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Amsacrine hydrochloride

Amsacrine hydrochloride Structure
CAS No.
54301-15-4
Chemical Name:
Amsacrine hydrochloride
Synonyms
nsc141549;nci-c03190;M-AMSA, HCL;M-Amsacrine;Amsacrine HCI;META-AMSACRINE;AMSA hydrochloride;M-AMSA HYDROCHLORIDE;AMSACRINE HYDROCHLORIDE;acridinyl anisidide hydrochloride
CBNumber:
CB4236395
Molecular Formula:
C21H20ClN3O3S
Molecular Weight:
429.92
MOL File:
54301-15-4.mol
MSDS File:
SDS
Modify Date:
2023/6/8 17:06:34
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Amsacrine hydrochloride Properties

Melting point 197-199 °C(lit.)
storage temp. Refrigerator
solubility DMSO: 10 mg/mL with heat and sonication
form powder
color red to brown

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS06,GHS08
Signal word  Danger
Hazard statements  H301-H317-H341-H351-H361d
Precautionary statements  P202-P261-P264-P280-P301+P310-P302+P352
Hazard Codes  T
Risk Statements  25-36/37/38
Safety Statements  26-45
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS  PB1081000
HS Code  2933.99.8290
HazardClass  6.1(b)
PackingGroup  III
NFPA 704
0
2 0

Amsacrine hydrochloride price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) A9809 Amsacrine hydrochloride ≥98% (TLC), powder 54301-15-4 10MG ₹26640.33 2022-06-14 Buy
Sigma-Aldrich(India) A9809 Amsacrine hydrochloride ≥98% (TLC), powder 54301-15-4 50MG ₹104190.63 2022-06-14 Buy
TCI Chemicals (India) A2777 Amsacrine Hydrochloride 54301-15-4 20MG ₹7500 2022-05-26 Buy
TCI Chemicals (India) A2777 Amsacrine Hydrochloride 54301-15-4 100MG ₹15000 2022-05-26 Buy
Product number Packaging Price Buy
A9809 10MG ₹26640.33 Buy
A9809 50MG ₹104190.63 Buy
A2777 20MG ₹7500 Buy
A2777 100MG ₹15000 Buy

Amsacrine hydrochloride Chemical Properties,Uses,Production

Uses

Amsacrine hydrochloride has been used:

  • as a topoisomerase poison in bacteriophage T4 topoisomerase assay
  • as a topoisomerase inhibitor in Drosophila cell line, Kc167
  • as an antileukemia drug to test its effect on p53 transcriptional activity in tumor xenografts
  • as a topoisomerase II poison in dose-response assays in C elegans

Biochem/physiol Actions

Amsacrine (m-AMSA) is a derivative of acridine and an antileukemia drug. It is an anticancer drug with antineoplastic activity that targets topoisomerase II. AMSA is an apoptosis inducer and favors the accumulation of double-stranded breaks (DSBs). It also inhibits the expression of matrix metallopeptidase 2 (MMP-2) and MMP-9 expression in leukemia cells by generating reactive oxygen species (ROS). AMSA serves as an adjuvant in trabeculectomy surgery.

Amsacrine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

Amsacrine

Amsacrine hydrochloride Suppliers

Global( 105)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Sadasivarao g +91 9515157878 Hyderabad, India 107 58 Inquiry
TCI Chemicals (India) Pvt. Ltd. 1800 425 7889 New Delhi, India 6778 58 Inquiry
SL Drugs and Pharmaceuticals Pvt. Ltd. +91 (40) 6661-1133 New Delhi, India 2688 50 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32760 60 Inquiry
CONIER CHEM AND PHARMA LIMITED +8618523575427 China 49391 58 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29826 58 Inquiry
Zhengzhou Alfa Chemical Co.,Ltd +8618530059196 China 13102 58 Inquiry
SIMAGCHEM CORP +86-13806087780 China 17367 58 Inquiry
LEAP CHEM CO., LTD. +86-852-30606658 China 24738 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 United States 19973 58 Inquiry
Supplier Advantage
Sadasivarao g 58
TCI Chemicals (India) Pvt. Ltd. 58
SL Drugs and Pharmaceuticals Pvt. Ltd. 50
ATK CHEMICAL COMPANY LIMITED 60
CONIER CHEM AND PHARMA LIMITED 58
career henan chemical co 58
Zhengzhou Alfa Chemical Co.,Ltd 58
SIMAGCHEM CORP 58
LEAP CHEM CO., LTD. 58
TargetMol Chemicals Inc. 58

Amsacrine hydrochloride Spectrum

Amsacrine hydrochloride(54301-15-4)1HNMR

54301-15-4(Amsacrine hydrochloride)Related Search:

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Quinacridone 2-ETHOXY-6,9-DIAMINOACRIDINE Dopamine hydrochloride Amiodarone hydrochloride 6,9-DIAMINO-2-ETHOXYACRIDINE LACTATE
9(10H)-ACRIDONE anisidine M-ANISIDINE HYDROCHLORIDE Amsacrine/Amsacrine hydrochloride,Amsacrine/Amsacrine hydrochloride DL-Norephedrine hydrochloride
Methanesulfonamide Amsacrine hydrochloride Amsacrine, HCl
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m-AMSA, 4-(9-Acridinylamino)-N-(methanesulfonyl)-m-anisidine hydrochloride Methanesulfone-m-anisidine-4'-[(9-acridinyl)amino] hydrochloride Methanesulfon-m-anisidide 4'-(9-acridinylamino)- Methansulfon-m-aniside, 4'-(9-acridinylamino)-, monohydrochloride 4-[9-ACRIDINYLAMINO]-N-[METHANE-SULFONYL]-M-ANISIDINE HYDROCHLORIDE M-AMSA HYDROCHLORIDE M-AMSA, HCL Methanesulfonamide, N-4-(9-acridinylamino)-3-methoxyphenyl-, monohydrochloride M-Amsacrine META-AMSACRINE N-(4-(acridin-9-ylaMino)-3-Methoxyphenyl)MethanesulfonaMide hydrochloride MethanesulfonaMide,N-[4-(9-acridinylaMino)-3-Methoxyphenyl]-, hydrochloride (1:1) AMine hydrochloride benzene acridine AMSACRINE HYDROCHLORIDE nsc141549 4’-((9-acridinyl)amino)-methanesulfon-m-anisidinhydrochloride 4’-(9-acridinylamino)methanesulfon-m-anisidemonohydrochloride 4’-(9-acridinylamino)-methanesulfon-m-anisididmonohydrochloride 4’-(9-acridinylamino)-methanesulfonyl-m-anisidinmonohydrochloride n-(4-(9-acridinylamino)-3-methoxyphenyl)-methanesulfonamidmonohydrochlor nci-c03190 AMSA hydrochloride Amsacrine Hydrochloride, 4-(9-Acridinylamino)-N-(Methanesulfonyl)-M-Anisidine Hydrochloride Amsacrine hydrochloride, ≥98% (HPLC) acridinyl anisidide hydrochloride Amsacrine HCI 54301-15-4 C21H19N3O3S C21H19N3O3SHCl Apoptosis and Cell Cycle BioChemical Cell Biology Cell Signaling and Neuroscience DNA metabolism DNA Repair Regulators