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ChemicalBook > Product Catalog >API >Nervous system drugs >Antiepileptic and anticonvulsant >ETHOTOIN

ETHOTOIN

ETHOTOIN Structure
CAS No.
86-35-1
Chemical Name:
ETHOTOIN
Synonyms
Peganone;AC-695;Accenon;Etbotoin;ETHOTOIN;Pegoanone;ETHOTOIN (200 MG);ETHOTOIN USP/EP/BP;Ethotoin (1264501);Ethotoin ((±)-Ethotoin)
CBNumber:
CB0500515
Molecular Formula:
C11H12N2O2
Molecular Weight:
204.23
MOL File:
86-35-1.mol
MSDS File:
SDS
Modify Date:
2023/6/8 9:02:09
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ETHOTOIN Properties

Melting point 94°C
Boiling point 342.72°C (rough estimate)
Density 1.1754 (rough estimate)
refractive index 1.5200 (estimate)
storage temp. Refrigerator
solubility Dichloromethane (Slightly), DMSO (Slightly), Methanol (Slightly)
form Solid
pka 8.01±0.70(Predicted)
color White to Off-White

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312-P330-P501
Risk Statements  22
HS Code  2933210000
NFPA 704
0
1 0

ETHOTOIN Chemical Properties,Uses,Production

Uses

Ethotoin is a hydantoin based anticonvulsant drug used in the treatment of epilepsy.

Definition

ChEBI: An imidazolidine-2,4-dione that is hydantoin substituted by ethyl and phenyl at positions 3 and 5, respectively. An antiepileptic, it is less toxic than phenytoin but also less effective.

Metabolism

Ethotoin differs from phenytoin in that one phenyl substituent at position 5 has been replaced by hydrogen, and the N-H at position 3 is replaced by an ethyl group. It may be indicated for treatment of tonic-clonic and complex partial (psychomotor) seizures. Because it is considered to be less toxic but also less effective and more sedating than phenytoin, ethotoin usually is reserved for use as an add-on drug. Ethotoin does not share phenytoin's profile of antiarrhythmic action. The metabolism of ethotoin, like phenytoin, is saturable and nonlinear. Its administration is contraindicated in patients with hepatic abnormalities and hematologic disorders.

Purification Methods

It is an anticonvulsant and is used in epilepsy. [Dudley et al. J Heterocycl Chem 10 173 1973, Pinner Chem Ber 21 2320 1888, Beilstein 25 III/IV 963, 27 II 860.]

ETHOTOIN Preparation Products And Raw materials

Raw materials

Iodoethane Mandelonitrile Hydrochloric acid

Preparation Products

ETHOTOIN Suppliers

Global( 32)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6773 58 Inquiry
Pharma Affiliates 172-5066494 Haryana, India 6761 58 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32836 60 Inquiry
Shaanxi Didu New Materials Co. Ltd +86-89586680 +86-13289823923 China 8673 58 Inquiry
Aladdin Scientific +1-+1(833)-552-7181 United States 57511 58 Inquiry
Hubei Qingbei Yunyan Pharmaceutical Technology Co., Ltd 18162595016; 18162595016 China 9116 58 Inquiry
Shanghai Aladdin Biochemical Technology Co.,Ltd. +86-18521732826 China 48465 58 Inquiry
Jinan Jiuli Biotechnology Co. , Ltd. 15865264761 China 2956 58 Inquiry
Shanghai Haohong Pharmaceutical Co., Ltd. 400-8210725 4008210725 China 40037 58 Inquiry
Supplier Advantage
CLEARSYNTH LABS LTD. 58
Pharmaffiliates Analytics and Synthetics P. Ltd 58
Pharma Affiliates 58
ATK CHEMICAL COMPANY LIMITED 60
Shaanxi Didu New Materials Co. Ltd 58
Aladdin Scientific 58
Hubei Qingbei Yunyan Pharmaceutical Technology Co., Ltd 58
Shanghai Aladdin Biochemical Technology Co.,Ltd. 58
Jinan Jiuli Biotechnology Co. , Ltd. 58
Shanghai Haohong Pharmaceutical Co., Ltd. 58

ETHOTOIN Spectrum

ETHOTOIN(86-35-1)MSETHOTOIN(86-35-1)IR1ETHOTOIN(86-35-1)IR2

86-35-1(ETHOTOIN )Related Search:

ETHOTOIN 5-Phenylhydantoin Hydantoin Ropitoin (+/-)-N-3-Benzylnirvanol
[4-(4-METHOXY-PHENYL)-4-METHYL-2,5-DIOXO-IMIDAZOLIDIN-1-YL]-ACETIC ACID 5,5-DIPHENYLHYDANTOIN-3-BUTYRIC ACID (2,5-DIOXO-3',4'-DIHYDRO-1H,2'H-SPIRO[IMIDAZOLIDINE-4,1'-NAPHTHALEN]-1-YL)ACETIC ACID 1-(4-(2-Hydroxyethyl)-1-piperazine-2-propanolo)-3-ethyl-5,5-diphenylhy dantoin 2HCl hydrate [4-(4-FLUOROPHENYL)-4-METHYL-2,5-DIOXOIMIDAZOLIDIN-1-YL]ACETIC ACID
(4-[4-(2-AMINO-2-OXOETHOXY)PHENYL]-4-METHYL-2,5-DIOXOIMIDAZOLIDIN-1-YL)ACETIC ACID 2,4-Imidazolidinedione, 5,5-diphenyl-3-ethyl-1-(2-hydroxy-3-(1-piperid inyl)propyl)-, monohydrochloride [4-METHYL-4-(2-NAPHTHYL)-2,5-DIOXOIMIDAZOLIDIN-1-YL]ACETIC ACID [4-METHYL-4-(4-METHYLPHENYL)-2,5-DIOXOIMIDAZOLIDIN-1-YL]ACETIC ACID (4-ETHYL-2,5-DIOXO-4-PHENYLIMIDAZOLIDIN-1-YL)ACETIC ACID
(4-METHYL-2,5-DIOXO-4-PHENYL-IMIDAZOLIDIN-1-YL)-ACETIC ACID (2',5'-DIOXO-2,3-DIHYDRO-1'H-SPIRO[CHROMENE-4,4'-IMIDAZOLIDIN]-1'-YL)ACETIC ACID (2,5-DIOXO-2',3'-DIHYDRO-1H-SPIRO[IMIDAZOLIDINE-4,1'-INDEN]-1-YL)ACETIC ACID
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1-Ethyl-2,5-dioxo-4-phenylimidazolidine 2,4-Imidazolidinedione, 3-ethyl-5-phenyl- 3-Ethyl-5-phenyl-2,4-imidazolidinedione 3-ethyl-5-phenyl-hydantoi 3-Ethyl-5-Phenylhydantoin 3-Ethyl-5-phenylimidazolidin-2,4-dione AC-695 Accenon Hydantoin, 3-ethyl-5-phenyl- Pegoanone ETHOTOIN (200 MG) Etbotoin Hydantoin, 3-ethyl-5-phenyl- (6CI, 7CI, 8CI) 3-ethyl-5-phenyl-imidazolidine-2,4-dione 3-ethyl-5-phenylimidazolidine-2,4-dione ETHOTOIN ETHOTOIN USP/EP/BP Ethotoin ((±)-Ethotoin) Ethotoin (1264501) Peganone 86-35-1