N,O-BIS(TRIMETHYLSILYL)HYDROXYLAMINE
- CAS No.
- 22737-37-7
- Chemical Name:
- N,O-BIS(TRIMETHYLSILYL)HYDROXYLAMINE
- Synonyms
- AKOS MSC-0143;Bis(trimethylsilyl)hydroxylamine;N,O-BIS(TRIMETHYLSILYL)HYDROXYLAMINE;N,0-Bis(trimethylsilyl)hydroxylamine;O,N-Bis(trimethylsilyl)hydroxylamine;N,O-Bis-(trimethylsilyl)-hydroxylamin;(Trimethylsiloxy)(trimethylsilyl)amine;N,O-Bis(trimethylsilyl)hydroxylamine >N,O-BIS(TRIMETHYLSILYL)HYDROXYLAMINE, 97 %;[dimethyl-(trimethylsilyloxyamino)silyl]methane
- CBNumber:
- CB0779294
- Molecular Formula:
- C6H19NOSi2
- Molecular Weight:
- 177.39
- MOL File:
- 22737-37-7.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/6/8 17:06:37
| Boiling point | 78-80 °C100 mm Hg(lit.) |
|---|---|
| Density | 0.83 g/mL at 25 °C(lit.) |
| refractive index |
n |
| Flash point | 84 °F |
| storage temp. | 2-8°C |
| solubility | sol THF, ether, pentane, CH2Cl2. |
| pka | 5.94±0.70(Predicted) |
| form | clear liquid |
| color | Colorless to Almost colorless |
| Specific Gravity | 0.83 |
| Hydrolytic Sensitivity | 7: reacts slowly with moisture/water |
| BRN | 1920452 |
| CAS DataBase Reference | 22737-37-7(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H226-H314 | |||||||||
| Precautionary statements | P210-P233-P240-P280-P303+P361+P353-P305+P351+P338 | |||||||||
| Hazard Codes | Xi,C | |||||||||
| Risk Statements | 10-36/37/38-34 | |||||||||
| Safety Statements | 26-36-45-36/37/39 | |||||||||
| RIDADR | UN 1993 3/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 10-21 | |||||||||
| TSCA | No | |||||||||
| HazardClass | 3.2 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29319019 | |||||||||
| NFPA 704 |
|
N,O-BIS(TRIMETHYLSILYL)HYDROXYLAMINE price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 235105 | N,O-Bis(trimethylsilyl)hydroxylamine 97% | 22737-37-7 | 1G | ₹2814.5 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 235105 | N,O-Bis(trimethylsilyl)hydroxylamine 97% | 22737-37-7 | 10G | ₹19766.45 | 2022-06-14 | Buy |
| TCI Chemicals (India) | B1825 | N,O-Bis(trimethylsilyl)hydroxylamine min. 95.0 % | 22737-37-7 | 5G | ₹14200 | 2022-05-26 | Buy |
N,O-BIS(TRIMETHYLSILYL)HYDROXYLAMINE Chemical Properties,Uses,Production
Chemical Properties
Clear colorless liquid
Physical properties
bp 137–139°C, 78–80°C/100 mmHg; d 0.830 g cm?3; flash point 28°C.
Uses
N,O-Bis(trimethylsilyl)hydroxylamine
is a protected, lipophilic form of hydroxylamine. It reacts
with a variety of electrophiles predominantly by attack on the nitrogen
nucleophilic center. Reaction with acid chlorides (1 equiv)
in the presence of triethylamine gives N,O-bis(trimethylsilyl)-
hydroxamic acids by N-acylation.A related reagent, tris(trimethylsilyl)
hydroxylamine, gives the same product in high yields,
also by N-acylation.Hydrolysis gives the free hydroxamic
acids, whereas thermal fragmentation affords isocyanates (eq 1).
Preparation
N,O-Bis(trimethylsilyl)hydroxylamine can be prepared in 69% yield by treating dry hydroxylamine with equiv chlorotrimethylsilane and equiv triethylamine.A safer preparation, which avoids the use of the explosive solid, hydroxylamine, uses the reaction of hydroxylamine hydrochloride with excess hexamethyldisilazane (71–75% yield).Alternatively, neutralization of hydroxylamine hydrochloride with ethylenediamine followed by addition of chlorotrimethylsilane can be used.
General Description
N,O-Bis(trimethylsilyl)hydroxylamine on reaction with 9-chloro-9-borafluorene yields 10-trimethylsilyloxy-9-aza-10-boraphenanthrene. It reacts with free phenolic steroids during the analysis of conjugated estrogen tablets and injectable formulations by GLC.
N,O-BIS(TRIMETHYLSILYL)HYDROXYLAMINE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Alfa Aesar | 1 800 209 7001 | Maharashtra, India | 6913 | 58 | Inquiry |
| Clearsynth Labs | 91-22-45045900 | Maharashtra, India | 3889 | 58 | Inquiry |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | China | 18656 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29820 | 58 | Inquiry |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | China | 34571 | 58 | Inquiry |
| Alfa Chemistry | United States | 2344 | 58 | Inquiry | |
| Aston Chemical | 13000000000 | United States | 1634 | 58 | Inquiry |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | China | 52861 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| A.J Chemicals | 58 |
| TCI Chemicals (India) Pvt. Ltd. | 58 |
| Alfa Aesar | 58 |
| Clearsynth Labs | 58 |
| Shanghai Daken Advanced Materials Co.,Ltd | 58 |
| career henan chemical co | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 58 |
| Alfa Chemistry | 58 |
| Aston Chemical | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | 58 |