BIS(P-TOLYL)PHOSPHINE OXIDE
- CAS No.
- 2409-61-2
- Chemical Name:
- BIS(P-TOLYL)PHOSPHINE OXIDE
- Synonyms
- Bis(p-toL;Di-p-tolylphosphine oxide;BIS(P-TOLYL)PHOSPHINE OXIDE;Di(p-tolyl)phosphineOxide>bis(4-methylphenyl)-oxophosphanium;Bis(4-Methylphenyl)phosphine Oxide;Bis (p-Methylphenyl) phosphine oxide;Phosphine oxide, bis(4-methylphenyl)-;1-Methyl-4-[(4-Methylphenyl)phosphoryl]benzene
- CBNumber:
- CB0448246
- Molecular Formula:
- C14H15OP
- Molecular Weight:
- 230.24
- MOL File:
- 2409-61-2.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/30 11:11:41
| Melting point | 96°C(lit.) |
|---|---|
| Boiling point | 354.2±45.0 °C(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| form | powder to crystal |
| color | White to Almost white |
| Water Solubility | Slightly soluble in water. |
| InChI | InChI=1S/C14H15OP/c1-11-3-7-13(8-4-11)16(15)14-9-5-12(2)6-10-14/h3-10,16H,1-2H3 |
| InChIKey | GCUWBTGMXUIKOB-UHFFFAOYSA-N |
| SMILES | P(=O)(C1=CC=C(C)C=C1)C1=CC=C(C)C=C1 |
| CAS DataBase Reference | 2409-61-2 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Risk Statements | 20/21/22 | |||||||||
| Safety Statements | 26-36/37/39 | |||||||||
| HS Code | 29319090 | |||||||||
| NFPA 704 |
|
BIS(P-TOLYL)PHOSPHINE OXIDE price More Price(2)
BIS(P-TOLYL)PHOSPHINE OXIDE Chemical Properties,Uses,Production
Chemical Properties
White powder
Uses
Bis(p-tolyl)phosphine oxide is used as an organic chemical synthesis intermediate.
Synthesis Reference(s)
[1] Controllable Phosphorylation of Thioesters: Selective Synthesis of Aryl and Benzyl Phosphoryl Compounds. J. Org. Chem. 2020, 85, 22, 14653–14663.
Synthesis
A dried 250 mL flask was charge with p-tolylmagnesium bromide (33 mmol, 1.0 mol/L in THF) in an ice-water bath under N2. A solution of diethylphosphite (1.3 mL, 10.0 mmol) in anhydrous THF (5.0 mL) was then added dropwise over 30 min. The mixture was further stirred at ambient temperature overnight. After that, the reaction mixture was cooled to 0 °C again, and HCl (100 mL 0.1 N) was added dropwise. The mixture was extracted with dichloromethane (100 mL × 3), and the combined organic phase was washed with saturated NaCl solution, dried over anhydrous MgSO4, filtered, and concentrated in vacuo. The crude product was purified by column chromatography (EtOAc) to give the desired product BIS(P-TOLYL)PHOSPHINE OXIDE.
BIS(P-TOLYL)PHOSPHINE OXIDE Preparation Products And Raw materials
Raw materials
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