Baloxavir
- CAS No.
- 1985605-59-1
- Chemical Name:
- Baloxavir
- Synonyms
- (R)-12-((S)-7,8-difluoro-6,11-dihydrodibenzo[b,e]thiepin-11-yl)-7-hydroxy-3,4,12,12a-tetrahydro-1H-[1,4]oxazino[3,4-c]pyrido[2,1-f][1,2,4]triazine-6,8-dione;S-033447;CPD2051;Baloxavir;New Baloxavir;Baloxavir (Xofluza;Baloxavir USP/EP/BP;Baloxavir Impurity 10;BXA,endonuclease,S033447,Influenza Virus;influenza,RNA,inhibit,dolutegravir,Baloxavir,Inhibitor,cap-dependent,S 033447,CEN,transcription,replication
- CBNumber:
- CB04662930
- Molecular Formula:
- C24H19F2N3O4S
- Molecular Weight:
- 483.49
- MOL File:
- 1985605-59-1.mol
- Modify Date:
- 2024/7/2 8:54:58
| Boiling point | 644.7±65.0 °C(Predicted) |
|---|---|
| Density | 1.63±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO:41.67(Max Conc. mg/mL);86.19(Max Conc. mM) |
| form | A solid |
| pka | 4.50±1.00(Predicted) |
| color | White to yellow |
| CAS DataBase Reference | 1985605-59-1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| NFPA 704 |
|
Baloxavir Chemical Properties,Uses,Production
Uses
Baloxavir is a drug employed in the treatment of influenza virus infection.
Mechanism of action
Baloxavir marboxil is an influenza therapeutic agent, specifically, an enzyme inhibitor targeting the influenza virus' cap-dependent endonuclease activity, one of the activities of the virus polymerase complex. In particular, it inhibits a process known as cap snatching, by which the virus derives short, capped primers from host cell RNA transcripts, which it then uses for polymerase-catalyzed synthesis of its needed viral mRNAs. A polymerase subunit binds to the host pre-mRNAs at their 5' caps, then the polymerase's endonuclease activity catalyzes its cleavage "after 10–13 nucleotides". As such, its mechanism is distinct from neuraminidase inhibitors such as oseltamivir and zanamivir.
Side effects
Common side effects following the single dose administration of baloxavir marboxil include diarrhea, bronchitis, common cold, headache, and nausea. Adverse events were reported in 21% of people who received baloxavir, 25% of those receiving placebo, and 25% of oseltamivir.
Baloxavir Preparation Products And Raw materials
Raw materials
Preparation Products
Baloxavir Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Bulat Pharmaceutical Pvt Ltd | +91-8448085659 +91-8448085660 | Haryana, India | 123 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Heading （Nanjing）Pharmtechnologies Co., Ltd. | +86-25-58467899-832 +86-13382406280 | China | 46 | 58 | Inquiry |
| Shaanxi TNJONE Pharmaceutical Co., Ltd | +8618740459177 | China | 1142 | 58 | Inquiry |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | China | 9336 | 55 | Inquiry |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32760 | 60 | Inquiry |
| BOC Sciences | +1-631-485-4226 | United States | 19553 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29825 | 58 | Inquiry |
| Xi'an Yutbon Pharmaceutical Technology Co., Ltd | 029-81140587 +8618717328141 | China | 453 | 58 | Inquiry |
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | China | 12452 | 58 | Inquiry |
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