3-Bromopyruvic acid
- CAS No.
- 1113-59-3
- Chemical Name:
- 3-Bromopyruvic acid
- Synonyms
- 3-bromopyruvate;3-BROMOPYRUVIC ACID;3-BROMO-2-OXOPROPANOIC ACID;bromopyruvate;BROMOPYRUVIC ACID;2-Oxo-3-bromopropanoic acid;3-BROMO-2-OXOPROPIONIC ACID;beta-bromopyruvicacid;NSC 62343;NSC 11731
- CBNumber:
- CB0380692
- Molecular Formula:
- C3H3BrO3
- Molecular Weight:
- 166.96
- MOL File:
- 1113-59-3.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/14 20:44:35
| Melting point | 77-82 °C |
|---|---|
| Boiling point | 223.4±23.0 °C(Predicted) |
| Density | 1.7314 (rough estimate) |
| refractive index | 1.4650 (estimate) |
| storage temp. | 2-8°C |
| solubility | water: soluble1g/10 mL, clear, colorless |
| form | White crystalline solid |
| pka | 1.84±0.54(Predicted) |
| color | White to Almost white |
| Water Solubility | Soluble in water, dimethyl sulfoxide, ethyl acetate and water. |
| BRN | 1746786 |
| InChIKey | PRRZDZJYSJLDBS-UHFFFAOYSA-N |
| CAS DataBase Reference | 1113-59-3(CAS DataBase Reference) |
| EPA Substance Registry System | Propanoic acid, 3-bromo-2-oxo- (1113-59-3) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H314 | |||||||||
| Precautionary statements | P260-P280-P301+P330+P331-P303+P361+P353-P304+P340+P310-P305+P351+P338 | |||||||||
| Hazard Codes | C | |||||||||
| Risk Statements | 34-20/21/22 | |||||||||
| Safety Statements | 26-36/37/39-45-27 | |||||||||
| RIDADR | UN 3261 8/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | UZ0840000 | |||||||||
| F | 19-21 | |||||||||
| Hazard Note | Corrosive | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29183000 | |||||||||
| NFPA 704 |
|
3-Bromopyruvic acid price More Price(10)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 16490 | Bromopyruvic acid ≥98.0% | 1113-59-3 | 10G | ₹8800.73 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 16490 | Bromopyruvic acid ≥98.0% | 1113-59-3 | 50G | ₹27105.8 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 16490 | Bromopyruvic acid ≥98.0% | 1113-59-3 | 500G | ₹157633.65 | 2022-06-14 | Buy |
| ALFA India | ALF-L00720-18 | Bromopyruvic acid, 97% | 1113-59-3 | 50g | ₹16447 | 2022-05-26 | Buy |
| TCI Chemicals (India) | B1153 | 3-Bromopyruvic Acid | 1113-59-3 | 5G | ₹7000 | 2022-05-26 | Buy |
3-Bromopyruvic acid Chemical Properties,Uses,Production
Chemical Properties
Off-white solid
Uses
Bromopyruvic Acid is a synthetic brominated derivative of pyruvic acid. Bromopyruvic Acid maybe a potential treatment for certain types of cancer as it has shown to be effective at eliminating aggress ive liver tumors.
Definition
ChEBI: 3-bromopyruvic acid is a 2-oxo monocarboxylic acid that is pyruvic acid in which one of the methyl hydrogens is replaced by bromine. Synthetic brominated derivative and structural analog of pyruvic acid. Highly reactive alkylating agent. Anti-cancer drug It has a role as an alkylating agent and an antineoplastic agent. It is a 2-oxo monocarboxylic acid and an organobromine compound. It derives from a pyruvic acid. It is a conjugate acid of a 3-bromopyruvate.
Preparation
Synthesis method of 3-bromopyruvic acid: add a little concentrated sulfuric acid and solvent dichloromethane to pyruvic acid in a reaction flask, add bromine dropwise for about 3.5h and stir, a white precipitate is produced, then continue to stir for 1h, dilute with cyclohexane and petroleum ether, then cool the reaction mixture to get crystals, filter, wash with petroleum ether and dry to get the finished product of 3-bromopyruvic acid.
General Description
Bromopyruvic acid is an affinity label for cysteine residues?. It acts as cross-linker between nucleic acids and proteins. Kinetics of inactivation of pancreatic ribonuclease A by bromopyruvic acid has been investigated.
Purification Methods
Dry it by azeotropic distillation (with toluene), and then recrystallise it from dry CHCl3. Dry for 48hours at 20o (0.5 torr) over P2O5. Store it at 0o. [Labandiniere et al. J Org Chem 52 157 1987, Beilstein 3 III 1167.]
3-Bromopyruvic acid Preparation Products And Raw materials
Raw materials
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| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Otto Chemie Pvt. Ltd. | +91 9820041841 | Mumbai, India | 5873 | 58 | Inquiry |
| Alfa Aesar | 1 800 209 7001 | Maharashtra, India | 6913 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| Suzhou Actchem Co., Ltd. | +8618762124502 | China | 27 | 58 | Inquiry |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-81148696 +8615536356810 | China | 1384 | 58 | Inquiry |
| Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | China | 12460 | 58 | Inquiry |
| Hebei Duling International Trade Co. LTD | +8617333973358 | China | 15437 | 58 | Inquiry |
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