Lactic acid
- CAS No.
- 50-21-5
- Chemical Name:
- Lactic acid
- Synonyms
- 2-Hydroxypropanoic acid;DL-Lactic acid;Lactic;2-HYDROXYPROPIONIC ACID;dl-lactate;Purac;actic acid;LACTIC ACID POWDER;Biolac;FEMA 2611
- CBNumber:
- CB8193447
- Molecular Formula:
- C3H6O3
- Molecular Weight:
- 90.08
- MOL File:
- 50-21-5.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/14 20:44:35
| Melting point | 18°C |
|---|---|
| alpha | -0.05 º (c= neat 25 ºC) |
| Boiling point | 122 °C/15 mmHg (lit.) |
| Density | 1.209 g/mL at 25 °C (lit.) |
| vapor density | 0.62 (vs air) |
| vapor pressure | 19 mm of Hg (@ 20°C) |
| refractive index |
n |
| FEMA | 2611 | LACTIC ACID |
| Flash point | >230 °F |
| storage temp. | 2-8°C |
| solubility | Miscible with water and with ethanol (96 per cent). |
| pka | 3.08(at 100℃) |
| form | syrup |
| color | Colorless to yellow |
| Specific Gravity | 1.209 |
| PH | 3.51(1 mM solution);2.96(10 mM solution);2.44(100 mM solution); |
| Odor | at 100.00 %. odorless |
| Odor Type | odorless |
| Water Solubility | SOLUBLE |
| Merck | 14,5336 |
| JECFA Number | 930 |
| BRN | 1209341 |
| Dielectric constant | 22.0（16℃） |
| Stability | Stable. Combustible. Incompatible with strong oxidizing agents. |
| InChIKey | JVTAAEKCZFNVCJ-UHFFFAOYSA-N |
| LogP | -0.72 |
| CAS DataBase Reference | 50-21-5(CAS DataBase Reference) |
| NIST Chemistry Reference | Propanoic acid, 2-hydroxy-(50-21-5) |
| EPA Substance Registry System | Lactic acid (50-21-5) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H315-H318 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P305+P351+P338-P332+P313-P362+P364 | |||||||||
| Hazard Codes | Xi,C | |||||||||
| Risk Statements | 38-41-34-37/38 | |||||||||
| Safety Statements | 26-39-45-36/37/39 | |||||||||
| RIDADR | 3265 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | OD2800000 | |||||||||
| F | 3 | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29181100 | |||||||||
| NFPA 704 |
|
Lactic acid price More Price(31)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | W261114 | Lactic acid natural, ≥85% | 50-21-5 | 1SAMPLE-K | ₹5347.55 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | W261106 | Lactic acid 85%, FCC | 50-21-5 | 1SAMPLE-K | ₹5141.88 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | W261114 | Lactic acid natural, ≥85% | 50-21-5 | 1KG | ₹7241.93 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | W261106 | Lactic acid 85%, FCC | 50-21-5 | 1KG | ₹6971.3 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | W261106 | Lactic acid 85%, FCC | 50-21-5 | 25KG | ₹35397.75 | 2022-06-14 | Buy |
Lactic acid Chemical Properties,Uses,Production
Chemical Properties
Lactic acid, CH3CHOHCOOH, also known as 2-hydroxypropanoic acid, is a hygroscopic liquid that exists in three isometric forms. I-lactic acid is found in blood and animal tissue as a product of glucose and glycogen metabolism. d-Iactic acid is obtained by fermentation of sucrose (corn refining), The racemic mixture is present in foods prepared by bacterial fermentation or prepared synthetically. Lactic acid is soluble in water,alcohol,and ether. It is used as a solvent, in manufacturing confectionery, and in medicine.
Occurrence
Reported found in Papaver somniferum L.; it is a constituent of wine and sour milk; the two optically active isomers are found in muscular tissues and are formed by the action of lactic acid–producing bacteria in several fermentation processes. Also reported found in guava, grapes, melon, wheat bread, cheeses, yogurt, milk, cream, buttermilk, egg, cooked beef, cognac, cider, sherry, grape wine, beer, grape brandy, whiskey, cocoa, coffee, tea, mango, sake, wort, dried, bonito, cassava, Bourbon vanilla, chicory root, Cape gooseberry and cherimoya.
Uses
lactic acid (sodium lactate) is a multi-purpose ingredient used as a preservative, exfoliant, moisturizer, and to provide acidity to a formulation. In the body, lactic acid is found in the blood and muscle tissue as a product of the metabolism of glucose and glycogen. It is also a component of the skin’s natural moisturizing factor. Lactic acid has better water intake than glycerin. Studies indicate an ability to increase the water-retention capacity of the stratum corneum. They also show that the pliability of the stratum corneum layer is closely related to the absorption of lactic acid; that is, the greater the amount of absorbed lactic acid, the more pliable the stratum corneum layer. Researchers report that continuous use of preparations formulated with lactic acid in concentrations ranging between 5 and 12 percent provided a mild to moderate improvement in fine wrinkling and promote softer, smoother skin. Its exfoliating properties can help in the process of removing excess pigment from the surface of the skin, as well as improving skin texture and feel. Lactic acid is an alpha hydroxy acid occurring in sour milk and other lesser-known sources, such as beer, pickles, and foods made through a process of bacterial fermentation. It is caustic when applied to the skin in highly concentrated solutions.
Production Methods
Lactic acid is prepared by the fermentation of carbohydrates, such
as glucose, sucrose, and lactose, with Bacillus acidi lacti or related
microorganisms. On a commercial scale, whey, corn starch,
potatoes, or molasses are used as a source of carbohydrate. Lactic
acid may also be prepared synthetically by the reaction between
acetaldehyde and carbon monoxide at 130–200°C under high
pressure, or by the hydrolysis of hexoses with sodium hydroxide.
Lactic acid prepared by the fermentation of sugars is levorotatory;
lactic acid prepared synthetically is racemic. However, lactic
acid prepared by fermentation becomes dextrorotatory on dilution
with water owing to the hydrolysis of (R)-lactic acid lactate to (S)-
lactic acid.
Definition
ChEBI: A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
General Description
A colorless to yellow odorless syrupy liquid. Corrosive to metals and tissue. Used to make cultured dairy products, as a food preservative, and to make chemicals.
Air & Water Reactions
Soluble in water.
Health Hazard
Inhalation of mist causes coughing and irritation of mucous membranes. Ingestion, even of diluted preparations, has a corrosive effect on the esophagus and stomach. Contact with more concentrated solutions can cause severe burns of skin or eye.
Fire Hazard
Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form.
Pharmaceutical Applications
Lactic acid is used in beverages, foods, cosmetics, and pharmaceuticals
as an acidifying agent and acidulant.
In topical formulations, particularly cosmetics, it is used for its
softening and conditioning effect on the skin. Lactic acid may also
be used in the production of biodegradable polymers and microspheres,
such as poly(D-lactic acid), used in drug delivery
systems.
Lactic acid is also used as a food preservative. Therapeutically,
lactic acid is used in injections, in the form of lactate, as a source of
bicarbonate for the treatment of metabolic acidosis; as a spermicidal
agent; in pessaries for the treatment of leukorrhea; in infant feeds;
and in topical formulations for the treatment of warts.
Industrial uses
lactic acid showed good depressing effect on hornblende, pyroxene and biotite during flotation of hematite and ilmenite minerals.
Safety
Lactic acid occurs in appreciable quantities in the body as an end
product of the anaerobic metabolism of carbohydrates and, while
harmful in the concentrated form , can be
considered nontoxic at the levels at which it is used as an excipient.
A 1% v/v solution, for example, is harmless when applied to the
skin.
There is evidence that neonates have difficulty in metabolizing
(R)-lactic acid, and this isomer and the racemate should therefore
not be used in foods intended for infants aged less than 3 months
old.
There is no evidence that lactic acid is carcinogenic, teratogenic,
or mutagenic.
LD50 (guinea pig, oral): 1.81 g/kg
LD50 (mouse, oral): 4.88 g/kg
LD50 (mouse, SC): 4.5 g/kg
LD50 (rat, oral): 3.73 g/kg
storage
Lactic acid is hygroscopic and will form condensation products
such as polylactic acids on contact with water. The equilibrium
between the polylactic acids and lactic acid is dependent on
concentration and temperature. At elevated temperatures lactic acid
will form lactide, which is readily hydrolyzed back to lactic acid.
Lactic acid should be stored in a well-closed container in a cool,
dry place.
Incompatibilities
Incompatible with oxidizing agents, iodides, and albumin. Reacts violently with hydrofluoric acid and nitric acid.
Regulatory Status
GRAS listed. Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (IM, IV, and SC injections; oral syrups and tablets; topical and vaginal preparations). Included in medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.
Lactic acid Preparation Products And Raw materials
Raw materials
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chevron_right| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Vardhaman P Golechha | 9704422000 | Telangana, India | 294 | 58 | Inquiry |
| Jiaan Biotech | +91-8349999795 +91-9039039794 | Madhya Pradesh, India | 13 | 58 | Inquiry |
| Enzyme BioScience pvt Ltd | +91-9722913685 +91-8690076795 | Gujarat, India | 25 | 58 | Inquiry |
| Prakash Chemicals Agencies | +91-8511140657 | Gujarat, India | 106 | 58 | Inquiry |
| UNILOSA INTERNATINAL PRIVATE LIMITED | +91-9999069917 +91-9999069917 | New Delhi, India | 152 | 58 | Inquiry |
| JSK Chemicals | +919879767970 | Gujarat, India | 3756 | 58 | Inquiry |
| BASF India Limited | +91-2262785600 +91-2262785600 | Maharashtra, India | 209 | 58 | Inquiry |
| HRV Global Life Sciences | +91-9820219686 +91-9820219686 | Telangana, India | 379 | 58 | Inquiry |
| Merck Ltd | +91-2262109800 +91-2262109000 | Maharashtra, India | 272 | 58 | Inquiry |
| Prathista Industries Limited | +91-9618055642 +91-7032888081 | Telangana, India | 11 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Vardhaman P Golechha | 58 |
| Jiaan Biotech | 58 |
| Enzyme BioScience pvt Ltd | 58 |
| Prakash Chemicals Agencies | 58 |
| UNILOSA INTERNATINAL PRIVATE LIMITED | 58 |
| JSK Chemicals | 58 |
| BASF India Limited | 58 |
| HRV Global Life Sciences | 58 |
| Merck Ltd | 58 |
| Prathista Industries Limited | 58 |
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