Chrysophanic acid
- CAS No.
- 481-74-3
- Chemical Name:
- Chrysophanic acid
- Synonyms
- CHRYSOPHANOL;RHUBARB EXTRACT;M13;Chrysophal;SEMEN CASSIAE EXTRACT;3-METHYLCHRYSAZIN;M 13;M-13;c.i.75400;NSC 37132
- CBNumber:
- CB9760903
- Molecular Formula:
- C15H10O4
- Molecular Weight:
- 254.24
- MOL File:
- 481-74-3.mol
- Modify Date:
- 2024/5/24 18:18:52
| Melting point | 194-198 °C |
|---|---|
| Boiling point | 357.45°C (rough estimate) |
| Density | 1.2693 (rough estimate) |
| refractive index | 1.4872 (estimate) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | chloroform: soluble1% |
| pka | 6.63±0.20(Predicted) |
| form | crystalline |
| color | yellow-orange |
| Water Solubility | <0.1 g/100 mL at 18 ºC |
| λmax | 429nm(MeOH)(lit.) |
| Merck | 14,2258 |
| BRN | 1252300 |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| LogP | 4.720 (est) |
| CAS DataBase Reference | 481-74-3(CAS DataBase Reference) |
| EPA Substance Registry System | Chrysophanic acid (481-74-3) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/38-36/37/38 | |||||||||
| Safety Statements | 26-36-37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | CB6725000 | |||||||||
| F | 8-10 | |||||||||
| HS Code | 29146990 | |||||||||
| NFPA 704 |
|
Chrysophanic acid price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 229075 | 1,8-Dihydroxy-3-methylanthraquinone 98% | 481-74-3 | 50MG | ₹6495 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 229075 | 1,8-Dihydroxy-3-methylanthraquinone 98% | 481-74-3 | 50MG | ₹6495 | 2022-06-14 | Buy |
| Sigma-Aldrich | 229075 | 1,8-Dihydroxy-3-methylanthraquinone 98% | 481-74-3 | 1G | ₹41102.53 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 229075 | 1,8-Dihydroxy-3-methylanthraquinone 98% | 481-74-3 | 1G | ₹41102.53 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 01542 | Chrysophanol analytical standard | 481-74-3 | 25MG | ₹8216.18 | 2022-06-14 | Buy |
Chrysophanic acid Chemical Properties,Uses,Production
Description
Chrysophanol is an anthraquinone that has been found in R. palmatum and has diverse biological activities. It induces necrosis in J5 human liver cancer cells when used at concentrations of 25, 50, 75, 100, and 200 μM. Chrysophanol (5, 10, and 50 μM) reduces LPS-induced production of nitric oxide (NO) and prostaglandin E2 (PGE2; ) and inhibits LPS-induced DNA oxidation in BV-2 microglia. In vivo, chrysophanol (5 mg/kg) decreases colonic levels of IL-6 and activation of NF-κB and reduces weight loss, diarrhea, and rectal bleeding in a mouse model of colitis induced by dextran sulfate (DSS; ). Chrysophanol (0.1, 1, and 10 mg/kg) increases survival, reduces brain tissue loss, and ameliorates motor balance deficits in a mouse model of ischemia-reperfusion injury induced by middle cerebral artery occlusion (MCAO).
Chemical Properties
yellow crystalline solid or brown powder
Uses
Chrysophanic acid, a natural anthraquinone, is used to study anticancer activity in EGFR-overexpressing SNU-C5 human colon cancer cells 1. It is also used to study the inhibition of replication of poliovirus types 2 and 3 (Picornaviridae) in vitro 2.
Definition
ChEBI: A trihydroxyanthraquinone that is chrysazin with a methyl substituent at C-3. It has been isolated from Aloe vera and exhibits antiviral and anti-inflammatory activity.
General Description
Golden yellow plates or brown powder. Melting point 196°C. Slightly soluble in water. Pale yellow aqueous solutions turn red on addition of alkali. Solutions in concentrated sulfuric acid are red.
Air & Water Reactions
Insoluble in water.
Reactivity Profile
Chrysophanic acid is incompatible with strong oxidizing agents.
Fire Hazard
Flash point data for Chrysophanic acid are not available; however, Chrysophanic acid is probably combustible.
Purification Methods
Crystallise chrysophanic acid from EtOH or *benzene and has m 195.6-196.2o, after sublimation it in a vacuum. The yellow mono-acetate has m 188-190o (from MeOH or Me2CO). It forms Ni2+, Co2+ and Cu2+ complexes. [Beilstein 8 H 470, 8 I 725, 8 II 510, 8 III 3808, 8 IV 3277.]
Chrysophanic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Pioneer Enterprise | 91-22-23472534 | Maharashtra, India | 28 | 58 | Inquiry |
| Phytocompounds | 91-80-40209999 | Karnataka, India | 35 | 58 | Inquiry |
| Shaanxi Cuikang Pharmaceutical Technology Co., Ltd | +8618829768577 | China | 1250 | 58 | Inquiry |
| Shaanxi Cuikang Pharmaceutical Technology Co., Ltd | +86-19164747840 +86-13119157289 | China | 2969 | 58 | Inquiry |
| Hebei Kingfiner Technology Development Co.Ltd | +86-15532196582 +86-15373005021 | China | 2989 | 58 | Inquiry |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | China | 21675 | 55 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29900 | 58 | Inquiry |
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