IBOTENIC ACID
- CAS No.
- 2552-55-8
- Chemical Name:
- IBOTENIC ACID
- Synonyms
- IBOTENIC ACID;IBOTENIC ACID(RG);DL-Ibotenic acid.;(RS)-Ibotenic acid;(+/-)-IBOTENIC ACID;Ibotenic Acid (CRM);IBOTENIC ACID USP/EP/BP;Ibotenic Acid [(RS)-Ibotenic acid;α-amino-3-hydroxy-5-isoxazoleacetic acid;2-amino-2-(3-ketoisoxazol-5-yl)acetic acid
- CBNumber:
- CB0400501
- Molecular Formula:
- C5H6N2O4
- Molecular Weight:
- 158.11
- MOL File:
- 2552-55-8.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/6/26 9:58:26
| Melting point | 141-147 °C |
|---|---|
| Density | 1.621±0.06 g/cm3 (20 ºC 760 Torr) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | H2O: soluble1mg/mL, clear, colorless (with sonication) |
| form | White solid |
| pka | 2.16±0.10(Predicted) |
| color | white |
| Odor | Practically odorless. Faint, meat-like, mild and sweet taste in aqueous dilutions. |
| Water Solubility | Soluble to 10 mM in water and to 100 mM in 1.1eq. NaOH |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 1 month. |
| InChIKey | IRJCBFDCFXCWGO-UHFFFAOYSA-N |
| LogP | -1.070 (est) |
| CAS DataBase Reference | 2552-55-8(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301 | |||||||||
| Precautionary statements | P264-P270-P301+P310-P405-P501 | |||||||||
| Hazard Codes | T,Xn | |||||||||
| Risk Statements | 23/24/25-25-40 | |||||||||
| Safety Statements | 45-38-36/37/39-28A-22-36 | |||||||||
| RIDADR | 1544 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | NY2100000 | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | III | |||||||||
| Toxicity | LD50 in mice, rats (mg/kg): 15, 42 i.v.; 38, 129 orally (Theobald) | |||||||||
| NFPA 704 |
|
IBOTENIC ACID price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | I2765 | Ibotenic acid ~95%, solid | 2552-55-8 | 1MG | ₹21880 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | I2765 | Ibotenic acid ~95%, solid | 2552-55-8 | 5MG | ₹65350 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | I2765 | Ibotenic acid ~95%, solid | 2552-55-8 | 10MG | ₹123750 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | I2765 | Ibotenic acid ~95%, solid | 2552-55-8 | 25MG | ₹236030 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 5.05024 | Ibotenic Acid - CAS 2552-55-8 - Calbiochem | 2552-55-8 | 1MG | ₹14100 | 2022-06-14 | Buy |
IBOTENIC ACID Chemical Properties,Uses,Production
Chemical Properties
Crystalline solid; forms monohydrate; mp151°C (303.8°F) (anhydrous), 145°C (293°F)(monohydrate); soluble in water and alcohol.
Uses
Ibotenic acid is a neuroexcitatory amino acid originally isolated from Amanita species that functions as a NMDA and metabotropic glutamate receptor agonist. As a neurotoxin, ibotenic acid is often used to induce brain lesions in animals that model cognitive dysfunctions resulting from neurodegenerative diseases, traumatic brain injury, and stroke.
Definition
A isoxazole which, together with muscimol, is largely responsible for the toxicities of a number of mushrooms including those of the genus Amanita. It is a potent excitatory amino acid.
Preparation
Isolated from the Japanese fly mushroom. The acid can be produced synthetically.
Hazard
Neurotoxic; causes motor depression, ataxia, changes in mood, perceptions and feelings.
Health Hazard
Ibotenic acid is a potent neurologic aminoacid. It exhibits neuroexcitatory activity andcauses sedative actions on spinal neurons.High doses can cause sleep, hallucinations,distorted perceptions, and nausea. In humansthe symptoms above may be manifested fromingestion of 6–8 mg of ibotenic acid.
LD50 value, oral (mice): 38 mg/kg
LD50 value, intraperitoneal (mice): 15 mg/kg.
Biological Activity
NMDA and metabotropic glutamate receptor agonist.
Purification Methods
It has been converted to the ammonium salt (m 121-123o dec) dissolved in H2O, passed through an Amberlite IR 120 resin (H+ form) and eluted with H2O. The acidic fractions are collected, evaporated to dryness and the residue recrystallises from H2O as the monohydrate (m 144-146o). The anhydrous acid is obtained by making a slurry with MeOH, decanting and evaporating to dryness, and repeating the process twice more to give the anhydrous acid (m 151-152o). Recrystallisation from H2O gives the monohydrate. [Nakamura Chem Pharm Bull Jpn 19 46 1971.] The ethyl ester forms needles when crystallised from a small volume of Et2O and has m 78-79o and IR (CHCl3) with max 35002300 (OH), 1742 (ester C=O), 1628, 1528cm-1, and UV with λmax (EtOH) at 206nm (ε 7,080). The hydrazide has m 174-175o (from MeOH) with IR (KBr) 1656 (C=O)cm-1.
IBOTENIC ACID Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| SRI ANAGHA BIOSCIENCES PVT LTD | +91-9959644262 +91-9959644262 | Telangana, India | 25 | 58 | Inquiry |
| Neugen Labs | +91-8133254502 +91-8133254502 | Karnataka, India | 195 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| ARCTIC EXPORTS INC | +1-3026880818 +1-3026880818 | Canada | 68 | 58 | Inquiry |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | China | 20308 | 58 | Inquiry |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32760 | 60 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29898 | 58 | Inquiry |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | China | 39916 | 58 | Inquiry |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | China | 9030 | 58 | Inquiry |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | China | 10522 | 58 | Inquiry |
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