Pyruvic acid
- CAS No.
- 127-17-3
- Chemical Name:
- Pyruvic acid
- Synonyms
- 2-OXOPROPANOIC ACID;Propanoic acid, 2-oxo-;pyruvic;CH3COCOOH;2-oxo-propanoicaci;NSC 179;FEMA 2970;PYRUVIC ACID;Pyruvia Acid;ACID PYRUVATE
- CBNumber:
- CB5257557
- Molecular Formula:
- C3H4O3
- Molecular Weight:
- 88.06
- MOL File:
- 127-17-3.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/6/28 14:34:47
| Melting point | 11-12 °C (lit.) |
|---|---|
| Boiling point | 165 °C (lit.) |
| Density | 1.267 g/mL at 25 °C (lit.) |
| vapor pressure | 1.72hPa at 25℃ |
| refractive index |
n |
| FEMA | 2970 | PYRUVIC ACID |
| Flash point | 183 °F |
| storage temp. | 2-8°C |
| solubility | Miscible with chloroform and methanol. |
| pka | 2.39(at 25℃) |
| form | Liquid |
| color | Clear colorless to light yellow or amber |
| PH | 3.11(1 mM solution);2.38(10 mM solution);1.79(100 mM solution); |
| Odor | at 1.00 % in propylene glycol. sharp sour acetic caramellic |
| Odor Type | acidic |
| Merck | 14,8021 |
| JECFA Number | 936 |
| BRN | 506211 |
| Stability | Stable. Combustible. Incompatible with strong oxidizing agents, strong bases. Refrigerate. |
| InChIKey | LCTONWCANYUPML-UHFFFAOYSA-N |
| LogP | -1.24 |
| Dissociation constant | 2.49 at 25℃ |
| CAS DataBase Reference | 127-17-3(CAS DataBase Reference) |
| NIST Chemistry Reference | Pyruvic acid(127-17-3) |
| EPA Substance Registry System | Propanoic acid, 2-oxo- (127-17-3) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H314 | |||||||||
| Precautionary statements | P280-P301+P330+P331-P303+P361+P353-P305+P351+P338 | |||||||||
| Hazard Codes | C | |||||||||
| Risk Statements | 34 | |||||||||
| Safety Statements | 26-36/37/39-45-25-27 | |||||||||
| RIDADR | UN 3265 8/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | UZ0829800 | |||||||||
| Autoignition Temperature | 305 °C | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29335995 | |||||||||
| NFPA 704 |
|
Pyruvic acid price More Price(24)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | W297070 | Pyruvic acid natural, ≥95%, FG | 127-17-3 | 1SAMPLE-K | ₹5347.55 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | W297070 | Pyruvic acid natural, ≥95%, FG | 127-17-3 | 25G | ₹7382.65 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | W297070 | Pyruvic acid natural, ≥95%, FG | 127-17-3 | 100G | ₹23912.43 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | W297070 | Pyruvic acid natural, ≥95%, FG | 127-17-3 | 1KG | ₹159095.03 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | W297003 | Pyruvic acid ≥97%, FG | 127-17-3 | 1SAMPLE-K | ₹5141.88 | 2022-06-14 | Buy |
Pyruvic acid Chemical Properties,Uses,Production
Chemical Properties
Pyruvic acid has a sour, acetic odor (similar to acetic acid). It has a pleasant, sour taste with a burning, somewhat sweet note. It tends to darken and decompose unless kept free of minor contaminants and in tightly sealed containers
Occurrence
Isolated from cane sugar fermentation broth and from a few plants; also reported found in peppermint, raw asparagus, leaves and stalk of celery, onion, rutabaga, milk, cream, buttermilk, wheaten bread, blue cheeses, cheddar cheese, cottage cheese, provolone cheese, yogurt, beef, Virginia tobacco, beer, white wine, botrytised wine, cocoa and sake.
Uses
pyruvic acid is an alpha hydroxy acid that can be irritating and is considered difficult to work with. It has a larger molecular size than the most commonly used AHAs. Sodium pyruvate is more commonly used, and is an organic salt.
Preparation
By distillation of tartaric acid in the presence of potassium acid sulfate as a dehydrating agent; from acetyl chloride and potassium cyanide to yield the nitrile, which is subsequently acid hydrolyzed to the acid; pyruvic acid must be rectified under vacuum.
Definition
Pyruvic acid is an important organic chemical intermediate, an intermediate compound in the metabolism of carbohydrates, proteins, and fats, and is used in a variety of fields, including the pharmaceutical, cosmetic, food, and chemical industries. It has roles as a basic metabolite and cofactor. In thiamine deficiency, its oxidation is retarded and it tends to accumulate in neurostructural tissues causing neurological damage. In vitro studies have shown that pyruvic acid modulates cardiac function at physiological or low doses, but can cause cardiomyocyte damage at high doses.
General Description
Pyruvic acid is the key component formed during the hydrolysis of flavor-precursors called S-alk(en)yl-L-cysteine-sulfoxides in onion tissues by allinase during maceration or chopping. The amount of pyruvic acid formed is used as a measure for onion pungency.
Biotechnological Applications
Pyruvic acid is a key position in cell metabolism and is involved in many catabolic and anabolic pathways, including glycolysis, gluconeogenesis, amino acid, and protein metabolism. Pyruvic acid is employed for the production of L-tryptophan, L-tyrosine, and 3,4-dihydroxyphenyl alanine in various industries. The diet supplementation with pyruvic acid increased fat loss and minimized the associated loss of body protein. Pyruvic acid is also used in biochemical researches and medicine as a substrate for assaying activities of such enzymes as pyruvate dehydrogenase, pyruvate carboxylase, and pyruvate decarboxylase (Nakazawa et al. 1972; Yamada et al. 1972; Stanko et al. 1992).
Y. lipolytica oxidize glucose and form pyruvic acid (75–80 %) and a-ketoglutaric acid (20–25 %) under thiamine deficiency conditions. The synthesis of the acid was triggered by a decrease in intracellular thiamine concentration to 3.0 lg per 1 g biomass. An approximately 3-fold increase in the amount of the biomass was associated with a subsequent decrease in thiamine content to the level of 1.0 lg per 1 g biomass, whose maximum production of pyruvic acid was 50 g/L in this condition. In addition to glucose, thiamine-auxotrophic yeasts are capable of synthesizing pyruvic acid when grown on glycerol and propionic acid. Technicalgrade glycerol is the most promising raw material for pyruvic acid production. Pyruvic acid was obtained at a concentration of 61 g/L with a yield of 71 % from glycerol (Morgunov et al. 2004; Finogenova et al. 2005).
Synthesis
Pyruvic acid's synthesis method is as follows: from Tartaric acid by heating with hydrophilic agents, such as Potassium hydrosulfate.
Purification Methods
Distil it twice, then fractionally crystallise it by partial freezing. [Beilstein 3 IV 1505.]
Pyruvic acid Preparation Products And Raw materials
Raw materials
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chevron_right| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| BTC pharm India | +918790379245 | AndhraPradesh, India | 1269 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| CHEMSWORTH | +91-261-2397244 | New Delhi, India | 6707 | 30 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Otto Chemie Pvt. Ltd. | +91 9820041841 | Mumbai, India | 5873 | 58 | Inquiry |
| Alfa Aesar | 1 800 209 7001 | Maharashtra, India | 6913 | 58 | Inquiry |
| Sisco Research Laboratories Pvt. Ltd. | +91-22-4268 5800 | Mumbai, India | 4317 | 58 | Inquiry |
| Triveni chemicals | 08048762458 | New Delhi, India | 6093 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| BTC pharm India | 58 |
| A.J Chemicals | 58 |
| CHEMSWORTH | 30 |
| CLEARSYNTH LABS LTD. | 58 |
| Otto Chemie Pvt. Ltd. | 58 |
| Alfa Aesar | 58 |
| Sisco Research Laboratories Pvt. Ltd. | 58 |
| Triveni chemicals | 58 |
| Pharmaffiliates Analytics and Synthetics P. Ltd | 58 |
| SynZeal Research Pvt Ltd | 58 |
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