L-AP4
L-AP4
- CAS:
- 23052-81-5
- MF:
- C4H10NO5P
- MW:
- 183.1
Suppliers by country/region
Company Type
Properties
- Melting point:
- 207-215 °C
- Boiling point:
- 491.7±55.0 °C(Predicted)
- Density
- 1.628±0.06 g/cm3(Predicted)
- storage temp.
- 0-6°C
- solubility
- H2O : 50 mg/mL (273.07 mM; Need ultrasonic)
- form
- solid
- pka
- 2.19±0.10(Predicted)
- color
- White
- Water Solubility
- Soluble to 5 mM in water and to 100 mM in 1eq. NaOH
- Sensitive
- Light Sensitive
Safety Information
- Symbol(GHS)
GHS07
- Signal word
- Warning
- Hazard statements
- H315-H319-H335
- Precautionary statements
- P261-P280a-P304+P340-P305+P351+P338-P405-P501a
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36
- WGK Germany
- 3
- RTECS
- ES7191700
Use
Metabotropic glutamate receptors (mGluR) function to modulate excitatory synaptic transmission in the brain. Eight subtypes (1-8) and multiple splice variants of the mGluR have been identified and grouped based on their pharmacological properties. Group I mGluRs (subtypes 1 and 5) activate the phosphatidyl inositol pathway, while Group II (2 and 3) and Group III (4, 6, 7, and 8) inhibit adenylyl cyclase. L-AP4, an analog of L-glutamic acid, is a selective Group III mGluR agonist that functions presynaptically to suppress glutamate release (IC50 = 2.5 μM). L-AP4 has been shown to depress synaptic transmission in glutamatergic pathways in the hippocampus, olfactory bulb, and retina as well as act as an agonist at the quisqualate-sensitized AP6 site in hippocampus.
0 India supplier list of "L-AP4"
- Product Name:L-(+)-2-Amino-4-phosphonobutyricacid
- Products Intro:Brand:sigma aldrich | Product Number:A7929 | Purity:opticalpurityopticalpurity:≥95%(HPLC,Marfey′sreagent)
- Company Type: Trader
- Country/Region: Bangalore,INDIA
- Product Name:(2S)-2-amino-4-phosphonobutanoicacid
- Products Intro:Brand:thermofisher.in | Product Number:ALF-J64075-MA | Purity:99%
- Company Type: Trader
- Country/Region: Maharashtra,INDIA
- Product Name:L-AP4
- Products Intro:Purity: 95--99% | Package: 1KG;1USD
- Company Type: Trader
- Country/Region: CHINA
$1.00/ 1KG
- Product Name:L-AP4
- Products Intro:Purity: >=99% | Package: $76.9/1mg;$91.9/5mg;$166.9/10mg;Bulk package | CustNote: 99%
- Company Type: Trader
- Country/Region: UNITED STATES
- Main Products: Chemicals and BioChemicals,Materials Science,ligands acting on targets,Proteins,Antibodies
- Product Name:L-AP4
- Products Intro:Purity: >=99% | Package: $200.9/ml;$690.9/ml;Bulk package | CustNote: 99%
- Company Type: Trader
- Country/Region: UNITED STATES
- Main Products: Chemicals and BioChemicals,Materials Science,ligands acting on targets,Proteins,Antibodies
- Product Name:2-ammonio-4-phosphonatobutanoate
- Products Intro:Purity: 0.97 | Package: mgs,gs,kgs | CustNote: A816529
- Company Type: Reagent
- Country/Region: CHINA
-
1mg$75.20
- Product Name:L-(+)-2-Amino-4-phosphonobutyric Acid - CAS 23052-81-5 - Calbiochem
- Products Intro:Brand: Sigma-Aldrich | Product Number: 165300
- Company Type: Trader
- Country/Region: UNITED STATES
- Main Products: cof,mof
-
10mg$214.00
- Product Name:(S)-(+)-2-Amino-4-phosphonobutyricacid
- Products Intro:Brand：Alfa Aesar | Product Number：J64075 | Purity：97%
- Company Type: Trader
- Country/Region: UNITED STATES
-
1 mg$40.005 mg$80.0010 mg$140.0050 mg$600.00
- Product Name:L-AP4
- Products Intro:Brand: Caymanchem | Product Number: 14538 | Purity: ≥99%
- Company Type: Trader
- Country/Region: UNITED STATES
- Main Products: cof,mof
-
1 mg$89.0010 mg$195.0050 mg$819.00
- Product Name:L-(+)-2-Amino-4-phosphonobutyric acid
- Products Intro:Brand: Tocris Bioscience | Product Number: 0103 | Purity: ≥99% (HPLC)
- Company Type: Trader
- Country/Region: UNITED KINGDOM
- Main Products: cof,mof