9-Oxo-10(9H)-acridineacetic acid
- CAS No.
- 38609-97-1
- Chemical Name:
- 9-Oxo-10(9H)-acridineacetic acid
- Synonyms
- ACRIDONE ACETIC ACID;Cridanimod;10-carboxymethyl-9-acridanone;10-Cma;XBIO-101;AI3-05733;HSDB 2647;Aids000901;Aids-000901;Brn 0227508
- CBNumber:
- CB0502504
- Molecular Formula:
- C15H11NO3
- Molecular Weight:
- 253.25
- MOL File:
- 38609-97-1.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/4/22 9:03:41
| Melting point | ~289 °C (dec.) |
|---|---|
| Boiling point | 486.6±34.0 °C(Predicted) |
| Density | 1.362 |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Aqueous Base (Slightly), DMSO (Slightly) |
| form | Solid |
| pka | 3.69±0.10(Predicted) |
| color | Pale Yellow to Light Yellow |
| λmax | 410nm(H2O)(lit.) |
| BRN | 227508 |
| InChI | InChI=1S/C15H11NO3/c17-14(18)9-16-12-7-3-1-5-10(12)15(19)11-6-2-4-8-13(11)16/h1-8H,9H2,(H,17,18) |
| InChIKey | UOMKBIIXHQIERR-UHFFFAOYSA-N |
| SMILES | C1=C2C(N(CC(O)=O)C3=C(C2=O)C=CC=C3)=CC=C1 |
| CAS DataBase Reference | 38609-97-1(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | AR7190000 | |||||||||
| HS Code | 2933.99.8290 | |||||||||
| NFPA 704 |
|
9-Oxo-10(9H)-acridineacetic acid price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 17927 | 9-Oxo-10(9H)-acridineacetic acid for HPLC derivatization, ≥99.0% (T) | 38609-97-1 | 250MG | ₹18153.53 | 2022-06-14 | Buy |
| TCI Chemicals (India) | O0432 | 9-Oxoacridine-10-acetic Acid | 38609-97-1 | 1G | ₹4300 | 2022-05-26 | Buy |
| TCI Chemicals (India) | O0432 | 9-Oxoacridine-10-acetic Acid | 38609-97-1 | 5G | ₹9500 | 2022-05-26 | Buy |
9-Oxo-10(9H)-acridineacetic acid Chemical Properties,Uses,Production
Definition
Acriridone derivatives have become a research hotspot in the field of medicine in recent years due to their good antibacterial, anti-inflammatory, anti-malarial, and anti-cancer activities. This type of compound has a rigid planar structure of a macrocyclic conjugated system and can be embedded or Electrostatic attraction binds to DNA. Among them, 9-aminoacridine derivatives have good pharmacological and biological activities, and some of them have been used clinically as DNA embedding reagents. As an important pharmaceutical intermediate, 9-Oxo-10(9H)-acridineacetic acid has also received increasing attention. Cridanimod (9-Oxo-10(9H)-acridineacetic acid) is a potent progesterone receptor (PR) activator mediated through induction of IFNα and IFNβ expression. Cridanimod is a small-molecule immunomodulator and interferon inducer.
Description
9-Oxo-10(9H)-acridineacetic acid , also known as Cridanimod or XBIO-101, is a small molecule that can increase progesterone receptor (PR) expression, with potential antineoplastic adjuvant activity. Cridanimod is able to induce the expression of PR in endometrial cancer. This could increase the sensitivity of endometrial cancer cells to progestin monotherapy. In combination with a progestin, cancer cells could be eradicated through increased PR-mediated signaling, leading to an inhibition of luteinizing hormone (LH) release from the pituitary gland, via a negative feedback mechanism, and, eventually, an inhibition of estrogen release from the ovaries. This leads to an inhibition of cellular growth in estrogen-dependent tumor cells.
Uses
9-Oxo-10(9H)-acridineacetic acid is a reagent for pre-column derivatization of amino acids for fluorescent determination in HPLC and it is also a building block in pharmaceutics.
9-Oxo-10(9H)-acridineacetic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Euro-India Chems Pvt., Ltd. | 91-22-66923581 | Maharashtra, India | 31 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| Zhengzhou Lingzhiyue Technology Co., Ltd | +86-0371-55074660 +86-13783527580 | China | 3152 | 58 | Inquiry |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | China | 20366 | 58 | Inquiry |
| Shaanxi TNJONE Pharmaceutical Co., Ltd | +8618740459177 | China | 1142 | 58 | Inquiry |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | China | 16221 | 58 | Inquiry |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | China | 21677 | 55 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29901 | 58 | Inquiry |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | China | 39916 | 58 | Inquiry |
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