Mitoxantrone
- CAS No.
- 65271-80-9
- Chemical Name:
- Mitoxantrone
- Synonyms
- itoxantrone;mitoxanthrone;dihydroxyanthraquinone;Ralenova;NSC-27983;nsc279836;MITOXANTRONE;MITOXANTRONUM;MitoxantroneBase;PharmasubstanceEP4
- CBNumber:
- CB1246423
- Molecular Formula:
- C22H28N4O6
- Molecular Weight:
- 444.48
- MOL File:
- 65271-80-9.mol
- Modify Date:
- 2024/5/10 16:01:36
| Melting point | 170-1740C |
|---|---|
| Boiling point | 554.47°C (rough estimate) |
| Density | 1.3049 (rough estimate) |
| refractive index | 1.6500 (estimate) |
| storage temp. | Keep in dark place,Sealed in dry,2-8°C |
| solubility | DMSO (Slightly), Methanol (Sparingly), Water (Slightly) |
| pka | pKa 5.99 (Uncertain);8.13 (Uncertain) |
| form | Solid |
| color | Dark Blue to Black |
| InChI | InChI=1S/C22H28N4O6/c27-11-9-23-5-7-25-13-1-2-14(26-8-6-24-10-12-28)18-17(13)21(31)19-15(29)3-4-16(30)20(19)22(18)32/h1-4,23-30H,5-12H2 |
| InChIKey | KKZJGLLVHKMTCM-UHFFFAOYSA-N |
| SMILES | C1(O)=C2C(C(=O)C3=C(C2=O)C(NCCNCCO)=CC=C3NCCNCCO)=C(O)C=C1 |
| CAS DataBase Reference | 65271-80-9(CAS DataBase Reference) |
| IARC | 2B (Vol. 76) 2000 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS08,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H351-H411 | |||||||||
| Precautionary statements | P201-P202-P281-P308+P313-P405-P501 | |||||||||
| Hazard Codes | T,T+ | |||||||||
| Risk Statements | 46-61-26/27/28 | |||||||||
| Safety Statements | 53-36/37/39-45-22 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | CB5748500 | |||||||||
| HS Code | 2922.50.2500 | |||||||||
| NFPA 704 |
|
Mitoxantrone price More Price(2)
Mitoxantrone Chemical Properties,Uses,Production
Chemical Properties
Dark Blue Crystalline Solid
Uses
Mitoxantrone is a DNA intercalating drug. Mitoxantrone inhibits DNA synthesis. Mitoxantrone is used as an anti-cancer agent.
Indications
Mitoxantrone (Novantrone) is a synthetic anthraquinone
that is structurally and mechanistically related to the anthracyclines.
It intercalates with DNA and produces single-
strand DNA breakage. It is cross-resistant with doxorubicin
in multidrug-resistant cells and in patients who
have failed to respond to doxorubicin therapy.
Mitoxantrone is active against breast carcinomas,
leukemias, and lymphomas. Its antitumor efficacy in patients
with breast cancer is slightly lower than that of
doxorubicin. Its major toxicity is myelosuppression; mucositis
and diarrhea also may occur. Mitoxantrone produces
less nausea, alopecia, and cardiac toxicity than
does doxorubicin.
Mechanism of action
The mechanism of its action is not completely understood, although it is presumed, that mitoxantrone acts by binding with DNA, thus disturbing the twisting process of the chains. It is used intravenously for treating severe nonlymphatic leukemia, breast cancer, and so on. A synonym of this drug is novantrone.
Mitoxantrone Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 222)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Cosmas Research Lab Limited | 08069023904Ext 564 | Punjab, India | 2 | 58 | Inquiry |
| Jinan Good Medical Technology Co.,Ltd | +86-53155562571 +86-008613553167512 | China | 23 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29898 | 58 | Inquiry |
| BOC Sciences | +1-631-485-4226 | United States | 19553 | 58 | Inquiry |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | China | 23556 | 58 | Inquiry |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | China | 25247 | 58 | Inquiry |
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65271-80-9(Mitoxantrone)Related Search:
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Mitoxantrone2Hcl,MITOXANTRONE HCL USP,MITOXANTRONE HCL,MITOXANTRONE HYDROCHLORIDE SALT,MITOXANTRONE HYDROCHLORIDE,MITOXANTRONE DIHYDROCHLORIDE
Mitoxantrone HCL for Injection (Lyophilized Power)
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MITOXANTRONE
1,4-dihydroxy-5,8-bis(2-((2-hydroxyethyl)amino)ethylamino)-9,10-anthracenedi
1,4-dihydroxy-5,8-bis[2-(2-hydroxyethylamino)ethylamino]-anthracene-9,10-dione
Mitoxantrone (base and/or unspecified salts)
MITOXANTRONUM
1,4-Dihydroxy-5,8-bis[2-[(2-hydroxyethyl)amino]ethylamino]-9,10-anthraquinone
MitoxantroneBase
Mitoxantrone Hcl 70476-82-3 / Base
PharmasubstanceEP4
1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9,10-anthracenedione
NSC-27983
9,10-Anthracenedione, 1,4-dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-
1,4-dihydroxy-5,8-bis(2-((2-hydroxyethyl)amino)ethylamino)-9,10-anthrace nedimitoxantrone
MITOXANTRONUM AND THE INTERMEDIATES
Ralenova
Mitoxantrone
1,4-Dihydroxy-5,8-bis[2-(2-hydroxyethylamino)ethylamino]-anthracene-9,10-dione
5,8-bis((2-((2-hydroxyethyl)amino)ethyl)amino)-1,4-dihydroxy-anthraquinon
5,8-bis((2-((2-hydroxyethyl)amino)ethyl)amino)-1,4-dihydroxyanthraquinone
9,10-anthracenedione,1,4-dihydroxy-5,8-bis((2-((2-hydroxyethyl)amino)ethyl)a
nsc279836
Mitoxantrone Control
1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]anthraquinone
Mitoxantrone USP/EP/BP
Mitoxantrone (Base,Hcl)
Mitoxantrone (mitozantrone)
dihydroxyanthraquinone
itoxantrone
mitoxanthrone
65271-80-9
C22H28N4O6
Apoptosis and Cell Cycle
BioChemical
Cell Biology
Cell Signaling and Neuroscience
DNA Intercalators and Crosslinkers
DNA metabolism
Inhibitors
Anti-cancer&immunity
Pharmaceutical material and intermeidates
Intermediates & Fine Chemicals
Pharmaceuticals
APIs
API