Torasemide
- CAS No.
- 56211-40-6
- Chemical Name:
- Torasemide
- Synonyms
- TORSEMIDE;DEMADEX;Unat;TOREM;LUPLAC;Luprac;AC-4464;JDL-464;GJ-1090;BM-02015
- CBNumber:
- CB1397929
- Molecular Formula:
- C16H20N4O3S
- Molecular Weight:
- 348.42
- MOL File:
- 56211-40-6.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/10/27 17:04:05
| Melting point | 163-164°C |
|---|---|
| Density | 1.283±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | DMSO: soluble18mg/mL |
| pka | 6.44(at 25℃) |
| form | solid |
| color | White |
| Water Solubility | Soluble |
| Merck | 14,9552 |
| BCS Class | 1 |
| InChIKey | NGBFQHCMQULJNZ-UHFFFAOYSA-N |
| CAS DataBase Reference | 56211-40-6(CAS DataBase Reference) |
| EPA Substance Registry System | 3-Pyridinesulfonamide, N-[[(1-methylethyl)amino]carbonyl]-4-[(3-methylphenyl)amino]- (56211-40-6) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H319-H361fd | |||||||||
| Precautionary statements | P201-P202-P264-P280-P305+P351+P338-P308+P313 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36-36/37/38 | |||||||||
| Safety Statements | 26-37/39 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | UT7938000 | |||||||||
| HS Code | 2935904000 | |||||||||
| NFPA 704 |
|
Torasemide price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | T3202 | Torsemide ≥98% (HPLC), solid | 56211-40-6 | 10MG | ₹14635.4 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | T3202 | Torsemide ≥98% (HPLC), solid | 56211-40-6 | 50MG | ₹58390.05 | 2022-06-14 | Buy |
| TCI Chemicals (India) | T2538 | Torsemide | 56211-40-6 | 1G | ₹9000 | 2022-05-26 | Buy |
| TCI Chemicals (India) | T2538 | Torsemide | 56211-40-6 | 5G | ₹14800 | 2022-05-26 | Buy |
Torasemide Chemical Properties,Uses,Production
Description
Torasemide is a novel loop diuretic launched in 1993 after a 12-year gap from the last diuretic introduction. It is indicated for the treatment of hypertension and edema associated with chronic congestive heart failure, renal disease and hepatic cirrhosis. Torasemide exerts its major diuretic activity on the thick ascending limb of the Henle's loop to promote rapid and marked excretion of water, Na+, Cl-, and to a lesser extent,K+ and Ca2+. Compared with other loop diuretics such as furosemide, torasemide has a stronger antihypertensive action, a higher bioavailability, a longer duration of action that is independent of the renal function, and has no side effects such as paradoxical antidiuresis. The mechanism of its vasodilating effect has been suggested to result from, at least in part, the competitive antagonism of the thromboxane A2 receptor.
Chemical Properties
Crystalline Solid
Uses
Torasemide is a loop diuretic. Diuretics have been abused as performance-enhancing drugs and masking agents in doping in sports. Use of torsemide is effective for the treatment of edema associated with chronic renal failure. The pharmacology of torasemide is similar to that of frusemide,though torasemide has a longer duration of action with a plasma half-life of approximately 3.5 hours. It also causes a less marked loss of potassiumand calcium.
Definition
ChEBI: Torasemide is an N-sulfonylurea obtained by formal condensation of [(3-methylphenyl)amino]pyridine-3-sulfonic acid with the free amino group of N-isopropylurea. It is a potent loop diuretic used for the treatment of hypertension and edema in patients with congestive heart failure. It has a role as a loop diuretic and an antihypertensive agent. It is a N-sulfonylurea, an aminopyridine and a secondary amino compound. It is functionally related to a 4-aminopyridine.
Torasemide Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Synthetic Research Pharma Laboratories Pvt Ltd | +91 9848023377 | Hyderabad, India | 116 | 58 | Inquiry |
| Siddhivinayakchemicals | +91-912225190111 +91-9819773074 | Mumbai, India | 42 | 58 | Inquiry |
| PANCHSHEEL ORGANICS LTD | +91-9821053955 +91-9324201019 | Mumbai, India | 82 | 58 | Inquiry |
| Prayosha Health Care Pvt Ltd | +91-9924448881 +91-9924448881 | Gujarat, India | 15 | 58 | Inquiry |
| Aurobindo Pharma Limited | +914066725000 | Telangana, India | 112 | 58 | Inquiry |
| Apotex Pharmachem India Pvt Ltd | +91-8022891034 +91-8022891000 | Karnataka, India | 109 | 58 | Inquiry |
| Cipla Ltd | +912224826000 | Maharashtra, India | 133 | 58 | Inquiry |
| Hetero Drugs Limited | +91-4023704923 +91-4023704923 | Telangana, India | 296 | 58 | Inquiry |
| Honour Lab Limited | +919845977466 | Telangana, India | 164 | 58 | Inquiry |
| Ipca Laboratories Ltd | +91-2262105000 +91-2262105000 | Maharashtra, India | 61 | 58 | Inquiry |