4-(3'-Methylphenyl)amino-3-pyridinesulfonamide
- CAS No.
- 72811-73-5
- Chemical Name:
- 4-(3'-Methylphenyl)amino-3-pyridinesulfonamide
- Synonyms
- BM 960102;Torsemide Imp B;TORSEMIDE EP IMP B;4-(3'-Methylphenyl)a;TorseMide IMpurity B;SPECS AJ-333/25006115;Torasemide intermediate;Torsemide EP Impurity B;Torasemide EP Impurity B;Torasemide impurity B (EP)
- CBNumber:
- CB0486466
- Molecular Formula:
- C12H13N3O2S
- Molecular Weight:
- 263.32
- MOL File:
- 72811-73-5.mol
- Modify Date:
- 2025/3/6 8:32:39
| Melting point | 162-164?C |
|---|---|
| Boiling point | 475.8±55.0 °C(Predicted) |
| Density | 1.357±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| pka | 9.53±0.60(Predicted) |
| color | White to Off-White |
| BRN | 5438165 |
| InChIKey | ZXPCUGWAKUIOOF-UHFFFAOYSA-N |
| CAS DataBase Reference | 72811-73-5(CAS DataBase Reference) |
4-(3'-Methylphenyl)amino-3-pyridinesulfonamide price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | PHR3145 | Torsemide Related Compound A pharmaceutical secondary standard, certified reference material | 72811-73-5 | 150MG | ₹49253.75 | 2022-06-14 | Buy |
| TCI Chemicals (India) | T3007 | 4-(m-Tolylamino)pyridine-3-sulfonamide | 72811-73-5 | 5G | ₹9700 | 2022-05-26 | Buy |
| TCI Chemicals (India) | T3007 | 4-(m-Tolylamino)pyridine-3-sulfonamide | 72811-73-5 | 25G | ₹25900 | 2022-05-26 | Buy |
4-(3'-Methylphenyl)amino-3-pyridinesulfonamide Chemical Properties,Uses,Production
Chemical Properties
White to Off-White Solid
Uses
Torasemide intermediate.
Synthesis
4-(3'-Methylphenyl)amino-3-pyridinesulfonamide is prepared by the reaction of 4-Chloropyridine-3-sulfonamide hydrochloride and 3-Methylaniline. The specific synthesis steps are as follows:
EXAMPLE 1; Preparation of 4-(3-methylphenyl)aminopyridine-sulfonamide; 2L three-neck flask, equipped with a mechanical stirrer, thermometer and condenser, was charged with water (500 ml) and 4-chloro-3- pyridinesulfonamide hydrochloride (100g, 0.44 mol). To this suspension was added m-toluidine (49.2 ml, 0.46 mol) at room temperature. The reaction mixture was heated to 90°C for a minimum period of 3 h. The progress of the reaction was followed by HPLC. After completion, the mixture was cooled to room temperature. The pH of the reaction was then adjusted carefully to pH 7-8 with sat. NaHC03 (ca. 1.1 l). The product was precipitated out and isolated by vacuum filtration as beige solid (126.2 g wet weight). The product was then dissolved in MeOH (1.0 l) at room temperature and charged with Darco KB (25g). The solution was refluxed for 0.5 h and then filtered through a patch of celite to remove Darco KB, while still hot, and rinsed with hot MeOH (200 ML). The filtrate was then charged with water (1.2 l) and stirred for a minimum of 1 h at room temperature. The product, which had precipitated out, was isolated by vacuum filtration to obtain a solid 106.3 g (92percent wet weight =>99.8percent purity a/a). 1H NMR (d6-DMSO) ; 2.30 (s, 3H), 7.00-7. 15 (m. 5H), 7.32 (m, 1H), 7.75 (brs, 1.5H), 8.05 (brs, 0.5H), 8.25 (d, 1H), 8.68 (s, 1H).
4-(3'-Methylphenyl)amino-3-pyridinesulfonamide Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Terma Medicare India Pvt.,Ltd | +86-53530655; +8613916485955 | Shanghai, India | 184 | 58 | Inquiry |
| Clickchem Research LLP | +91-8140031133 +91-8140031133 | Gujarat, India | 411 | 58 | Inquiry |
| Mekanar Pharma Private Limited | +91-9154988357 +91-9948050784 | Hyderabad, India | 29 | 58 | Inquiry |
| Synthetic Research Pharma Laboratories Pvt Ltd | +91 9848023377 | Hyderabad, India | 116 | 58 | Inquiry |
| AnalyticsStanza Inc | +91-7032031309 +91-7032031309 | Hyderabad, India | 226 | 58 | Inquiry |
| Prudence Pharma Chem | +91-9624042444 +91-9825205460 | Gujarat, India | 32 | 58 | Inquiry |
| Maithili Life Sciences Pvt Ltd | +91-9949816141 +91-9963263336 | Telangana, India | 33 | 58 | Inquiry |
| Shreepati Pharmaceuticals Pvt Ltd | +91-7312432706 +91-7312532647 | Madhya Pradesh, India | 7 | 58 | Inquiry |
| Medilux Laboratories Pvt Ltd | +91-7292409991 +91-9819666688 | Madhya Pradesh, India | 102 | 58 | Inquiry |
| MAISURIYA PHARMA SOLUTIONS | +91 9870085570 | Gujarat, India | 65 | 58 | Inquiry |
72811-73-5(4-(3'-Methylphenyl)amino-3-pyridinesulfonamide)Related Search:
1of4
chevron_right