ChemicalBook > Product Catalog >API >Drugs Influencing Immune Function >Immunosuppressive drugs >Diacerein
Diacerein
- CAS No.
- 13739-02-1
- Chemical Name:
- Diacerein
- Synonyms
- DAR;Diacereine;SF 277;artrodar;Fisiodar;ICN17261;DIACEREIN;ICN 17261;ICN-17261;DIACERHEIN
- CBNumber:
- CB0755179
- Molecular Formula:
- C19H12O8
- Molecular Weight:
- 368.29
- MOL File:
- 13739-02-1.mol
- Modify Date:
- 2024/8/21 22:41:43
| Melting point | 217-2180C |
|---|---|
| Boiling point | 631.5±55.0 °C(Predicted) |
| Density | 1.491±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO (Sparingly), Methanol (Slightly) |
| pka | 3.01±0.20(Predicted) |
| form | Solid |
| color | Light Yellow to Yellow |
| Water Solubility | 240μg/L at 25℃ |
| Merck | 14,2960 |
| InChIKey | TYNLGDBUJLVSMA-UHFFFAOYSA-N |
| LogP | 3.126 (est) |
| CAS DataBase Reference | 13739-02-1(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | CB8781000 | |||||||||
| HS Code | 29146990 | |||||||||
| Toxicity | rat,LD50,unreported,7500mg/kg (7500mg/kg),Drugs of the Future. Vol. 4, Pg. 445, 1979. | |||||||||
| NFPA 704 |
|
Diacerein price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | D9302 | Diacerein ≥95% (HPLC) | 13739-02-1 | 50MG | ₹17471.55 | 2022-06-14 | Buy |
| TCI Chemicals (India) | D4061 | Diacerein | 13739-02-1 | 1G | ₹8900 | 2022-05-26 | Buy |
| TCI Chemicals (India) | D4061 | Diacerein | 13739-02-1 | 5G | ₹19800 | 2022-05-26 | Buy |
| ottokemi | D 1332 | Diacerein, 95% | 13739-02-1 | 10mg | ₹7605 | 2022-05-26 | Buy |
| ottokemi | D 1332 | Diacerein, 95% | 13739-02-1 | 50mg | ₹18189 | 2022-05-26 | Buy |
Diacerein Chemical Properties,Uses,Production
Description
Diacerein is a disease-modifying antirheumatic drug (DMARD), reported to be useful in the treatment of various inflammatory conditions, including osteoarthritis. It forms water soluble chelates with calcium and copper, acting ultimately to reduce the activity of lysosomal enzymes and decrease the formation of rheumatoid factor.
Chemical Properties
Yellow Crystalline Solid
Uses
Diacerein is a diacetyl precursor of rhein, an anthraquinone found in plants. Rhein, at 10 μM, inhibits IL-1β signaling, suppressing signaling through NF-κB and AP-1, and reduces the expression of the matrix metalloproteases MMP-1 and MMP-13. Diacerein, presumably after conversion to rhein, down-regulates the expression of the IL-1β receptor on articular chondrocytes, enhances the expression of TGF-β, and increases collagen and aggrecan. It does not alter COX activity. It is mildly effective in ameliorating osteoarthritis.
Diacerein Preparation Products And Raw materials
Global( 539)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Siddhivinayakchemicals | +91-912225190111 +91-9819773074 | Mumbai, India | 42 | 58 | Inquiry |
| Micro Orgo Chem | +91-91-022-24969510 +91-9082984052 | Mumbai, India | 66 | 58 | Inquiry |
| Global Pharma | +91-9819994077 +91-9819994077 | Maharashtra, India | 34 | 58 | Inquiry |
| Gonane Pharma | +91-9819380043 +91-9819380043 | NaviMumbai, India | 192 | 58 | Inquiry |
| Medi Pharma Drug House | +919930911911 | Mumbai, India | 143 | 58 | Inquiry |
| Rivashaa Agrotech Biopharma Pvt. Ltd. | +91-26463395 +91-7926462688 | Gujarat, India | 1615 | 58 | Inquiry |
| ALS INDIA LIFE SCIENCES | +91-8977036379 +91-8977036379 | Hyderabad, India | 1879 | 58 | Inquiry |
| Believe Pharma | +91-9376562200 +91-7990821661 | Gujarat, India | 19 | 58 | Inquiry |
| Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
| Ami Lifesciences Pvt Ltd | +91-9426998100 +91-9426998100 | Gujarat, India | 62 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Siddhivinayakchemicals | 58 |
| Micro Orgo Chem | 58 |
| Global Pharma | 58 |
| Gonane Pharma | 58 |
| Medi Pharma Drug House | 58 |
| Rivashaa Agrotech Biopharma Pvt. Ltd. | 58 |
| ALS INDIA LIFE SCIENCES | 58 |
| Believe Pharma | 58 |
| Ralington Pharma | 58 |
| Ami Lifesciences Pvt Ltd | 58 |
13739-02-1(Diacerein)Related Search:
1,8-DIACETOXY-3-CARBOXYANTHRAQUINONE
DIACEREIN
DIACERHEIN
DIACETYL RHEIN
9,10-dihydro-4,5-diacetoxy-9,10-2-anthracenecarboxylicacid
9,10-dihydro-4,5-dihydroxy-9,10-dioxo-2-anthroicaciddiacetate
9,10-dihydro-4,5-dihydroxy-9,10-dioxo-2-anthroicacidiacetate
artrodar
rhein,diacetate
4,5-Bis(acetyloxy)-9,10-dioxo-2-anthracenecarboxylic acid
4,5-Bis(acetyloxy)-9,10-dihydro-9,10-dioxo-2-anthracenecarboxylic Acid
1,8-diacetoxyanthraquinone-3-carboxylicacid
4,5-bis(acetyloxy)-9,10-dihydro-9,10-dioxo-2-anthracenecarboxylicaci
4,5-diacetylrhein
4,5-Diacetoxy-9,10-dihydro-9,10-dioxo-2-anthracenecarboxylic acid
4,5-Diacetoxy-9,10-dioxo-2-anthracenecarboxylic acid
4,5-diacetoxy-9,10-diketo-anthracene-2-carboxylic acid
4,5-diacetyloxy-9,10-dioxo-anthracene-2-carboxylic acid
4,5-diacetyloxy-9,10-dioxoanthracene-2-carboxylic acid
Diacerein (1,8-Diacetoxy-3-carboxyanthraquinone)
4,5-Diacetoxyanthraquinone-2-carboxylic Acid
Fisiodar
SF 277
4,5-diacetoxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylic acid
DIACETYL RHEIN(P)
Diacerein, ≥95%（HPLC)
4,5-diacetyloxy-9,10-dioxo-2-anthracenecarboxylic acid
Diacerein 13739-02-1
DIACERHEIN;DIACETYLRHEIN;FISIODAR;ARTRODAR
Diacerein CRS
Diacerein>
Diacerein impurity mixture CRS
2-Anthracenecarboxylic acid, 4,5-bis(acetyloxy)-9,10-dihydro-9,10-dioxo-
Diacerein for Arthritis Treatment
Diacerein USP/EP/BP
Diacerein (Diacerhein)
Diacerein(Y0001595)
DiacereinQ: What is
Diacerein Q: What is the CAS Number of
Diacerein Q: What is the storage condition of
Diacerein Q: What are the applications of
Diacerein
Diacerein API
ICN 17261
ICN17261
ICN-17261
Diacereine
DAR
Diacerein, ≥ 98.0%
Diacerhein|||Fisiodar|||Diacetylrhein
Diacerein IP/EP
13739-02-1
C19H12O8
Analytical Standards
Analytical Chromatography Product Catalog
Drug Standards
Chromatography
Forensic and Veterinary Standards
Miscellaneous Biochemicals
Aromatics Compounds
Aromatics
Heterocycles