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ChemicalBook > Product Catalog >Biochemical Engineering >Amino Acids and Derivatives >Lysine derivatives >Copper Peptide

Copper Peptide

Copper Peptide Structure
CAS No.
49557-75-7
Chemical Name:
Copper Peptide
Synonyms
GHK;Ahk-cu;Glycyl-L-Histidyl-L-Lysine;GHK Cu Copper Peptide;Tripeptide-1 Copper;Copper Peptide AHK-Cu;Cu-GHK;Copper peptides;Copper Peptide powder (GHK-cu);GHK2-CU
CBNumber:
CB0875341
Molecular Formula:
C14H24N6O4
Molecular Weight:
340.38
MOL File:
49557-75-7.mol
Modify Date:
2024/8/21 22:41:43
Request For Quotation

Copper Peptide Properties

Melting point >144°C (dec.)
Boiling point 831.0±65.0 °C(Predicted)
Density 1.324
storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
solubility Aqueous Acid (Slightly), DMSO (Slightly)
form Solid
pka 3.11±0.10(Predicted)
color Off-White
Sequence Copper gly-his-lys
Stability Hygroscopic
InChIKey MVORZMQFXBLMHM-QWRGUYRKSA-N
SMILES C(O)(=O)[C@H](CCCCN)NC(=O)[C@H](CC1N=CNC=1)NC(=O)CN

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H317-H319
Precautionary statements  P280-P305+P351+P338

Copper Peptide Chemical Properties,Uses,Production

Description

Copper peptide GHK-Cu is a naturally occurring copper complex of the tripeptide glycyl-L-histidyl-L-lysine. The tripeptide has strong affinity for copper(II) and was first isolated from human plasma. It can be found also in saliva and urine.

Uses

anti-wrikle

Definition

ChEBI: A tripeptide composed of glycine, L-histidine and L-lysine residues joined in sequence.

Biological Functions

When applied topically, copper peptide works as an antioxidant, promote collagen and elastin production, and soften the appearance of fine lines and wrinkles.

Pharmaceutical Applications

Glycyl-l-histidyl-l-lysine (GHK) is a tripeptide known for its high binding affinity to Cu2+ and its complex role in wound healing. The GHK–Cu(II) complex was isolated from human plasma in the 1970s and it was shown to be an activator for wound healing. GHK–Cu(II) has two main functions: as an anti-inflammatory agent to protect the tissue from oxidative damage after the injury, and as an activator for wound healing itself as it activates the tissue remodelling.
The structure of GHK is very similar to that of common drugs used to treat ulcers.
After the initial stages of wound healing are activated, such as blood coagulation and neutrophil invasion, a second stage of wound healing begins, which includes the population of GHK at the wound, which has a high affinity to Cu2+. Mast cells, which are located in the skin, secrete GHK, which accumulates Cu2+ and forms the copper complex GHK–Cu(II) and therefore increases the metal–tripeptide concentration at the wound. First, GHK–Cu(II) has an anti-inflammatory effect by protecting the tissue from oxidative damage and by suppressing local inflammatory signals (i.e. cytokine interleukin-1 (IL-1)). Second, GHK–Cu(II) is released into the blood stream and encourages the production of wound macrophages that support the wound repair by removing the damaged tissue and secreting a family of several growth factor proteins. GHK–Cu(II) also hinders fibroblast production of TGF-β-1 and therefore suppresses the scar development. The GHK–Cu(II) complex also stimulates the growth of blood vessels, neurons and elastin, and, in general, supports most processes of wound healing.

Side effects

While Copper Peptide Serum is generally safe to use, you should be aware of potential side effects that may occur. Although rare, some individuals may experience skin irritation or redness after applying the serum. This can be due to sensitivity to the ingredients or an allergic reaction. Another potential side effect of Copper Peptide Serum is increased sensitivity to sunlight. The serum can make your skin more prone to sunburn.

Copper Peptide Preparation Products And Raw materials

Raw materials

Fmoc-His(Trt)-OH Fmoc-Lys(Boc)-OH Fmoc-Gly-OH

Preparation Products

Copper Peptide Suppliers

Global( 443)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
Shanghai Likang New Materials Co., Limited +86-16631818819 +86-17736933208 China 9311 58 Inquiry
Xi'an Kono chem co., Ltd., 029-86107037 13289246953 China 2995 58 Inquiry
Changzhou Xuanming Pharmaceutical Technology Co., Ltd. +8615995072465 China 906 58 Inquiry
XI'AN TIANGUANGYUAN BIOTECH CO., LTD. +86-029-86333380 18829239519 China 903 58 Inquiry
ZhenYiBio Technology Inc +8615309206328 China 298 58 Inquiry
Zhuzhou New Peptides Tech Co.,Ltd. +86-18073326374 +86-18073326374 China 145 58 Inquiry
Wuhan Haorong Biotechnology Co.,ltd +86-18565342920; +8618565342920 China 289 58 Inquiry
Sigma Audley +86-15937194204 +86-18126314766 China 491 58 Inquiry
Supplier Advantage
A.J Chemicals 58
CLEARSYNTH LABS LTD. 58
Shanghai Likang New Materials Co., Limited 58
Xi'an Kono chem co., Ltd., 58
Changzhou Xuanming Pharmaceutical Technology Co., Ltd. 58
XI'AN TIANGUANGYUAN BIOTECH CO., LTD. 58
ZhenYiBio Technology Inc 58
Zhuzhou New Peptides Tech Co.,Ltd. 58
Wuhan Haorong Biotechnology Co.,ltd 58
Sigma Audley 58

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