic |
| InChI | InChI=1S/C21H24O2/c1-3-20-11-9-17-16-8-6-15(22)13-14(16)5-7-18(17)19(20)10-12-21(20,23)4-2/h2,9,11,13,18-19,23H,3,5-8,10,12H2,1H3/t18-,19+,20+,21+/m1/s1 |
| InChIKey | BJJXHLWLUDYTGC-ANULTFPQSA-N |
| SMILES | C1C2C(CC[C@]3([H])C=2C=C[C@@]2(CC)[C@@]3([H])CC[C@]2(C#C)O)=CC(=O)C1 |
| CAS DataBase Reference | 16320-04-0(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Danger |
| Hazard statements | H360-H362 |
| Precautionary statements | P201-P260-P263-P264-P270-P308+P313 |
| RTECS | JF7964000 |
| Toxicity | mouse,LDLo,intraperitoneal,1gm/kg (1000mg/kg),BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLDBEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)GASTROINTESTINAL: OTHER CHANGES,Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 16, Pg. 701, 1988. |
Gestrinone Chemical Properties,Uses,Production
Description
Gestrinone is a synthetic steroid with antiprogesterone and antiestrogenic activities. It is reported to be useful in the treatment of endometriosis and uterine leiom yomas.
Chemical Properties
Light Yellow Solid
Uses
Steroidal antiestrogen, antiprogestogen, analog of Norgestrienone. Antigonadotropin. Controlled substance.
Side effects
Gestrinone, like danazol, inhibits the synthesis of estrogens and progestogens and has been used mainly to prepare patients with an endometrial disorder for hysterectomy. Its most common adverse effects are nausea, headache, mood changes, rash, hot flushes, weight gain, and discomfort in the joints and muscles. In some cases, there is evidence of masculinization.
Mode of action
The primary action of gestrinone is on the hypothalamic-pituitary axis, where it inhibits gonadotrophin release with a weak inhibitory effect on its synthesis. It also possesses anti-estrogen activity. The mode of action of gestrinone used for EC is probably inhibition of implantation by acting on the endometrium rather than inhibiting ovulation[1].
References
[1] Xuefeng Gao, Guian Chen, Erruo Wu . “Mechanism of emergency contraception with gestrinone: a preliminary investigation.” Contraception 76 3 (2007): Pages 221-227.
Gestrinone Preparation Products And Raw materials
Raw materials
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chevron_rightPreparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6768 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6739 | 58 | Inquiry |
| Liaoning Pharmaceutical Innovation Co., Ltd | +8616588669988 | China | 151 | 58 | Inquiry |
| Nantong Guangyuan Chemicl Co,Ltd | +undefined17712220823 | China | 615 | 58 | Inquiry |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | China | 21634 | 55 | Inquiry |
| Xiamen AmoyChem Co., Ltd | +86-86-5926051114 +8618959220845 | China | 6383 | 58 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49374 | 58 | Inquiry |
| Nanjing Shizhou Biotechnology Co., Ltd | +86-15850508050 +86-15850508050 | China | 323 | 58 | Inquiry |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | China | 30237 | 58 | Inquiry |
| Hunan Jibang Biological Technology Co., LTD | +8613776644403 | China | 1804 | 58 | Inquiry |
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