cis-4-Hydroxycyclohexanecarboxylic acid
- CAS No.
- 3685-22-1
- Chemical Name:
- cis-4-Hydroxycyclohexanecarboxylic acid
- Synonyms
- CIS-4-HYDROXYCYCLOHEXANECARBOXYLIC ACID;CIS-4-HYDROXYCYCLOHEXANECARBOXYLIC ACID;RANS-4-HYDROXYCYCLOHEXANECARBOXYLIC ACID;TRANS-4-HYDROXYCYCLOHEXANECARBOXYLIC ACID;cis-4-HydroxycyclohexanecarboxylicAcid>cis-4-Hydroxycyclohexane-1-carboxylic acid;(1s,4s)-4-hydroxycyclohexanecarboxylic acid;Cyclohexanecarboxylic acid, 4-hydroxy-, cis-;(1s,4s)-4-hydroxycyclohexane-1-carboxylic acid;cis-4-Hydroxycyclohexanecarboxylic Acid
- CBNumber:
- CB0727376
- Molecular Formula:
- C7H12O3
- Molecular Weight:
- 144.17
- MOL File:
- 3685-22-1.mol
- Modify Date:
- 2024/7/19 18:29:52
| Melting point | 150°C |
|---|---|
| Boiling point | 115 °C(Press: 8 Torr) |
| Density | 1.246 |
| storage temp. | 2-8°C |
| solubility | almost transparency in Methanol |
| form | powder to crystal |
| pka | pK1:4.836 (25°C) |
| color | White to Almost white |
| InChI | InChI=1S/C7H12O3/c8-6-3-1-5(2-4-6)7(9)10/h5-6,8H,1-4H2,(H,9,10)/t5-,6+ |
| InChIKey | HCFRWBBJISAZNK-OLQVQODUSA-N |
| SMILES | [C@@H]1(C(O)=O)CC[C@H](O)CC1 |
| CAS DataBase Reference | 3685-22-1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319 | |||||||||
| Precautionary statements | P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313 | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 36/37/38-25 | |||||||||
| Safety Statements | 26-36/37/39-45 | |||||||||
| RIDADR | UN 2811 6.1 / PGIII | |||||||||
| HS Code | 2918199890 | |||||||||
| NFPA 704 |
|
cis-4-Hydroxycyclohexanecarboxylic acid price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | ANV00233 | cis-4-Hydroxycyclohexanecarboxylic acid AldrichCPR | 3685-22-1 | 1G | ₹15003.45 | 2022-06-14 | Buy |
| TCI Chemicals (India) | H0980 | cis-4-Hydroxycyclohexanecarboxylic Acid min. 98.0 % | 3685-22-1 | 5G | ₹12100 | 2022-05-26 | Buy |
| TCI Chemicals (India) | H0980 | cis-4-Hydroxycyclohexanecarboxylic Acid min. 98.0 % | 3685-22-1 | 25G | ₹26000 | 2022-05-26 | Buy |
cis-4-Hydroxycyclohexanecarboxylic acid Chemical Properties,Uses,Production
Chemical Properties
White to Almost white powder to crystal. Melting point: 148.0 to 152.0 °C.
Uses
Cis-4-Hydroxycyclohexanecarboxylic acid is a metabolite of p-hydroxybenzoic acid. It is the major metabolite in the urine of rats treated with exogenous p-hydroxybenzoic acid. It has been found to have immunosuppressive activities in rat hepatocytes, as well as metabolic disorders that are related to hyperglycemia or diabetes mellitus.
Synthesis
cis-4-Hydroxycyclohexanecarboxylic acid can be synthesized through the following steps:
1. In an argon glove box, dissolve ligands L1-(S,R)-f-ambinol (7.5mg, 0.0105mmol) and [Ir(COD)Cl]2 (3.4mg, 0.005mmol) in 1 mL of iPrOH in a 2mL vial and stir at room temperature for 2 h.
2. Put 1 mmol of raw material 4-substituted cyclohexanone into a 4 mL hydrogenation flask.
3. Add 0.1 mL of the in-situ complexed catalyst solution and 1.6 mg of tBuOLi solid powder to the hydrogenation flask.
4. Add 1 mL of EtOH to dissolve the reactants in the hydrogenation flask.
5. Put the reaction flask into the hydrogenation kettle and replace the kettle body with hydrogen three times.
6. Fill the kettle with 5bar H2 and react at room temperature for 12h.
7. After the reaction is completed, carefully release the hydrogen and spin-dry the solvent under reduced pressure.
8. Purify the hydrogenated product cis-4-substituted cyclohexanol by silica gel column.
9. Obtain the final product cis-4-Hydroxycyclohexanecarboxylic acid.
cis-4-Hydroxycyclohexanecarboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| CHEMSWORTH | +91-261-2397244 | New Delhi, India | 6707 | 30 | Inquiry |
| Biokemix | +91 (40) 6662-6366 | New Delhi, India | 487 | 50 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-81138252 +86-18789408387 | China | 3958 | 58 | Inquiry |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | China | 29798 | 60 | Inquiry |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | China | 18623 | 58 | Inquiry |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32835 | 60 | Inquiry |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | China | 8348 | 58 | Inquiry |
| Accela ChemBio Inc. | +1-858-6993322 | United States | 19673 | 58 | Inquiry |
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