L-AP4
- CAS No.
- 23052-81-5
- Chemical Name:
- L-AP4
- Synonyms
- GDF5;L-AP4;L-APB;SYNS2;CDMP1;GDF-5 human;GDF-5 mouse;BMP-14/ CDMP-1;BMP-14 (GDF-5/CDMP-1) human;2-ammonio-4-phosphonatobutanoate
- CBNumber:
- CB1141944
- Molecular Formula:
- C4H10NO5P
- Molecular Weight:
- 183.1
- MOL File:
- 23052-81-5.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/6/30 15:45:59
| Melting point | 207-215 °C |
|---|---|
| Boiling point | 491.7±55.0 °C(Predicted) |
| Density | 1.628±0.06 g/cm3(Predicted) |
| storage temp. | 0-6°C |
| solubility | H2O : 50 mg/mL (273.07 mM; Need ultrasonic) |
| pka | 2.19±0.10(Predicted) |
| form | solid |
| color | White |
| Water Solubility | Soluble to 5 mM in water and to 100 mM in 1eq. NaOH |
| Sensitive | Light Sensitive |
| CAS DataBase Reference | 23052-81-5(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | ES7191700 | |||||||||
| NFPA 704 |
|
L-AP4 price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | A7929 | L-(+)-2-Amino-4-phosphonobutyric acid optical purity optical purity: ≥95% (HPLC, Marfey′s reagent) | 23052-81-5 | 0.5MG | ₹8440 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | SRP4667 | GDF-5 human recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC) | 23052-81-5 | 50μG | ₹30483.2 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | A7929 | L-(+)-2-Amino-4-phosphonobutyric acid optical purity optical purity: ≥95% (HPLC, Marfey′s reagent) | 23052-81-5 | 1MG | ₹14020 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 165300 | L-(+)-2-Amino-4-phosphonobutyric Acid - CAS 23052-81-5 - Calbiochem | 23052-81-5 | 1MG | ₹10550.01 | 2022-06-14 | Buy |
| ALFA India | ALF-J64075-MCR | (S)-(+)-2-Amino-4-phosphonobutyric acid, 97% | 23052-81-5 | 1mg | ₹5569 | 2022-05-26 | Buy |
L-AP4 Chemical Properties,Uses,Production
Description
Metabotropic glutamate receptors (mGluR) function to modulate excitatory synaptic transmission in the brain. Eight subtypes (1-
Chemical Properties
white to off-white crystalline powder
Uses
Metabotropic glutamate receptors (mGluR) function to modulate excitatory synaptic transmission in the brain. Eight subtypes (1-8) and multiple splice variants of the mGluR have been identified and grouped based on their pharmacological properties. Group I mGluRs (subtypes 1 and 5) activate the phosphatidyl inositol pathway, while Group II (2 and 3) and Group III (4, 6, 7, and 8) inhibit adenylyl cyclase. L-AP4, an analog of L-glutamic acid, is a selective Group III mGluR agonist that functions presynaptically to suppress glutamate release (IC50 = 2.5 μM). L-AP4 has been shown to depress synaptic transmission in glutamatergic pathways in the hippocampus, olfactory bulb, and retina as well as act as an agonist at the quisqualate-sensitized AP6 site in hippocampus.
Biological Activity
Selective group III metabotropic glutamate receptor agonist. Synaptic depressant. Agonist at the quisqualate-sensitized AP6 site in hippocampus. Also available as part of the Group III mGlu Receptor Tocriset™ and Mixed mGlu Receptor Tocriset™ .
L-AP4 Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Alfa Aesar | 1 800 209 7001 | Maharashtra, India | 6913 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29826 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
| Nextpeptide Inc | +86-0571-81612335 +8613336028439 | China | 19915 | 58 | Inquiry |
| Aladdin Scientific | +1-+1(833)-552-7181 | United States | 57511 | 58 | Inquiry |
| Aladdin Scientific | +1-+1(833)-552-7181 | United States | 52927 | 58 | Inquiry |
| Amadis Chemical Company Limited | 571-89925085 | China | 131980 | 58 | Inquiry |
| Shanghai Yaoyun Biological Technology Co., Ltd. | 400-002-6926 400-002-6926 | CHINA | 6852 | 58 | Inquiry |
| Morning Student Science and Technology (Guangzhou) Co., Ltd. | 020-36048871 13760856740 | CHINA | 6618 | 58 | Inquiry |
| Shanghai Jijin Chemical Technology Co., Ltd. | 400-002-6926 15900443528 | CHINA | 6617 | 58 | Inquiry |
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