Diacerein
![Diacerein Structure](CAS/GIF/13739-02-1.gif)
- CAS No.
- 13739-02-1
- Chemical Name:
- Diacerein
- Synonyms
- DAR;Diacereine;SF 277;artrodar;Fisiodar;ICN17261;DIACEREIN;ICN 17261;ICN-17261;DIACERHEIN
- CBNumber:
- CB0755179
- Molecular Formula:
- C19H12O8
- Molecular Weight:
- 368.29
- MOL File:
- 13739-02-1.mol
- Modify Date:
- 2024/8/21 22:41:43
Melting point | 217-2180C |
---|---|
Boiling point | 631.5±55.0 °C(Predicted) |
Density | 1.491±0.06 g/cm3(Predicted) |
storage temp. | Sealed in dry,Room Temperature |
solubility | DMSO (Sparingly), Methanol (Slightly) |
pka | 3.01±0.20(Predicted) |
form | Solid |
color | Light Yellow to Yellow |
Water Solubility | 240μg/L at 25℃ |
Merck | 14,2960 |
InChIKey | TYNLGDBUJLVSMA-UHFFFAOYSA-N |
LogP | 3.126 (est) |
CAS DataBase Reference | 13739-02-1(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H315-H319-H335 | |||||||||
Precautionary statements | P305+P351+P338 | |||||||||
Hazard Codes | Xi | |||||||||
Risk Statements | 36/37/38 | |||||||||
Safety Statements | 26-36 | |||||||||
WGK Germany | 3 | |||||||||
RTECS | CB8781000 | |||||||||
HS Code | 29146990 | |||||||||
Toxicity | rat,LD50,unreported,7500mg/kg (7500mg/kg),Drugs of the Future. Vol. 4, Pg. 445, 1979. | |||||||||
NFPA 704 |
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Diacerein price More Price(6)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich(India) | D9302 | Diacerein ≥95% (HPLC) | 13739-02-1 | 50MG | ₹17471.55 | 2022-06-14 | Buy |
TCI Chemicals (India) | D4061 | Diacerein | 13739-02-1 | 1G | ₹8900 | 2022-05-26 | Buy |
TCI Chemicals (India) | D4061 | Diacerein | 13739-02-1 | 5G | ₹19800 | 2022-05-26 | Buy |
ottokemi | D 1332 | Diacerein, 95% | 13739-02-1 | 10mg | ₹7605 | 2022-05-26 | Buy |
ottokemi | D 1332 | Diacerein, 95% | 13739-02-1 | 50mg | ₹18189 | 2022-05-26 | Buy |
Diacerein Chemical Properties,Uses,Production
Description
Diacerein is a disease-modifying antirheumatic drug (DMARD), reported to be useful in the treatment of various inflammatory conditions, including osteoarthritis. It forms water soluble chelates with calcium and copper, acting ultimately to reduce the activity of lysosomal enzymes and decrease the formation of rheumatoid factor.
Chemical Properties
Yellow Crystalline Solid
Uses
Diacerein is a diacetyl precursor of rhein, an anthraquinone found in plants. Rhein, at 10 μM, inhibits IL-1β signaling, suppressing signaling through NF-κB and AP-1, and reduces the expression of the matrix metalloproteases MMP-1 and MMP-13. Diacerein, presumably after conversion to rhein, down-regulates the expression of the IL-1β receptor on articular chondrocytes, enhances the expression of TGF-β, and increases collagen and aggrecan. It does not alter COX activity. It is mildly effective in ameliorating osteoarthritis.
Diacerein Preparation Products And Raw materials
Supplier | Tel | Country | ProdList | Advantage | Inquiry |
---|---|---|---|---|---|
Siddhivinayakchemicals | +91-912225190111 +91-9819773074 | Mumbai, India | 42 | 58 | Inquiry |
Micro Orgo Chem | +91-91-022-24969510 +91-9082984052 | Mumbai, India | 66 | 58 | Inquiry |
Global Pharma | +91-9819994077 +91-9819994077 | Maharashtra, India | 34 | 58 | Inquiry |
Gonane Pharma | +91-9819380043 +91-9819380043 | NaviMumbai, India | 192 | 58 | Inquiry |
Medi Pharma Drug House | +919930911911 | Mumbai, India | 143 | 58 | Inquiry |
Rivashaa Agrotech Biopharma Pvt. Ltd. | +91-26463395 +91-7926462688 | Gujarat, India | 1615 | 58 | Inquiry |
ALS INDIA LIFE SCIENCES | +91-8977036379 +91-8977036379 | Hyderabad, India | 1879 | 58 | Inquiry |
Believe Pharma | +91-9376562200 +91-7990821661 | Gujarat, India | 19 | 58 | Inquiry |
Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
Ami Lifesciences Pvt Ltd | +91-9426998100 +91-9426998100 | Gujarat, India | 62 | 58 | Inquiry |
Supplier | Advantage |
---|---|
Siddhivinayakchemicals | 58 |
Micro Orgo Chem | 58 |
Global Pharma | 58 |
Gonane Pharma | 58 |
Medi Pharma Drug House | 58 |
Rivashaa Agrotech Biopharma Pvt. Ltd. | 58 |
ALS INDIA LIFE SCIENCES | 58 |
Believe Pharma | 58 |
Ralington Pharma | 58 |
Ami Lifesciences Pvt Ltd | 58 |